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Possible role for early-life immune insult including developmental immunotoxicity in chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME).

Abstract

Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME) in some countries, is a debilitating disease with a constellation of multi-system dysfunctions primarily involving the neurological, endocrine and immune systems. While substantial information is available concerning the complex dysfunction-associated symptoms of CFS, environmental origins of the disease have yet to be determined. Part of the dilemma in identifying the cause(s) has been the focus on biomarkers (hormones, neurotransmitters, cytokines, infectious agents) that are contemporary with later-life CFS episodes. Yet, recent investigations on the origins of environmental diseases of the neurological, endocrine, reproductive, respiratory and immune systems suggest that early life toxicologic and other insults are pivotal in producing later-life onset of symptoms. As with autism and childhood asthma, CFS can also occur in children where the causes are certainly early-life events. Immune dysfunction is recognized as part of the CFS phenotype but has received comparatively less attention than aberrant neurological or endocrine function. However, recent research results suggest that early life immune insults (ELII) including developmental immunotoxicity (DIT), which is induced by xenobiotics, may offer an important clue to the origin(s) of CFS. The developing immune system is a sensitive and novel target for environmental insult (xenobiotic, infectious agents, stress) with major ramifications for postnatal health risks. Additionally, many prenatal and early postnatal neurological lesions associated with postnatal neurobehavioral diseases are now recognized as linked to prenatal immune insult and inflammatory dysregulation. This review considers the potential role of ELII including DIT as an early-life component of later-life CFS.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. rrd1@cornell.edu

    Source

    Toxicology 247:1 2008 May 02 pg 61-72

    MeSH

    Adolescent
    Adult
    Age Factors
    Child
    Environmental Exposure
    Fatigue Syndrome, Chronic
    Female
    Humans
    Immune System
    Immunologic Tests
    Pregnancy
    Prenatal Exposure Delayed Effects
    Risk Factors
    Time Factors
    Xenobiotics

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    18336982

    Citation

    Dietert, Rodney R., and Janice M. Dietert. "Possible Role for Early-life Immune Insult Including Developmental Immunotoxicity in Chronic Fatigue Syndrome (CFS) or Myalgic Encephalomyelitis (ME)." Toxicology, vol. 247, no. 1, 2008, pp. 61-72.
    Dietert RR, Dietert JM. Possible role for early-life immune insult including developmental immunotoxicity in chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME). Toxicology. 2008;247(1):61-72.
    Dietert, R. R., & Dietert, J. M. (2008). Possible role for early-life immune insult including developmental immunotoxicity in chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME). Toxicology, 247(1), pp. 61-72. doi:10.1016/j.tox.2008.01.022.
    Dietert RR, Dietert JM. Possible Role for Early-life Immune Insult Including Developmental Immunotoxicity in Chronic Fatigue Syndrome (CFS) or Myalgic Encephalomyelitis (ME). Toxicology. 2008 May 2;247(1):61-72. PubMed PMID: 18336982.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Possible role for early-life immune insult including developmental immunotoxicity in chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME). AU - Dietert,Rodney R, AU - Dietert,Janice M, Y1 - 2008/02/08/ PY - 2007/11/25/received PY - 2008/01/06/revised PY - 2008/01/30/accepted PY - 2008/3/14/pubmed PY - 2008/5/30/medline PY - 2008/3/14/entrez SP - 61 EP - 72 JF - Toxicology JO - Toxicology VL - 247 IS - 1 N2 - Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME) in some countries, is a debilitating disease with a constellation of multi-system dysfunctions primarily involving the neurological, endocrine and immune systems. While substantial information is available concerning the complex dysfunction-associated symptoms of CFS, environmental origins of the disease have yet to be determined. Part of the dilemma in identifying the cause(s) has been the focus on biomarkers (hormones, neurotransmitters, cytokines, infectious agents) that are contemporary with later-life CFS episodes. Yet, recent investigations on the origins of environmental diseases of the neurological, endocrine, reproductive, respiratory and immune systems suggest that early life toxicologic and other insults are pivotal in producing later-life onset of symptoms. As with autism and childhood asthma, CFS can also occur in children where the causes are certainly early-life events. Immune dysfunction is recognized as part of the CFS phenotype but has received comparatively less attention than aberrant neurological or endocrine function. However, recent research results suggest that early life immune insults (ELII) including developmental immunotoxicity (DIT), which is induced by xenobiotics, may offer an important clue to the origin(s) of CFS. The developing immune system is a sensitive and novel target for environmental insult (xenobiotic, infectious agents, stress) with major ramifications for postnatal health risks. Additionally, many prenatal and early postnatal neurological lesions associated with postnatal neurobehavioral diseases are now recognized as linked to prenatal immune insult and inflammatory dysregulation. This review considers the potential role of ELII including DIT as an early-life component of later-life CFS. SN - 0300-483X UR - https://www.unboundmedicine.com/medline/citation/18336982/Possible_role_for_early_life_immune_insult_including_developmental_immunotoxicity_in_chronic_fatigue_syndrome__CFS__or_myalgic_encephalomyelitis__ME__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300-483X(08)00040-1 DB - PRIME DP - Unbound Medicine ER -