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Impact of hormone replacement therapy on the histologic subtype of breast cancer.
Arch Gynecol Obstet. 2008 Nov; 278(5):443-9.AG

Abstract

OBJECTIVE

Postmenopausal hormone replacement therapy (HRT) is associated with an increase in breast cancer risk, which correlates to the duration of HRT use. We wanted to investigate a possible association between HRT use and the risk of a histologic subtype of breast cancer.

PATIENTS AND METHODS

From 1995 until 2004, 497 cases of primary ductal, lobular or ductulolobular breast cancer in postmenopausal women were diagnosed at the Department of Gynecology and Obstetrics, University Hospital Basel, Switzerland. The data was derived from patient's records. HRT ever use was defined as HRT use for > or =6 months.

RESULTS

Of the 99 cases of lobular cancer 72.7% were invasive lobular cancers, 21.2% were invasive ductulolobular cancers and 6.1% were lobular cancers in situ. Of the 398 cases of ductal cancer, 90.5% were invasive ductal cancers and 9.5% were ductal cancers in situ. Totally 144 women were HRT ever users, and 341 women were HRT never users. HRT status could not be defined in 12 women. HRT ever use was associated with an increased risk for lobular cancer (OR 1.67; 95% CI 1.02-2.73). Also, menopause due to bilateral oophorectomy was associated with an increased risk for lobular cancer (OR 2.42; 95% CI 1.06-5.54).

CONCLUSIONS

There is evidence that HRT as well as menopause due to bilateral oophorectomy may be associated with an increased risk for lobular cancer. This association is of major clinical relevance, since lobular breast cancer is more difficult to diagnose clinically and radiologically than ductal breast cancer.

Authors+Show Affiliations

Department of Gynecology and Obstetrics, University Hospital Basel, Spitalstrasse 21, Basel, Switzerland. rzanetti@uhbs.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18335229

Citation

Zanetti-Dällenbach, Rosanna A., et al. "Impact of Hormone Replacement Therapy On the Histologic Subtype of Breast Cancer." Archives of Gynecology and Obstetrics, vol. 278, no. 5, 2008, pp. 443-9.
Zanetti-Dällenbach RA, Krause EM, Lapaire O, et al. Impact of hormone replacement therapy on the histologic subtype of breast cancer. Arch Gynecol Obstet. 2008;278(5):443-9.
Zanetti-Dällenbach, R. A., Krause, E. M., Lapaire, O., Gueth, U., Holzgreve, W., & Wight, E. (2008). Impact of hormone replacement therapy on the histologic subtype of breast cancer. Archives of Gynecology and Obstetrics, 278(5), 443-9. https://doi.org/10.1007/s00404-008-0613-8
Zanetti-Dällenbach RA, et al. Impact of Hormone Replacement Therapy On the Histologic Subtype of Breast Cancer. Arch Gynecol Obstet. 2008;278(5):443-9. PubMed PMID: 18335229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of hormone replacement therapy on the histologic subtype of breast cancer. AU - Zanetti-Dällenbach,Rosanna A, AU - Krause,Elke M, AU - Lapaire,Olav, AU - Gueth,Uwe, AU - Holzgreve,Wolfgang, AU - Wight,Edward, Y1 - 2008/03/12/ PY - 2007/11/28/received PY - 2008/02/21/accepted PY - 2008/3/13/pubmed PY - 2009/2/12/medline PY - 2008/3/13/entrez SP - 443 EP - 9 JF - Archives of gynecology and obstetrics JO - Arch. Gynecol. Obstet. VL - 278 IS - 5 N2 - OBJECTIVE: Postmenopausal hormone replacement therapy (HRT) is associated with an increase in breast cancer risk, which correlates to the duration of HRT use. We wanted to investigate a possible association between HRT use and the risk of a histologic subtype of breast cancer. PATIENTS AND METHODS: From 1995 until 2004, 497 cases of primary ductal, lobular or ductulolobular breast cancer in postmenopausal women were diagnosed at the Department of Gynecology and Obstetrics, University Hospital Basel, Switzerland. The data was derived from patient's records. HRT ever use was defined as HRT use for > or =6 months. RESULTS: Of the 99 cases of lobular cancer 72.7% were invasive lobular cancers, 21.2% were invasive ductulolobular cancers and 6.1% were lobular cancers in situ. Of the 398 cases of ductal cancer, 90.5% were invasive ductal cancers and 9.5% were ductal cancers in situ. Totally 144 women were HRT ever users, and 341 women were HRT never users. HRT status could not be defined in 12 women. HRT ever use was associated with an increased risk for lobular cancer (OR 1.67; 95% CI 1.02-2.73). Also, menopause due to bilateral oophorectomy was associated with an increased risk for lobular cancer (OR 2.42; 95% CI 1.06-5.54). CONCLUSIONS: There is evidence that HRT as well as menopause due to bilateral oophorectomy may be associated with an increased risk for lobular cancer. This association is of major clinical relevance, since lobular breast cancer is more difficult to diagnose clinically and radiologically than ductal breast cancer. SN - 0932-0067 UR - https://www.unboundmedicine.com/medline/citation/18335229/Impact_of_hormone_replacement_therapy_on_the_histologic_subtype_of_breast_cancer_ L2 - https://dx.doi.org/10.1007/s00404-008-0613-8 DB - PRIME DP - Unbound Medicine ER -