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No apparent local effect of insulin on microdialysis continuous glucose- monitoring measurements.
Diabetes Care. 2008 Jun; 31(6):1120-2.DC

Abstract

OBJECTIVE

Data investigating the possible disturbing influence of insulin in the vicinity of continuous glucose monitoring (CGM) is lacking. We investigated the hypothesis that high local insulin concentrations would interfere with sensor readings.

RESEARCH DESIGN AND METHODS

Two microdialysis sensors were inserted in the periumbilical region of 10 continuous subcutaneous insulin infusion (CSII)-treated type 1 patients. A test sensor was inserted as close as possible to the insulin catheter and compared with a control sensor. Glucose peak and nadir were induced. Horizontal and vertical shifts were assessed using curve fitting, and mean absolute difference (MAD) between paired blood and sensor values were calculated.

RESULTS

Curve fitting showed no significant differences between the two sensors. MAD +/- SD was 8.50 +/- 3.47% for the test sensor and 9.21 +/- 3.17% for the control sensor, P = 0.72.

CONCLUSIONS

Microdialysis CGM can be accurately performed in the proximity of CSII systems.

Authors+Show Affiliations

Academic Medical Center, Amsterdam, the Netherlands. j.hermanides@amc.uva.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18332157

Citation

Hermanides, Jeroen, et al. "No Apparent Local Effect of Insulin On Microdialysis Continuous Glucose- Monitoring Measurements." Diabetes Care, vol. 31, no. 6, 2008, pp. 1120-2.
Hermanides J, Wentholt IM, Hart AA, et al. No apparent local effect of insulin on microdialysis continuous glucose- monitoring measurements. Diabetes Care. 2008;31(6):1120-2.
Hermanides, J., Wentholt, I. M., Hart, A. A., Hoekstra, J. B., & DeVries, J. H. (2008). No apparent local effect of insulin on microdialysis continuous glucose- monitoring measurements. Diabetes Care, 31(6), 1120-2. https://doi.org/10.2337/dc08-0145
Hermanides J, et al. No Apparent Local Effect of Insulin On Microdialysis Continuous Glucose- Monitoring Measurements. Diabetes Care. 2008;31(6):1120-2. PubMed PMID: 18332157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No apparent local effect of insulin on microdialysis continuous glucose- monitoring measurements. AU - Hermanides,Jeroen, AU - Wentholt,Iris M, AU - Hart,Augustinus A, AU - Hoekstra,Joost B, AU - DeVries,J Hans, Y1 - 2008/03/10/ PY - 2008/3/12/pubmed PY - 2008/8/7/medline PY - 2008/3/12/entrez SP - 1120 EP - 2 JF - Diabetes care JO - Diabetes Care VL - 31 IS - 6 N2 - OBJECTIVE: Data investigating the possible disturbing influence of insulin in the vicinity of continuous glucose monitoring (CGM) is lacking. We investigated the hypothesis that high local insulin concentrations would interfere with sensor readings. RESEARCH DESIGN AND METHODS: Two microdialysis sensors were inserted in the periumbilical region of 10 continuous subcutaneous insulin infusion (CSII)-treated type 1 patients. A test sensor was inserted as close as possible to the insulin catheter and compared with a control sensor. Glucose peak and nadir were induced. Horizontal and vertical shifts were assessed using curve fitting, and mean absolute difference (MAD) between paired blood and sensor values were calculated. RESULTS: Curve fitting showed no significant differences between the two sensors. MAD +/- SD was 8.50 +/- 3.47% for the test sensor and 9.21 +/- 3.17% for the control sensor, P = 0.72. CONCLUSIONS: Microdialysis CGM can be accurately performed in the proximity of CSII systems. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/18332157/No_apparent_local_effect_of_insulin_on_microdialysis_continuous_glucose__monitoring_measurements_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=18332157 DB - PRIME DP - Unbound Medicine ER -