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Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children.
Am J Respir Crit Care Med 2008; 177(12):1331-7AJ

Abstract

RATIONALE

In vitro studies, animal experiments, and human exposure studies have shown how ambient air pollution increases the risk of atopic diseases. However, results derived from observational studies are inconsistent.

OBJECTIVES

To assess the relationship between individual-based exposure to traffic-related air pollutants and allergic disease outcomes in a prospective birth cohort study during the first 6 years of life.

METHODS

We studied 2,860 children at the age of 4 years and 3,061 at the age of 6 years to investigate atopic diseases and allergic sensitization. Long-term exposure to particulate matter (PM(2.5)), PM(2.5) absorbance, and long-term exposure to nitrogen dioxide (NO(2)) was assessed at residential addresses using geographic information systems based regression models and air pollution measurements. The distance to the nearest main road was used as a surrogate for traffic-related air pollutants.

MEASUREMENTS AND MAIN RESULTS

Strong positive associations were found between the distance to the nearest main road and asthmatic bronchitis, hay fever, eczema, and sensitization. A distance-dependent relationship could be identified, with the highest odds ratios (ORs) for children living less than 50 m from busy streets. For PM(2.5) absorbance, statistically significant effects were found for asthmatic bronchitis (OR, 1.56; 95% confidence interval [CI], 1.03-2.37), hay fever (OR, 1.59; 95% CI, 1.11-2.27), and allergic sensitization to pollen (OR, 1.40; 95% CI, 1.20-1.64). NO(2) exposure was associated with eczema, whereas no association was found for allergic sensitization.

CONCLUSIONS

This study provides strong evidence for increased risk of atopic diseases and allergic sensitization when children are exposed to ambient particulate matter.

Authors+Show Affiliations

Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18337595

Citation

Morgenstern, Verena, et al. "Atopic Diseases, Allergic Sensitization, and Exposure to Traffic-related Air Pollution in Children." American Journal of Respiratory and Critical Care Medicine, vol. 177, no. 12, 2008, pp. 1331-7.
Morgenstern V, Zutavern A, Cyrys J, et al. Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children. Am J Respir Crit Care Med. 2008;177(12):1331-7.
Morgenstern, V., Zutavern, A., Cyrys, J., Brockow, I., Koletzko, S., Krämer, U., ... Heinrich, J. (2008). Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children. American Journal of Respiratory and Critical Care Medicine, 177(12), pp. 1331-7. doi:10.1164/rccm.200701-036OC.
Morgenstern V, et al. Atopic Diseases, Allergic Sensitization, and Exposure to Traffic-related Air Pollution in Children. Am J Respir Crit Care Med. 2008 Jun 15;177(12):1331-7. PubMed PMID: 18337595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children. AU - Morgenstern,Verena, AU - Zutavern,Anne, AU - Cyrys,Josef, AU - Brockow,Inken, AU - Koletzko,Sibylle, AU - Krämer,Ursula, AU - Behrendt,Heidrun, AU - Herbarth,Olf, AU - von Berg,Andrea, AU - Bauer,Carl Peter, AU - Wichmann,H-Erich, AU - Heinrich,Joachim, AU - ,, AU - ,, Y1 - 2008/03/12/ PY - 2008/3/14/pubmed PY - 2008/6/14/medline PY - 2008/3/14/entrez SP - 1331 EP - 7 JF - American journal of respiratory and critical care medicine JO - Am. J. Respir. Crit. Care Med. VL - 177 IS - 12 N2 - RATIONALE: In vitro studies, animal experiments, and human exposure studies have shown how ambient air pollution increases the risk of atopic diseases. However, results derived from observational studies are inconsistent. OBJECTIVES: To assess the relationship between individual-based exposure to traffic-related air pollutants and allergic disease outcomes in a prospective birth cohort study during the first 6 years of life. METHODS: We studied 2,860 children at the age of 4 years and 3,061 at the age of 6 years to investigate atopic diseases and allergic sensitization. Long-term exposure to particulate matter (PM(2.5)), PM(2.5) absorbance, and long-term exposure to nitrogen dioxide (NO(2)) was assessed at residential addresses using geographic information systems based regression models and air pollution measurements. The distance to the nearest main road was used as a surrogate for traffic-related air pollutants. MEASUREMENTS AND MAIN RESULTS: Strong positive associations were found between the distance to the nearest main road and asthmatic bronchitis, hay fever, eczema, and sensitization. A distance-dependent relationship could be identified, with the highest odds ratios (ORs) for children living less than 50 m from busy streets. For PM(2.5) absorbance, statistically significant effects were found for asthmatic bronchitis (OR, 1.56; 95% confidence interval [CI], 1.03-2.37), hay fever (OR, 1.59; 95% CI, 1.11-2.27), and allergic sensitization to pollen (OR, 1.40; 95% CI, 1.20-1.64). NO(2) exposure was associated with eczema, whereas no association was found for allergic sensitization. CONCLUSIONS: This study provides strong evidence for increased risk of atopic diseases and allergic sensitization when children are exposed to ambient particulate matter. SN - 1535-4970 UR - https://www.unboundmedicine.com/medline/citation/18337595/Atopic_diseases_allergic_sensitization_and_exposure_to_traffic_related_air_pollution_in_children_ L2 - http://www.atsjournals.org/doi/full/10.1164/rccm.200701-036OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -