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Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis.

Abstract

While dementia affects 6-10% of persons 65 years or older, industrialized countries have witnessed an alarming rise in obesity. However, obesity's influence on dementia remains poorly understood. We conducted a systematic review and meta-analysis. PUBMED search (1995-2007) resulted in 10 relevant prospective cohort studies of older adults (40-80 years at baseline) with end points being dementia and predictors including adiposity measures, such as body mass index (BMI) and waist circumference (WC). There was a significant U-shaped association between BMI and dementia (P = 0.034), with dementia risk increased for obesity and underweight. Pooled odds ratios (OR) and 95% confidence intervals (CI) for underweight, overweight and obesity compared with normal weight in relation to incident dementia were: 1.36 (1.07, 1.73), 0.88 (0.60, 1.27) and 1.42 (0.93, 2.18) respectively. Pooled ORs and 95% CI for obesity and incident Alzheimer's disease (AD) and vascular dementia were 1.80 (1.00, 3.29) vs. 1.73 (0.47, 6.31) and were stronger in studies with long follow-up (>10 years) and young baseline age (<60 years). Weight gain and high WC or skin-fold thickness increased risks of dementia in all included studies. The meta-analysis shows a moderate association between obesity and the risks for dementia and AD. Future studies are needed to understand optimal weight and biological mechanisms.

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  • Authors+Show Affiliations

    ,

    Center for Human Nutrition, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

    ,

    Source

    MeSH

    Adipose Tissue
    Adult
    Aged
    Aged, 80 and over
    Alzheimer Disease
    Body Mass Index
    Cohort Studies
    Comorbidity
    Dementia
    Humans
    Incidence
    Middle Aged
    Obesity
    Odds Ratio
    Prospective Studies
    Risk Factors
    Skinfold Thickness

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Systematic Review

    Language

    eng

    PubMed ID

    18331422

    Citation

    Beydoun, M A., et al. "Obesity and Central Obesity as Risk Factors for Incident Dementia and Its Subtypes: a Systematic Review and Meta-analysis." Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, vol. 9, no. 3, 2008, pp. 204-18.
    Beydoun MA, Beydoun HA, Wang Y. Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obes Rev. 2008;9(3):204-18.
    Beydoun, M. A., Beydoun, H. A., & Wang, Y. (2008). Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, 9(3), pp. 204-18. doi:10.1111/j.1467-789X.2008.00473.x.
    Beydoun MA, Beydoun HA, Wang Y. Obesity and Central Obesity as Risk Factors for Incident Dementia and Its Subtypes: a Systematic Review and Meta-analysis. Obes Rev. 2008;9(3):204-18. PubMed PMID: 18331422.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. AU - Beydoun,M A, AU - Beydoun,H A, AU - Wang,Y, Y1 - 2008/03/06/ PY - 2008/3/12/pubmed PY - 2008/6/6/medline PY - 2008/3/12/entrez SP - 204 EP - 18 JF - Obesity reviews : an official journal of the International Association for the Study of Obesity JO - Obes Rev VL - 9 IS - 3 N2 - While dementia affects 6-10% of persons 65 years or older, industrialized countries have witnessed an alarming rise in obesity. However, obesity's influence on dementia remains poorly understood. We conducted a systematic review and meta-analysis. PUBMED search (1995-2007) resulted in 10 relevant prospective cohort studies of older adults (40-80 years at baseline) with end points being dementia and predictors including adiposity measures, such as body mass index (BMI) and waist circumference (WC). There was a significant U-shaped association between BMI and dementia (P = 0.034), with dementia risk increased for obesity and underweight. Pooled odds ratios (OR) and 95% confidence intervals (CI) for underweight, overweight and obesity compared with normal weight in relation to incident dementia were: 1.36 (1.07, 1.73), 0.88 (0.60, 1.27) and 1.42 (0.93, 2.18) respectively. Pooled ORs and 95% CI for obesity and incident Alzheimer's disease (AD) and vascular dementia were 1.80 (1.00, 3.29) vs. 1.73 (0.47, 6.31) and were stronger in studies with long follow-up (>10 years) and young baseline age (<60 years). Weight gain and high WC or skin-fold thickness increased risks of dementia in all included studies. The meta-analysis shows a moderate association between obesity and the risks for dementia and AD. Future studies are needed to understand optimal weight and biological mechanisms. SN - 1467-789X UR - https://www.unboundmedicine.com/medline/citation/18331422/Obesity_and_central_obesity_as_risk_factors_for_incident_dementia_and_its_subtypes:_a_systematic_review_and_meta_analysis_ L2 - https://doi.org/10.1111/j.1467-789X.2008.00473.x DB - PRIME DP - Unbound Medicine ER -