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Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia.
Am J Ophthalmol 2008; 145(6):1002-1006AJ

Abstract

PURPOSE

To determine the characteristics of patients with primary ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma associated with polyclonal hypergammaglobulinemia.

DESIGN

Case series study.

METHODS

Among 81 Japanese patients with primary ocular adnexal MALT lymphoma, seven patients (9%) were diagnosed with polyclonal hypergammaglobulinemia. Patient clinical data included a history of autoimmune disease and dissemination. Peripheral blood collected from all patients was analyzed for serum levels of rheumatoid factor, soluble interleukin-2 receptor (sIL-2R), and immunoglobulins at the time of diagnosis and after each treatment.

RESULTS

Seven patients with polyclonal hypergammaglobulinemia had elevated serum levels of rheumatoid factor, sIL-2R, immunoglobulin G (IgG), and immunoglobulin E (IgE) at the time of diagnosis. One patient had Sjogren syndrome. Six patients (86%) had a dissemination of the MALT lymphoma or lymphadenopathy at the time of diagnosis. Histopathologic examination of the patients with lymphadenopathy revealed not only MALT lymphoma but also secondary follicles. None of the seven patients showed improvement in serum levels of IgG, rheumatoid factor, or sIL-2R in spite of complete regression of the ocular lesions after radiotherapy. After administration of cyclophosphamide/doxorubicin/vincristine/prednisone and/or rituximab to three patients, all three showed improved serum levels of IgG, rheumatoid factor, and sIL-2R.

CONCLUSIONS

Patients with ocular adnexal MALT lymphoma and polyclonal hypergammaglobulinemia have elevated serum levels of rheumatoid factor, sIL-2R, and IgE, and high dissemination or lymphadenopathy. These unique characteristics may correlate with the systemic immunologic imbalances.

Authors+Show Affiliations

Department of Ophthalmology, National Hospital Organization, Nagoya Medical Center, 4-4-1 Sanno-maru, Naka-ku, Nagoya, Japan. ganiky@nnh.hosp.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18336788

Citation

Kubota, Toshinobu, et al. "Ocular Adnexal Mucosa-associated Lymphoid Tissue Lymphoma With Polyclonal Hypergammaglobulinemia." American Journal of Ophthalmology, vol. 145, no. 6, 2008, pp. 1002-1006.
Kubota T, Moritani S, Yoshino T, et al. Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. Am J Ophthalmol. 2008;145(6):1002-1006.
Kubota, T., Moritani, S., Yoshino, T., Nagai, H., & Terasaki, H. (2008). Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. American Journal of Ophthalmology, 145(6), pp. 1002-1006. doi:10.1016/j.ajo.2008.01.006.
Kubota T, et al. Ocular Adnexal Mucosa-associated Lymphoid Tissue Lymphoma With Polyclonal Hypergammaglobulinemia. Am J Ophthalmol. 2008;145(6):1002-1006. PubMed PMID: 18336788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. AU - Kubota,Toshinobu, AU - Moritani,Suzuko, AU - Yoshino,Tadashi, AU - Nagai,Hirokazu, AU - Terasaki,Hiroko, Y1 - 2008/03/12/ PY - 2007/11/10/received PY - 2008/01/07/revised PY - 2008/01/08/accepted PY - 2008/3/14/pubmed PY - 2008/6/25/medline PY - 2008/3/14/entrez SP - 1002 EP - 1006 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 145 IS - 6 N2 - PURPOSE: To determine the characteristics of patients with primary ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma associated with polyclonal hypergammaglobulinemia. DESIGN: Case series study. METHODS: Among 81 Japanese patients with primary ocular adnexal MALT lymphoma, seven patients (9%) were diagnosed with polyclonal hypergammaglobulinemia. Patient clinical data included a history of autoimmune disease and dissemination. Peripheral blood collected from all patients was analyzed for serum levels of rheumatoid factor, soluble interleukin-2 receptor (sIL-2R), and immunoglobulins at the time of diagnosis and after each treatment. RESULTS: Seven patients with polyclonal hypergammaglobulinemia had elevated serum levels of rheumatoid factor, sIL-2R, immunoglobulin G (IgG), and immunoglobulin E (IgE) at the time of diagnosis. One patient had Sjogren syndrome. Six patients (86%) had a dissemination of the MALT lymphoma or lymphadenopathy at the time of diagnosis. Histopathologic examination of the patients with lymphadenopathy revealed not only MALT lymphoma but also secondary follicles. None of the seven patients showed improvement in serum levels of IgG, rheumatoid factor, or sIL-2R in spite of complete regression of the ocular lesions after radiotherapy. After administration of cyclophosphamide/doxorubicin/vincristine/prednisone and/or rituximab to three patients, all three showed improved serum levels of IgG, rheumatoid factor, and sIL-2R. CONCLUSIONS: Patients with ocular adnexal MALT lymphoma and polyclonal hypergammaglobulinemia have elevated serum levels of rheumatoid factor, sIL-2R, and IgE, and high dissemination or lymphadenopathy. These unique characteristics may correlate with the systemic immunologic imbalances. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/18336788/Ocular_adnexal_mucosa_associated_lymphoid_tissue_lymphoma_with_polyclonal_hypergammaglobulinemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(08)00036-6 DB - PRIME DP - Unbound Medicine ER -