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Cannabinoid concentrations in spot serum samples 24-48 hours after discontinuation of cannabis smoking.
J Anal Toxicol. 2008 Mar; 32(2):160-4.JA

Abstract

A blood concentration of tetrahydrocannabinol (THC) in the low nanograms-per-milliliter range is often claimed to result from drug use more than 24-48 h previously. The present investigation determined concentrations of cannabinoids in blood collected at least 24 h from smoking in an in-patient setting. During sampling, distinctive effects due to drug use could not be observed. The randomly collected samples from heavy (n = 16, > 1 joint/day), moderate (n = 15, < or = 1 joint/day), and light (n = 6, < 1 joint/week) users of cannabis were analyzed for THC, 11-hydroxy-THC (OH-THC), and free 11-nor-9-carboxy-THC (THCCOOH) by gas chromatography-mass spectrometry as well as for glucuronidated THCCOOH by liquid chromatography-tandem mass spectrometry. THC was detectable in 9, 6, and 1 samples from heavy, moderate, and light users, respectively. Although cannabinoid concentrations were overlapping between groups, there was a trend towards higher concentrations of both conjugated and free THCCOOH in regular users compared to occasional users. The present findings appear to indicate that low levels of THC, or of THC along with OH-THC, may not unequivocally prove a very recent use of cannabis.

Authors+Show Affiliations

Institute of Legal Medicine and Traffic Medicine, University, Heidelberg, Germany. gisela.skopp@med.uni-heidelberg.deNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18334100

Citation

Skopp, Gisela, and Lucia Pötsch. "Cannabinoid Concentrations in Spot Serum Samples 24-48 Hours After Discontinuation of Cannabis Smoking." Journal of Analytical Toxicology, vol. 32, no. 2, 2008, pp. 160-4.
Skopp G, Pötsch L. Cannabinoid concentrations in spot serum samples 24-48 hours after discontinuation of cannabis smoking. J Anal Toxicol. 2008;32(2):160-4.
Skopp, G., & Pötsch, L. (2008). Cannabinoid concentrations in spot serum samples 24-48 hours after discontinuation of cannabis smoking. Journal of Analytical Toxicology, 32(2), 160-4.
Skopp G, Pötsch L. Cannabinoid Concentrations in Spot Serum Samples 24-48 Hours After Discontinuation of Cannabis Smoking. J Anal Toxicol. 2008;32(2):160-4. PubMed PMID: 18334100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabinoid concentrations in spot serum samples 24-48 hours after discontinuation of cannabis smoking. AU - Skopp,Gisela, AU - Pötsch,Lucia, PY - 2008/3/13/pubmed PY - 2008/4/23/medline PY - 2008/3/13/entrez SP - 160 EP - 4 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 32 IS - 2 N2 - A blood concentration of tetrahydrocannabinol (THC) in the low nanograms-per-milliliter range is often claimed to result from drug use more than 24-48 h previously. The present investigation determined concentrations of cannabinoids in blood collected at least 24 h from smoking in an in-patient setting. During sampling, distinctive effects due to drug use could not be observed. The randomly collected samples from heavy (n = 16, > 1 joint/day), moderate (n = 15, < or = 1 joint/day), and light (n = 6, < 1 joint/week) users of cannabis were analyzed for THC, 11-hydroxy-THC (OH-THC), and free 11-nor-9-carboxy-THC (THCCOOH) by gas chromatography-mass spectrometry as well as for glucuronidated THCCOOH by liquid chromatography-tandem mass spectrometry. THC was detectable in 9, 6, and 1 samples from heavy, moderate, and light users, respectively. Although cannabinoid concentrations were overlapping between groups, there was a trend towards higher concentrations of both conjugated and free THCCOOH in regular users compared to occasional users. The present findings appear to indicate that low levels of THC, or of THC along with OH-THC, may not unequivocally prove a very recent use of cannabis. SN - 0146-4760 UR - https://www.unboundmedicine.com/medline/citation/18334100/Cannabinoid_concentrations_in_spot_serum_samples_24_48_hours_after_discontinuation_of_cannabis_smoking_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/32.2.160 DB - PRIME DP - Unbound Medicine ER -