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Plasma levels of carotenoids, retinol and tocopherol and the risk of gastric cancer in Japan: a nested case-control study.

Abstract

Fruits and vegetables have been suggested to confer protection against diseases such as cancer through the effects of antioxidants, often represented by carotenoids. We investigated the impact of carotenoids, retinol and tocopherol on gastric cancer development in a large nested case-control study among Japanese with known Helicobacter pylori infection status. A total of 36 745 subjects aged 40-69 in the Japan Public Health Center-based Prospective Study who responded to the baseline questionnaire and provided blood samples in 1990-1995 were followed until 2004. Plasma levels of carotenoids in 511 gastric cancer cases and 511 matched controls were measured by high-performance liquid chromatography. Odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were estimated using conditional logistic regression models. Plasma level of beta-carotene was inversely associated with the risk of gastric cancer (compared with the lowest quartile: OR = 0.63, 95% CI = 0.31-0.75; OR = 0.48, 95% CI = 0.31-0.75 and OR = 0.46, 95% CI = 0.28-0.75, for quartile 2, 3 and 4, respectively, P(trend) < 0.01). Inverse associations were evident in men for alpha-carotene (P(trend) = 0.04) and beta-carotene (P(trend) < 0.01), but not in women, who had relatively higher plasma levels compared with men. We found no statistically significant association between plasma levels of lutein/zeaxanthin, lycopene, retinol, alpha- or gamma-tocopherol and gastric cancer risk. Our findings suggest that those who have very low plasma levels of alpha-carotene and beta-carotene are at a higher risk of gastric cancer.

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  • Authors+Show Affiliations

    ,

    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku 104-0045, Tokyo, Japan.

    , , , , , , ,

    Source

    Carcinogenesis 29:5 2008 May pg 1042-8

    MeSH

    Aged
    Alcohol Drinking
    Antioxidants
    Carotenoids
    Case-Control Studies
    Female
    Fruit
    Humans
    Japan
    Male
    Middle Aged
    Smoking
    Sodium Chloride
    Stomach Neoplasms
    Tocopherols
    Vegetables
    Vitamin A

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18339681

    Citation

    Persson, Christina, et al. "Plasma Levels of Carotenoids, Retinol and Tocopherol and the Risk of Gastric Cancer in Japan: a Nested Case-control Study." Carcinogenesis, vol. 29, no. 5, 2008, pp. 1042-8.
    Persson C, Sasazuki S, Inoue M, et al. Plasma levels of carotenoids, retinol and tocopherol and the risk of gastric cancer in Japan: a nested case-control study. Carcinogenesis. 2008;29(5):1042-8.
    Persson, C., Sasazuki, S., Inoue, M., Kurahashi, N., Iwasaki, M., Miura, T., ... Tsugane, S. (2008). Plasma levels of carotenoids, retinol and tocopherol and the risk of gastric cancer in Japan: a nested case-control study. Carcinogenesis, 29(5), pp. 1042-8. doi:10.1093/carcin/bgn072.
    Persson C, et al. Plasma Levels of Carotenoids, Retinol and Tocopherol and the Risk of Gastric Cancer in Japan: a Nested Case-control Study. Carcinogenesis. 2008;29(5):1042-8. PubMed PMID: 18339681.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Plasma levels of carotenoids, retinol and tocopherol and the risk of gastric cancer in Japan: a nested case-control study. AU - Persson,Christina, AU - Sasazuki,Shizuka, AU - Inoue,Manami, AU - Kurahashi,Norie, AU - Iwasaki,Motoki, AU - Miura,Tsutomu, AU - Ye,Weimin, AU - Tsugane,Shoichiro, AU - ,, Y1 - 2008/03/13/ PY - 2008/3/15/pubmed PY - 2008/8/2/medline PY - 2008/3/15/entrez SP - 1042 EP - 8 JF - Carcinogenesis JO - Carcinogenesis VL - 29 IS - 5 N2 - Fruits and vegetables have been suggested to confer protection against diseases such as cancer through the effects of antioxidants, often represented by carotenoids. We investigated the impact of carotenoids, retinol and tocopherol on gastric cancer development in a large nested case-control study among Japanese with known Helicobacter pylori infection status. A total of 36 745 subjects aged 40-69 in the Japan Public Health Center-based Prospective Study who responded to the baseline questionnaire and provided blood samples in 1990-1995 were followed until 2004. Plasma levels of carotenoids in 511 gastric cancer cases and 511 matched controls were measured by high-performance liquid chromatography. Odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were estimated using conditional logistic regression models. Plasma level of beta-carotene was inversely associated with the risk of gastric cancer (compared with the lowest quartile: OR = 0.63, 95% CI = 0.31-0.75; OR = 0.48, 95% CI = 0.31-0.75 and OR = 0.46, 95% CI = 0.28-0.75, for quartile 2, 3 and 4, respectively, P(trend) < 0.01). Inverse associations were evident in men for alpha-carotene (P(trend) = 0.04) and beta-carotene (P(trend) < 0.01), but not in women, who had relatively higher plasma levels compared with men. We found no statistically significant association between plasma levels of lutein/zeaxanthin, lycopene, retinol, alpha- or gamma-tocopherol and gastric cancer risk. Our findings suggest that those who have very low plasma levels of alpha-carotene and beta-carotene are at a higher risk of gastric cancer. SN - 1460-2180 UR - https://www.unboundmedicine.com/medline/citation/18339681/Plasma_levels_of_carotenoids_retinol_and_tocopherol_and_the_risk_of_gastric_cancer_in_Japan:_a_nested_case_control_study_ L2 - https://academic.oup.com/carcin/article-lookup/doi/10.1093/carcin/bgn072 DB - PRIME DP - Unbound Medicine ER -