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An open study of Triphasil and Diane 50 in the treatment of acne.
Australas J Dermatol. 1991; 32(1):51-4.AJ

Abstract

Levonorgestrel, as used in oral contraceptives, has antiovulatory activity at doses far lower than those producing androgenic effects. Triphasil, containing levonorgestrel was compared with Diane, containing cyproterone acetate in a trial of acne treatment. Twenty closely matched patients were alternatively allocated to 6 months of Triphasil or Diane treatment. Both groups had a 72% reduction in acne counts. Assays of total testosterone, androgen index, free testosterone, dehydroepiandrosterone sulphate and androstenedione showed significant reduction on treatment and sex hormone binding globulin was raised. All hormonal changes were more marked in the Diane group. Side effects caused only one withdrawal from the trial.

Authors+Show Affiliations

Department of Dermatology, Auckland Hospital, New Zealand.

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1834045

Citation

Wishart, J M.. "An Open Study of Triphasil and Diane 50 in the Treatment of Acne." The Australasian Journal of Dermatology, vol. 32, no. 1, 1991, pp. 51-4.
Wishart JM. An open study of Triphasil and Diane 50 in the treatment of acne. Australas J Dermatol. 1991;32(1):51-4.
Wishart, J. M. (1991). An open study of Triphasil and Diane 50 in the treatment of acne. The Australasian Journal of Dermatology, 32(1), 51-4.
Wishart JM. An Open Study of Triphasil and Diane 50 in the Treatment of Acne. Australas J Dermatol. 1991;32(1):51-4. PubMed PMID: 1834045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An open study of Triphasil and Diane 50 in the treatment of acne. A1 - Wishart,J M, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez KW - Acne KW - Androgens KW - Biology KW - Cholesterol KW - Clinical Research KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Estrogen KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Dehydroepiandrosterone KW - Dermatitis KW - Dermatological Effects KW - Developed Countries KW - Diseases KW - Endocrine System KW - Ethinyl Estradiol KW - Family Planning KW - Hirsutism KW - Hormones KW - Human Volunteers KW - Levonorgestrel KW - Lipids KW - New Zealand KW - Oceania KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Oral Contraceptives, Phasic KW - Physiology KW - Research Methodology KW - Research Report KW - Signs And Symptoms KW - Testosterone SP - 51 EP - 4 JF - The Australasian journal of dermatology JO - Australas J Dermatol VL - 32 IS - 1 N2 - Levonorgestrel, as used in oral contraceptives, has antiovulatory activity at doses far lower than those producing androgenic effects. Triphasil, containing levonorgestrel was compared with Diane, containing cyproterone acetate in a trial of acne treatment. Twenty closely matched patients were alternatively allocated to 6 months of Triphasil or Diane treatment. Both groups had a 72% reduction in acne counts. Assays of total testosterone, androgen index, free testosterone, dehydroepiandrosterone sulphate and androstenedione showed significant reduction on treatment and sex hormone binding globulin was raised. All hormonal changes were more marked in the Diane group. Side effects caused only one withdrawal from the trial. SN - 0004-8380 UR - https://www.unboundmedicine.com/medline/citation/1834045/An_open_study_of_Triphasil_and_Diane_50_in_the_treatment_of_acne_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0004-8380&date=1991&volume=32&issue=1&spage=51 DB - PRIME DP - Unbound Medicine ER -