TY - JOUR T1 - The MELD-Na is an independent short- and long-term prognostic predictor for hepatocellular carcinoma: a prospective survey. AU - Huo,T-I, AU - Lin,H-C, AU - Hsia,C-Y, AU - Huang,Y-H, AU - Wu,J-C, AU - Chiang,J-H, AU - Chiou,Y-Y, AU - Lui,W-Y, AU - Lee,P-C, AU - Lee,S-D, Y1 - 2008/03/12/ PY - 2007/11/05/received PY - 2007/12/17/revised PY - 2008/01/29/accepted PY - 2008/3/15/pubmed PY - 2009/1/16/medline PY - 2008/3/15/entrez SP - 882 EP - 9 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 40 IS - 11 N2 - BACKGROUND AND AIM: Serum sodium has been suggested to incorporate into the model for end-stage liver disease to enhance its prognostic ability for cirrhosis. A mathematical equation based on model for end-stage liver disease and sodium, known as "MELD-Na", was developed for outcome prediction for cirrhosis. The severity of liver cirrhosis is a key component to predict survival in patients with hepatocellular carcinoma. This study investigated the prognostic role of MELD-Na for hepatocellular carcinoma. PATIENTS AND METHODS: A total of 535 unselected hepatocellular carcinoma patients were prospectively enrolled to evaluate the performance of MELD-Na. RESULTS: The MELD-Na was better than model for end-stage liver disease in predicting 6-month mortality by comparing the area under receiver operating characteristic curve (0.782 vs. 0.761, p=0.101). MELD-Na, but not model for end-stage liver disease, was an independent predictor associated with 6-month mortality in multivariate logistic regression analysis (odds ratio: 1.14, p=0.001). In the survival analysis, MELD-Na also independently predicted mortality, with an additional risk of 4.3% per unit increment of the score (p<0.001). Patients with MELD-Na scores between 10 and 20 and scores >20 had 2.1-fold (p<0.001) and 7.5-fold (p<0.001) risk of mortality, respectively, compared to patients with a score <10 in the Cox proportional hazard model. CONCLUSION: The MELD-Na score is a feasible and independent prognostic predictor for both short- and long-term outcome predictions in patients with hepatocellular carcinoma. SN - 1878-3562 UR - https://www.unboundmedicine.com/medline/citation/18339595/The_MELD_Na_is_an_independent_short__and_long_term_prognostic_predictor_for_hepatocellular_carcinoma:_a_prospective_survey_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(08)00035-2 DB - PRIME DP - Unbound Medicine ER -