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Carbon post-microarrays for glucose sensors.
Biosens Bioelectron. 2008 Jun 15; 23(11):1637-44.BB

Abstract

A novel design and fabrication method of glucose sensors based on high aspect ratio carbon post-microarrays is reported in this paper. Apart from the fact that carbon has a wide electrochemical stability window, a major advantage of using carbon post-microarrays as working electrodes for an amperometric glucose sensor is the large reactive surface per unit footprint substrate area, improving sensitivity of the glucose sensor. The carbon post-microarrays were fabricated by carbon-microelectromechanical systems (C-MEMS) technology. Immobilization of enzyme onto the carbon post-electrodes was carried out through co-deposition of glucose oxidase (GOx) and electrochemically polymerized polypyrrole (PPy). Sensing performance of the glucose sensors with different post-heights and various post-densities was tested and compared. The carbon post-glucose sensors show a linear range from 0.5mM to 20mM and a response time of about 20s, which are comparable to the simulation result. Sensitivity per unit footprint substrate area as large as 2.02mA/(mMcm(2)) is achieved with the 140microm high (aspect ratio around 5:1) carbon post-samples, which is two times the sensitivity per unit footprint substrate area of the flat carbon films. This result is consistent with the hypothesis that the number of reaction sites scales with the reactive surface area of the sensor. Numerical simulation based on enzymatic reaction and glucose diffusion kinetics gives the optimum geometric design rules for the carbon post-glucose sensor. Glucose sensors with even higher sensitivity can be achieved utilizing higher carbon post-microarrays when technology evolution will permit it.

Authors+Show Affiliations

Department of Mechanical and Aerospace Engineering, University of California, Irvine, CA 92697, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18339532

Citation

Xu, Han, et al. "Carbon Post-microarrays for Glucose Sensors." Biosensors & Bioelectronics, vol. 23, no. 11, 2008, pp. 1637-44.
Xu H, Malladi K, Wang C, et al. Carbon post-microarrays for glucose sensors. Biosens Bioelectron. 2008;23(11):1637-44.
Xu, H., Malladi, K., Wang, C., Kulinsky, L., Song, M., & Madou, M. (2008). Carbon post-microarrays for glucose sensors. Biosensors & Bioelectronics, 23(11), 1637-44. https://doi.org/10.1016/j.bios.2008.01.031
Xu H, et al. Carbon Post-microarrays for Glucose Sensors. Biosens Bioelectron. 2008 Jun 15;23(11):1637-44. PubMed PMID: 18339532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carbon post-microarrays for glucose sensors. AU - Xu,Han, AU - Malladi,Kartikeya, AU - Wang,Chunlei, AU - Kulinsky,Lawrence, AU - Song,Mingje, AU - Madou,Marc, Y1 - 2008/02/08/ PY - 2007/09/12/received PY - 2008/01/07/revised PY - 2008/01/29/accepted PY - 2008/3/15/pubmed PY - 2008/8/20/medline PY - 2008/3/15/entrez SP - 1637 EP - 44 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 23 IS - 11 N2 - A novel design and fabrication method of glucose sensors based on high aspect ratio carbon post-microarrays is reported in this paper. Apart from the fact that carbon has a wide electrochemical stability window, a major advantage of using carbon post-microarrays as working electrodes for an amperometric glucose sensor is the large reactive surface per unit footprint substrate area, improving sensitivity of the glucose sensor. The carbon post-microarrays were fabricated by carbon-microelectromechanical systems (C-MEMS) technology. Immobilization of enzyme onto the carbon post-electrodes was carried out through co-deposition of glucose oxidase (GOx) and electrochemically polymerized polypyrrole (PPy). Sensing performance of the glucose sensors with different post-heights and various post-densities was tested and compared. The carbon post-glucose sensors show a linear range from 0.5mM to 20mM and a response time of about 20s, which are comparable to the simulation result. Sensitivity per unit footprint substrate area as large as 2.02mA/(mMcm(2)) is achieved with the 140microm high (aspect ratio around 5:1) carbon post-samples, which is two times the sensitivity per unit footprint substrate area of the flat carbon films. This result is consistent with the hypothesis that the number of reaction sites scales with the reactive surface area of the sensor. Numerical simulation based on enzymatic reaction and glucose diffusion kinetics gives the optimum geometric design rules for the carbon post-glucose sensor. Glucose sensors with even higher sensitivity can be achieved utilizing higher carbon post-microarrays when technology evolution will permit it. SN - 0956-5663 UR - https://www.unboundmedicine.com/medline/citation/18339532/Carbon_post_microarrays_for_glucose_sensors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(08)00052-3 DB - PRIME DP - Unbound Medicine ER -