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An improved PID switching control strategy for type 1 diabetes.
IEEE Trans Biomed Eng. 2008 Mar; 55(3):857-65.IT

Abstract

In order for an "artificial pancreas" to become a reality for ambulatory use, a practical closed-loop control strategy must be developed and validated. In this paper, an improved PID control strategy for blood glucose control is proposed and critically evaluated in silico using a physiologic model of Hovorka et al. [1]. The key features of the proposed control strategy are: 1) a switching strategy for initiating PID control after a meal and insulin bolus; 2) a novel time-varying setpoint trajectory; 3) noise and derivative filters to reduce sensitivity to sensor noise; and 4) a practical controller tuning strategy. Simulation results demonstrate that proposed control strategy compares favorably to alternatives for realistic conditions that include meal challenges, incorrect carbohydrate meal estimates, changes in insulin sensitivity, and measurement noise.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Marchetti G
Dipartimento di Principi e Impianti di Ingegneria Chimica, Università di Padova, 35131 Padova, Italy.
Barolo M
No affiliation info available
Jovanovic L
No affiliation info available
Zisser H
No affiliation info available
Seborg DE
No affiliation info available

MeSH

AlgorithmsBlood GlucoseDiabetes Mellitus, Type 1Drug MonitoringDrug Therapy, Computer-AssistedFeedbackHumansInsulinReproducibility of ResultsSensitivity and Specificity

Pub Type(s)

Evaluation Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18334377

Citation

Marchetti, Gianni, et al. "An Improved PID Switching Control Strategy for Type 1 Diabetes." IEEE Transactions On Bio-medical Engineering, vol. 55, no. 3, 2008, pp. 857-65.
Marchetti G, Barolo M, Jovanovic L, et al. An improved PID switching control strategy for type 1 diabetes. IEEE Trans Biomed Eng. 2008;55(3):857-65.
Marchetti, G., Barolo, M., Jovanovic, L., Zisser, H., & Seborg, D. E. (2008). An improved PID switching control strategy for type 1 diabetes. IEEE Transactions On Bio-medical Engineering, 55(3), 857-65. https://doi.org/10.1109/TBME.2008.915665
Marchetti G, et al. An Improved PID Switching Control Strategy for Type 1 Diabetes. IEEE Trans Biomed Eng. 2008;55(3):857-65. PubMed PMID: 18334377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An improved PID switching control strategy for type 1 diabetes. AU - Marchetti,Gianni, AU - Barolo,Massimiliano, AU - Jovanovic,Lois, AU - Zisser,Howard, AU - Seborg,Dale E, PY - 2008/3/13/pubmed PY - 2008/4/16/medline PY - 2008/3/13/entrez SP - 857 EP - 65 JF - IEEE transactions on bio-medical engineering JO - IEEE Trans Biomed Eng VL - 55 IS - 3 N2 - In order for an "artificial pancreas" to become a reality for ambulatory use, a practical closed-loop control strategy must be developed and validated. In this paper, an improved PID control strategy for blood glucose control is proposed and critically evaluated in silico using a physiologic model of Hovorka et al. [1]. The key features of the proposed control strategy are: 1) a switching strategy for initiating PID control after a meal and insulin bolus; 2) a novel time-varying setpoint trajectory; 3) noise and derivative filters to reduce sensitivity to sensor noise; and 4) a practical controller tuning strategy. Simulation results demonstrate that proposed control strategy compares favorably to alternatives for realistic conditions that include meal challenges, incorrect carbohydrate meal estimates, changes in insulin sensitivity, and measurement noise. SN - 0018-9294 UR - https://www.unboundmedicine.com/medline/citation/18334377/An_improved_PID_switching_control_strategy_for_type_1_diabetes_ DB - PRIME DP - Unbound Medicine ER -