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Seroepidemiology and molecular characterization of hepatitis E virus in Jilin, China.
Infection. 2008 Mar; 36(2):140-6.I

Abstract

BACKGROUND

In order to develop region-specific diagnostic assays and prevent hepatitis E virus (HEV), it is essential to understand epidemiology and genotypic variation within different populations. However, the epidemiological data of HEV infections in Jilin is shortage.

METHODS

The seroepidemiological study was conducted by enzyme-linked immunosorbent assay, and the conserved genomic sequences of open reading frame 2 (348 bp) was detected using reverse transcription-PCR.

RESULTS

Overall, 1,289 serum samples were positive to HEV-specific immunoglobulin G (IgG), and 180 serum samples were positive to HEV-specific immunoglobulin M (IgM). The seroprevalence of HEV-specific IgG was 26.3%, 27.9%, 25.3%, 32.7% in 2003, 2004, 2005, 2006, respectively. Acute HEV infection mainly occurred in male, people aged from 20 to 69 were more susceptible to infection, and cases with IgM anti-HEV reaction mainly occurred from July to November. HEV RNA was detectable in the serum samples or stool suspension of 15 patients with HEV-specific IgM, and all of these belonged to genotype IV.

CONCLUSIONS

Our results indicate that HEV is widely spread in Jilin and confined to genotype IV.

Authors+Show Affiliations

Genetic Engineering Laboratory, Academy of Military Medical Sciences, 1068 Qinglong Road, Changchun, 130062, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18330507

Citation

Zhu, G, et al. "Seroepidemiology and Molecular Characterization of Hepatitis E Virus in Jilin, China." Infection, vol. 36, no. 2, 2008, pp. 140-6.
Zhu G, Qu Y, Jin N, et al. Seroepidemiology and molecular characterization of hepatitis E virus in Jilin, China. Infection. 2008;36(2):140-6.
Zhu, G., Qu, Y., Jin, N., Sun, Z., Liu, T., Lee, H., Tian, M., & Wang, T. (2008). Seroepidemiology and molecular characterization of hepatitis E virus in Jilin, China. Infection, 36(2), 140-6. https://doi.org/10.1007/s15010-007-7130-8
Zhu G, et al. Seroepidemiology and Molecular Characterization of Hepatitis E Virus in Jilin, China. Infection. 2008;36(2):140-6. PubMed PMID: 18330507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seroepidemiology and molecular characterization of hepatitis E virus in Jilin, China. AU - Zhu,G, AU - Qu,Y, AU - Jin,N, AU - Sun,Z, AU - Liu,T, AU - Lee,H, AU - Tian,M, AU - Wang,T, Y1 - 2008/03/12/ PY - 2007/03/16/received PY - 2007/08/16/accepted PY - 2008/3/12/pubmed PY - 2008/11/13/medline PY - 2008/3/12/entrez SP - 140 EP - 6 JF - Infection JO - Infection VL - 36 IS - 2 N2 - BACKGROUND: In order to develop region-specific diagnostic assays and prevent hepatitis E virus (HEV), it is essential to understand epidemiology and genotypic variation within different populations. However, the epidemiological data of HEV infections in Jilin is shortage. METHODS: The seroepidemiological study was conducted by enzyme-linked immunosorbent assay, and the conserved genomic sequences of open reading frame 2 (348 bp) was detected using reverse transcription-PCR. RESULTS: Overall, 1,289 serum samples were positive to HEV-specific immunoglobulin G (IgG), and 180 serum samples were positive to HEV-specific immunoglobulin M (IgM). The seroprevalence of HEV-specific IgG was 26.3%, 27.9%, 25.3%, 32.7% in 2003, 2004, 2005, 2006, respectively. Acute HEV infection mainly occurred in male, people aged from 20 to 69 were more susceptible to infection, and cases with IgM anti-HEV reaction mainly occurred from July to November. HEV RNA was detectable in the serum samples or stool suspension of 15 patients with HEV-specific IgM, and all of these belonged to genotype IV. CONCLUSIONS: Our results indicate that HEV is widely spread in Jilin and confined to genotype IV. SN - 0300-8126 UR - https://www.unboundmedicine.com/medline/citation/18330507/Seroepidemiology_and_molecular_characterization_of_hepatitis_E_virus_in_Jilin_China_ L2 - https://doi.org/10.1007/s15010-007-7130-8 DB - PRIME DP - Unbound Medicine ER -