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Open-angle glaucoma and mortality: The Barbados Eye Studies.
Arch Ophthalmol 2008; 126(3):365-70AO

Abstract

OBJECTIVE

To evaluate the relationship between open-angle glaucoma (OAG) and mortality in a black population at 9-years' follow-up.

DESIGN

Population-based cohort study of 4092 black participants (aged 40-84 years at baseline) in the Barbados Eye Studies. Open-angle glaucoma was defined by visual field defects and optic disc damage, based on standardized examinations and photograph gradings. Ocular hypertension was defined by an intraocular pressure greater than 21 mm Hg or treatment, without OAG damage. Mortality was ascertained from death certificates. Cox proportional hazards regression analyses determined associations with mortality.

RESULTS

After 9 years, 764 (19%) participants were deceased. Mortality was unrelated to overall OAG at baseline (n = 300) after adjustment for confounders. However, cardiovascular mortality tended to increase in persons with previously diagnosed/treated OAG (n = 141; relative risk [RR], 1.38, P = .07) and was significantly higher with treatment involving timolol maleate (RR, 1.91, P = .04). Cardiovascular deaths also tended to increase in persons with ocular hypertension at baseline (n = 498; RR, 1.28, P = .06).

CONCLUSIONS

In this black population, cardiovascular mortality tended to increase in persons with previously diagnosed/treated OAG and ocular hypertension. The excess mortality associated with timolol maleate treatment of OAG, also found in a white population, warrants further investigation.

Authors+Show Affiliations

Department of Preventive Medicine, Stony Brook University, Stony Brook, NY 11794-8036, USA. swu@notes.cc.sunysb.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18332317

Citation

Wu, Suh-Yuh, et al. "Open-angle Glaucoma and Mortality: the Barbados Eye Studies." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 126, no. 3, 2008, pp. 365-70.
Wu SY, Nemesure B, Hennis A, et al. Open-angle glaucoma and mortality: The Barbados Eye Studies. Arch Ophthalmol. 2008;126(3):365-70.
Wu, S. Y., Nemesure, B., Hennis, A., Schachat, A. P., Hyman, L., & Leske, M. C. (2008). Open-angle glaucoma and mortality: The Barbados Eye Studies. Archives of Ophthalmology (Chicago, Ill. : 1960), 126(3), pp. 365-70. doi:10.1001/archophthalmol.2007.77.
Wu SY, et al. Open-angle Glaucoma and Mortality: the Barbados Eye Studies. Arch Ophthalmol. 2008;126(3):365-70. PubMed PMID: 18332317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Open-angle glaucoma and mortality: The Barbados Eye Studies. AU - Wu,Suh-Yuh, AU - Nemesure,Barbara, AU - Hennis,Anselm, AU - Schachat,Andrew P, AU - Hyman,Leslie, AU - Leske,M Cristina, AU - ,, PY - 2008/3/12/pubmed PY - 2008/4/25/medline PY - 2008/3/12/entrez SP - 365 EP - 70 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 126 IS - 3 N2 - OBJECTIVE: To evaluate the relationship between open-angle glaucoma (OAG) and mortality in a black population at 9-years' follow-up. DESIGN: Population-based cohort study of 4092 black participants (aged 40-84 years at baseline) in the Barbados Eye Studies. Open-angle glaucoma was defined by visual field defects and optic disc damage, based on standardized examinations and photograph gradings. Ocular hypertension was defined by an intraocular pressure greater than 21 mm Hg or treatment, without OAG damage. Mortality was ascertained from death certificates. Cox proportional hazards regression analyses determined associations with mortality. RESULTS: After 9 years, 764 (19%) participants were deceased. Mortality was unrelated to overall OAG at baseline (n = 300) after adjustment for confounders. However, cardiovascular mortality tended to increase in persons with previously diagnosed/treated OAG (n = 141; relative risk [RR], 1.38, P = .07) and was significantly higher with treatment involving timolol maleate (RR, 1.91, P = .04). Cardiovascular deaths also tended to increase in persons with ocular hypertension at baseline (n = 498; RR, 1.28, P = .06). CONCLUSIONS: In this black population, cardiovascular mortality tended to increase in persons with previously diagnosed/treated OAG and ocular hypertension. The excess mortality associated with timolol maleate treatment of OAG, also found in a white population, warrants further investigation. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/18332317/Open_angle_glaucoma_and_mortality:_The_Barbados_Eye_Studies_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/archophthalmol.2007.77 DB - PRIME DP - Unbound Medicine ER -