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Efficiency of propolis extract against mitochondrial stress induced by antineoplasic agents (doxorubicin and vinblastin) in rats.

Abstract

To assess the oxidative stress and mitochondrial dysfunction associated with disease, toxic process and aging, in vivo and in vitro preventive effect of propolis extract against mitochondrial oxidative stress induced by two anticancer drugs (doxorubicin and vinblastin) have been investigated in female wistar rat using liver and heart mitochondria. The results show that doxorubicin and vinblastin altered mitochondrial functions as observed by a decrease in respiratory control value, an activation of swelling and overproduction of superoxide anion. Myocardial tissue from doxorubicin treated rats showed a marked increase in malondialdehyde production, a depletion of reduced glutathione contents and an inhibition of catalase and superoxide dismutase activities. Similar results were also observed in liver tissue. Pretreatment of rats with propolis extract (100 mg/kg/day po) (10(-4) M ip) administered 4 days prior to doxorubicin (20 mg/kg) and/or vinblastin (2 mg/kg) injection, substantially reduced the peroxidative damage in myocardium and hepatic tissues and markedly restored the tissues catalase and SOD activities. The results strongly suggest that propolis extract protects heart and liver tissues from oxidative stress by protecting the mitochondria.

Authors+Show Affiliations

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Laboratoire de Pharmacologie et Phytochimie, Faculté des Sciences, Université de Jijel. 18000 Jijel, Algérie.

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Source

MeSH

Animals
Antineoplastic Agents
Antioxidants
Catalase
Complex Mixtures
Disease Models, Animal
Doxorubicin
Drug-Related Side Effects and Adverse Reactions
Female
Lipid Peroxidation
Mitochondria, Heart
Mitochondria, Liver
Oxidative Stress
Propolis
Quercetin
Rats
Rats, Wistar
Superoxide Dismutase
Vinblastine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18335809