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Signaling via CNS cannabinoid receptors.
Mol Cell Endocrinol 2008; 286(1-2 Suppl 1):S60-5MC

Abstract

Because of the prominent psychoactive effects of cannabis and its preparations, much research has focused on the actions of cannabinoids, the primary psychoactive components of cannabis, on neuronal function. A convergence of research has identified (1) cannabinoid receptors, (2) endogenous compounds that activate these receptors (endocannabinoids), and (3) drugs that interact with these receptors and the proteins that synthesize and degrade the endocannabinoids. This review will first consider how endogenous cannabinoids signal through cannabinoid receptors and the various forms of synaptic plasticity mediated by endocannabinoids. Next the interactions between exogenous cannabinoids such as Delta9-tetrahydrocannabinol and endocannabinoids and endocannabinoid-mediated plasticity will be examined. Finally, a model will be presented that can explain the prominent psychoactivity of these plant-derived cannabinoids.

Authors+Show Affiliations

Department of Psychological and Brain Sciences, Indiana University, 1101 E. 10th St., Bloomington, IN 47401, USA. kmackie@indiana.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

18336996

Citation

Mackie, Ken. "Signaling Via CNS Cannabinoid Receptors." Molecular and Cellular Endocrinology, vol. 286, no. 1-2 Suppl 1, 2008, pp. S60-5.
Mackie K. Signaling via CNS cannabinoid receptors. Mol Cell Endocrinol. 2008;286(1-2 Suppl 1):S60-5.
Mackie, K. (2008). Signaling via CNS cannabinoid receptors. Molecular and Cellular Endocrinology, 286(1-2 Suppl 1), pp. S60-5. doi:10.1016/j.mce.2008.01.022.
Mackie K. Signaling Via CNS Cannabinoid Receptors. Mol Cell Endocrinol. 2008 Apr 16;286(1-2 Suppl 1):S60-5. PubMed PMID: 18336996.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Signaling via CNS cannabinoid receptors. A1 - Mackie,Ken, Y1 - 2008/02/06/ PY - 2007/12/18/received PY - 2008/01/25/revised PY - 2008/01/25/accepted PY - 2008/3/14/pubmed PY - 2008/7/12/medline PY - 2008/3/14/entrez SP - S60 EP - 5 JF - Molecular and cellular endocrinology JO - Mol. Cell. Endocrinol. VL - 286 IS - 1-2 Suppl 1 N2 - Because of the prominent psychoactive effects of cannabis and its preparations, much research has focused on the actions of cannabinoids, the primary psychoactive components of cannabis, on neuronal function. A convergence of research has identified (1) cannabinoid receptors, (2) endogenous compounds that activate these receptors (endocannabinoids), and (3) drugs that interact with these receptors and the proteins that synthesize and degrade the endocannabinoids. This review will first consider how endogenous cannabinoids signal through cannabinoid receptors and the various forms of synaptic plasticity mediated by endocannabinoids. Next the interactions between exogenous cannabinoids such as Delta9-tetrahydrocannabinol and endocannabinoids and endocannabinoid-mediated plasticity will be examined. Finally, a model will be presented that can explain the prominent psychoactivity of these plant-derived cannabinoids. SN - 0303-7207 UR - https://www.unboundmedicine.com/medline/citation/18336996/Signaling_via_CNS_cannabinoid_receptors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-7207(08)00032-4 DB - PRIME DP - Unbound Medicine ER -