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Sexual dysfunction in schizophrenia: focus on recent evidence.
Hum Psychopharmacol. 2008 Apr; 23(3):201-9.HP

Abstract

BACKGROUND

Antipsychotic medications are known to be commonly associated with sexual dysfunction. Sexual dysfunction is estimated to affect 30-80% of patients with schizophrenia and is a major cause of poor quality of life. However, few comparative studies on the sexual dysfunction effects associated with antipsychotic medication have been published and the effects of the newer atypical antipsychotics have been largely unexamined.

OBJECTIVE

This review aims to examine the latest evidence regarding the sexual function effects of different antipsychotic medications, particularly the newer prolactin-sparing drugs, quetiapine and aripiprazole, in patients with schizophrenia and schizoaffective psychosis.

METHODS

A literature search was conducted within PubMed/MEDLINE using the terms risperidone, haloperidol, clozapine, olanzapine, ziprasidone, quetiapine, aripiprazole; sexual dysfunction; schizophrenia. The results were limited to studies published since 2002.

RESULTS

Recently published studies show that the relative impact of antipsychotics on sexual dysfunction can be summarised as risperidone > typical antipsychotics (haloperidol) > olanzapine > quetiapine > aripiprazole.

CONCLUSIONS

The availability of prolactin-sparing antipsychotics should enable psychiatrists to consider and manage proactively the sexual function consequences of pharmacological intervention, thereby improving sexual side effects, which may lead to improved treatment adherence and psychiatric outcome in patients with schizophrenia.

Authors+Show Affiliations

South London & Maudsley NHS Foundation Trust Clinical Director, Sex & Relationship Problems Clinic, York Clinic, Guy's Hospital, London, UK. martin.baggaley@slam.nhs.uk

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18338766

Citation

Baggaley, Martin. "Sexual Dysfunction in Schizophrenia: Focus On Recent Evidence." Human Psychopharmacology, vol. 23, no. 3, 2008, pp. 201-9.
Baggaley M. Sexual dysfunction in schizophrenia: focus on recent evidence. Hum Psychopharmacol. 2008;23(3):201-9.
Baggaley, M. (2008). Sexual dysfunction in schizophrenia: focus on recent evidence. Human Psychopharmacology, 23(3), 201-9. https://doi.org/10.1002/hup.924
Baggaley M. Sexual Dysfunction in Schizophrenia: Focus On Recent Evidence. Hum Psychopharmacol. 2008;23(3):201-9. PubMed PMID: 18338766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sexual dysfunction in schizophrenia: focus on recent evidence. A1 - Baggaley,Martin, PY - 2008/3/15/pubmed PY - 2008/7/17/medline PY - 2008/3/15/entrez SP - 201 EP - 9 JF - Human psychopharmacology JO - Hum Psychopharmacol VL - 23 IS - 3 N2 - BACKGROUND: Antipsychotic medications are known to be commonly associated with sexual dysfunction. Sexual dysfunction is estimated to affect 30-80% of patients with schizophrenia and is a major cause of poor quality of life. However, few comparative studies on the sexual dysfunction effects associated with antipsychotic medication have been published and the effects of the newer atypical antipsychotics have been largely unexamined. OBJECTIVE: This review aims to examine the latest evidence regarding the sexual function effects of different antipsychotic medications, particularly the newer prolactin-sparing drugs, quetiapine and aripiprazole, in patients with schizophrenia and schizoaffective psychosis. METHODS: A literature search was conducted within PubMed/MEDLINE using the terms risperidone, haloperidol, clozapine, olanzapine, ziprasidone, quetiapine, aripiprazole; sexual dysfunction; schizophrenia. The results were limited to studies published since 2002. RESULTS: Recently published studies show that the relative impact of antipsychotics on sexual dysfunction can be summarised as risperidone > typical antipsychotics (haloperidol) > olanzapine > quetiapine > aripiprazole. CONCLUSIONS: The availability of prolactin-sparing antipsychotics should enable psychiatrists to consider and manage proactively the sexual function consequences of pharmacological intervention, thereby improving sexual side effects, which may lead to improved treatment adherence and psychiatric outcome in patients with schizophrenia. SN - 1099-1077 UR - https://www.unboundmedicine.com/medline/citation/18338766/Sexual_dysfunction_in_schizophrenia:_focus_on_recent_evidence_ L2 - https://doi.org/10.1002/hup.924 DB - PRIME DP - Unbound Medicine ER -