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Abnormal hepatic function and splenomegaly on the newly diagnosed acute leukemia patients.
JNMA J Nepal Med Assoc. 2007 Oct-Dec; 46(168):165-9.JJ

Abstract

To evaluate the liver function, splenomegaly and related factors in the newly diagnosed acute leukemia patients. One hundred of fifty eight acute leukemia patients admitted in our hospital from March 2003 to April 2006 were studied. The related factors such as peripheral WBC count, bone marrow blasts, peripheral blasts, sex, age, AML, ALL affecting the liver function and splenomegaly were evaluated. Sixty two (39.24%) patients presented with splenomegaly. Twelve (7.59%) patients presented with hepatomegaly. Serum ALT was elevated in 54 (34.17%) patients. Similarly, serum AST, GGT, ALP, and Direct bilirubin were elevated in 26 (16.45%), 32 (20.25%), 20 (12.65%), and 22 (13.92%) patients, respectively. Low serum albumin was found in 40 (25.31%) patients. PT was prolonged in 62 (39.24%) patients. Statistical study shows that there is a relation between high WBC counts and elevated serum ALT (P<0.05) and high WBC counts and splenomegaly (P<0.05). Acute leukemia patients with leukocytosis are more prone to develop abnormal liver function and splenomegaly.

Authors+Show Affiliations

Department of Medicine, NAMS, Bir Hospital, Kathmandu, Nepal. drbishesh78@hotmail.comNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18340367

Citation

Sharma Poudel, B, and L Karki. "Abnormal Hepatic Function and Splenomegaly On the Newly Diagnosed Acute Leukemia Patients." JNMA; Journal of the Nepal Medical Association, vol. 46, no. 168, 2007, pp. 165-9.
Sharma Poudel B, Karki L. Abnormal hepatic function and splenomegaly on the newly diagnosed acute leukemia patients. JNMA J Nepal Med Assoc. 2007;46(168):165-9.
Sharma Poudel, B., & Karki, L. (2007). Abnormal hepatic function and splenomegaly on the newly diagnosed acute leukemia patients. JNMA; Journal of the Nepal Medical Association, 46(168), 165-9.
Sharma Poudel B, Karki L. Abnormal Hepatic Function and Splenomegaly On the Newly Diagnosed Acute Leukemia Patients. JNMA J Nepal Med Assoc. 2007 Oct-Dec;46(168):165-9. PubMed PMID: 18340367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal hepatic function and splenomegaly on the newly diagnosed acute leukemia patients. AU - Sharma Poudel,B, AU - Karki,L, PY - 2008/3/15/pubmed PY - 2008/8/30/medline PY - 2008/3/15/entrez SP - 165 EP - 9 JF - JNMA; journal of the Nepal Medical Association JO - JNMA J Nepal Med Assoc VL - 46 IS - 168 N2 - To evaluate the liver function, splenomegaly and related factors in the newly diagnosed acute leukemia patients. One hundred of fifty eight acute leukemia patients admitted in our hospital from March 2003 to April 2006 were studied. The related factors such as peripheral WBC count, bone marrow blasts, peripheral blasts, sex, age, AML, ALL affecting the liver function and splenomegaly were evaluated. Sixty two (39.24%) patients presented with splenomegaly. Twelve (7.59%) patients presented with hepatomegaly. Serum ALT was elevated in 54 (34.17%) patients. Similarly, serum AST, GGT, ALP, and Direct bilirubin were elevated in 26 (16.45%), 32 (20.25%), 20 (12.65%), and 22 (13.92%) patients, respectively. Low serum albumin was found in 40 (25.31%) patients. PT was prolonged in 62 (39.24%) patients. Statistical study shows that there is a relation between high WBC counts and elevated serum ALT (P<0.05) and high WBC counts and splenomegaly (P<0.05). Acute leukemia patients with leukocytosis are more prone to develop abnormal liver function and splenomegaly. SN - 0028-2715 UR - https://www.unboundmedicine.com/medline/citation/18340367/Abnormal_hepatic_function_and_splenomegaly_on_the_newly_diagnosed_acute_leukemia_patients_ L2 - http://www.diseaseinfosearch.org/result/6790 DB - PRIME DP - Unbound Medicine ER -