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Endogenous sex hormones and C-reactive protein in healthy postmenopausal women.
J Intern Med. 2008 Sep; 264(3):245-53.JI

Abstract

BACKGROUND

Oral oestrogen replacement therapy increases levels of C-reactive protein (CRP). CRP is an established strong predictor of cardiovascular events. It is unknown whether endogenous oestrogen levels are associated with CRP. We therefore studied the relationship between endogenous sex hormones and CRP in healthy postmenopausal women emphasizing the role of body composition as peripheral fat is both a main source of oestrogen production after menopause and an endocrine tissue with inflammatory activities.

SUBJECTS AND METHODS

The study population comprised 889 women participating in the PROSPECT study, an ongoing population-based cohort study. Information on risk factors was collected by questionnaires and clinical examination. Endogenous sex hormone levels and CRP were measured with double antibody radio immuno assay (RIA) from fasting plasma samples. In this cross-sectional study, associations between risk factors and lnCRP were studied using linear regression models.

RESULTS

Increases in oestrone and free oestradiol levels and the free androgen index were related to an increase in lnCRP of 1.19, 1.23 and 1.21 mg dL(-1) respectively. Body mass index (BMI), waist circumference and physical activity were strongly related to CRP levels, independent of age and other cardiovascular risk factors. Levels of all sex steroids but dehydroepiandrostenedione decreased with age. In age-adjusted analyses, an increase in waist circumference or BMI by one quartile was associated with a 1.28-fold and 1.26-fold increase in CRP. The relationship between endogenous hormones and CRP was modestly attenuated but remained highly significant after adjustment for body composition, physical activity and other traditional cardiovascular risk factors.

CONCLUSIONS

Our findings show that in postmenopausal women high levels of endogenous oestrogenic and androgenic sex steroids coincide with high CRP levels. This was only explained in part by markers of body composition or intra-abdominal fat.

Authors+Show Affiliations

Medizinische Klinik und Poliklinik I/II and Cardiovascular Center, University of Würzburg, Würzburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18341528

Citation

Störk, S, et al. "Endogenous Sex Hormones and C-reactive Protein in Healthy Postmenopausal Women." Journal of Internal Medicine, vol. 264, no. 3, 2008, pp. 245-53.
Störk S, Bots ML, Grobbee DE, et al. Endogenous sex hormones and C-reactive protein in healthy postmenopausal women. J Intern Med. 2008;264(3):245-53.
Störk, S., Bots, M. L., Grobbee, D. E., & van der Schouw, Y. T. (2008). Endogenous sex hormones and C-reactive protein in healthy postmenopausal women. Journal of Internal Medicine, 264(3), 245-53. https://doi.org/10.1111/j.1365-2796.2008.01946.x
Störk S, et al. Endogenous Sex Hormones and C-reactive Protein in Healthy Postmenopausal Women. J Intern Med. 2008;264(3):245-53. PubMed PMID: 18341528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endogenous sex hormones and C-reactive protein in healthy postmenopausal women. AU - Störk,S, AU - Bots,M L, AU - Grobbee,D E, AU - van der Schouw,Y T, Y1 - 2008/03/13/ PY - 2008/3/18/pubmed PY - 2009/1/8/medline PY - 2008/3/18/entrez SP - 245 EP - 53 JF - Journal of internal medicine JO - J Intern Med VL - 264 IS - 3 N2 - BACKGROUND: Oral oestrogen replacement therapy increases levels of C-reactive protein (CRP). CRP is an established strong predictor of cardiovascular events. It is unknown whether endogenous oestrogen levels are associated with CRP. We therefore studied the relationship between endogenous sex hormones and CRP in healthy postmenopausal women emphasizing the role of body composition as peripheral fat is both a main source of oestrogen production after menopause and an endocrine tissue with inflammatory activities. SUBJECTS AND METHODS: The study population comprised 889 women participating in the PROSPECT study, an ongoing population-based cohort study. Information on risk factors was collected by questionnaires and clinical examination. Endogenous sex hormone levels and CRP were measured with double antibody radio immuno assay (RIA) from fasting plasma samples. In this cross-sectional study, associations between risk factors and lnCRP were studied using linear regression models. RESULTS: Increases in oestrone and free oestradiol levels and the free androgen index were related to an increase in lnCRP of 1.19, 1.23 and 1.21 mg dL(-1) respectively. Body mass index (BMI), waist circumference and physical activity were strongly related to CRP levels, independent of age and other cardiovascular risk factors. Levels of all sex steroids but dehydroepiandrostenedione decreased with age. In age-adjusted analyses, an increase in waist circumference or BMI by one quartile was associated with a 1.28-fold and 1.26-fold increase in CRP. The relationship between endogenous hormones and CRP was modestly attenuated but remained highly significant after adjustment for body composition, physical activity and other traditional cardiovascular risk factors. CONCLUSIONS: Our findings show that in postmenopausal women high levels of endogenous oestrogenic and androgenic sex steroids coincide with high CRP levels. This was only explained in part by markers of body composition or intra-abdominal fat. SN - 1365-2796 UR - https://www.unboundmedicine.com/medline/citation/18341528/Endogenous_sex_hormones_and_C_reactive_protein_in_healthy_postmenopausal_women_ L2 - https://doi.org/10.1111/j.1365-2796.2008.01946.x DB - PRIME DP - Unbound Medicine ER -