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Necrotizing periodontal diseases in HIV-seropositive subjects: pathogenic mechanisms.
J Int Acad Periodontol. 2008 Jan; 10(1):10-5.JI

Abstract

Necrotizing gingivitis (NG) is a well-known periodontal condition characterized by marginal gingival necrosis, bleeding and pain. Necrotizing periodontitis is an extension of NG into the periodontal attachment apparatus, and the two stages are referred to collectively as necrotizing periodontal diseases (NPD). Necrotizing periodontal diseases in HIV-seropositive subjects are similar with regard to the spectrum of periodontopathic bacteria, the clinical manifestations, the natural course and the response to treatment when compared to NPD in HIV-seronegative subjects. However, in the former group, there is an increase in the prevalence of candidal species and herpesviruses in the subgingival plaque and gingival biopsy specimens. In the periodontal tissues, spirochaetes, activated herpesviruses, Candida species and HIV have the capability of deregulating host innate and adaptive immune responses and of stimulating host inflammatory reactions, and may therefore explain the greater prevalence of NPD in HIV-seropositive subjects compared to immunocompetent subjects.

Authors+Show Affiliations

Feller L
Department of Periodontology and Oral Medicine, Faculty of Dentistry, University of Limpopo, Medunsa Campus, South Africa. lfeller@medunsa.ac.za
Lemmer J
No affiliation info available

MeSH

Anti-Infective AgentsCandida albicansChlorhexidineCytokinesDental ScalingGingivitis, Necrotizing UlcerativeHIV SeropositivityHerpesviridaeHumansImmunocompromised HostMetronidazolePeriodontitisSpirochaetalesT-Lymphocytes

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18333595

Citation

Feller, Liviu, and Johan Lemmer. "Necrotizing Periodontal Diseases in HIV-seropositive Subjects: Pathogenic Mechanisms." Journal of the International Academy of Periodontology, vol. 10, no. 1, 2008, pp. 10-5.
Feller L, Lemmer J. Necrotizing periodontal diseases in HIV-seropositive subjects: pathogenic mechanisms. J Int Acad Periodontol. 2008;10(1):10-5.
Feller, L., & Lemmer, J. (2008). Necrotizing periodontal diseases in HIV-seropositive subjects: pathogenic mechanisms. Journal of the International Academy of Periodontology, 10(1), 10-5.
Feller L, Lemmer J. Necrotizing Periodontal Diseases in HIV-seropositive Subjects: Pathogenic Mechanisms. J Int Acad Periodontol. 2008;10(1):10-5. PubMed PMID: 18333595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Necrotizing periodontal diseases in HIV-seropositive subjects: pathogenic mechanisms. AU - Feller,Liviu, AU - Lemmer,Johan, PY - 2008/3/13/pubmed PY - 2008/4/29/medline PY - 2008/3/13/entrez SP - 10 EP - 5 JF - Journal of the International Academy of Periodontology JO - J Int Acad Periodontol VL - 10 IS - 1 N2 - Necrotizing gingivitis (NG) is a well-known periodontal condition characterized by marginal gingival necrosis, bleeding and pain. Necrotizing periodontitis is an extension of NG into the periodontal attachment apparatus, and the two stages are referred to collectively as necrotizing periodontal diseases (NPD). Necrotizing periodontal diseases in HIV-seropositive subjects are similar with regard to the spectrum of periodontopathic bacteria, the clinical manifestations, the natural course and the response to treatment when compared to NPD in HIV-seronegative subjects. However, in the former group, there is an increase in the prevalence of candidal species and herpesviruses in the subgingival plaque and gingival biopsy specimens. In the periodontal tissues, spirochaetes, activated herpesviruses, Candida species and HIV have the capability of deregulating host innate and adaptive immune responses and of stimulating host inflammatory reactions, and may therefore explain the greater prevalence of NPD in HIV-seropositive subjects compared to immunocompetent subjects. SN - 1466-2094 UR - https://www.unboundmedicine.com/medline/citation/18333595/Necrotizing_periodontal_diseases_in_HIV_seropositive_subjects:_pathogenic_mechanisms_ DB - PRIME DP - Unbound Medicine ER -