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Patients with systemic autoimmune diseases could not distinguish comorbidities from their index disease.
J Clin Epidemiol 2008; 61(7):654-62JC

Abstract

OBJECTIVE

To assess the construct validity of the Self-Administered Comorbidity Questionnaire (SCQ) in patients with systemic sclerosis (SSc) and systemic lupus erythematosus (SLE).

METHODS

The SCQ was modified for the SSc cohort to emphasize the objective of recording problems other than the patients' scleroderma. It was administered to 406 SSc and 147 SLE patients. Construct validity of the SCQ was evaluated separately in the SSc and SLE cohorts by testing the hypotheses that a valid comorbidity index should correlate with age and health-related quality of life (Medical Outcomes Trust Short Form 36 [SF 36]) but not with disease-specific variables.

RESULTS

The SCQ score correlated with age in the SSc patients only (Tau B=0.37, P<0.001) and not in the SLE patients. It correlated with the SF 36 in both SSc and SLE. However, it also correlated with several disease-related variables. There was significant overlap between reports of comorbidities and disease-related problems in the SSc cohort.

CONCLUSION

Patients with systemic autoimmune diseases cannot distinguish true comorbidities from conditions related to their index disease and, as such, a self-administered comorbidity questionnaire does not appear useful in these diseases.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18342489

Citation

Hudson, Marie, et al. "Patients With Systemic Autoimmune Diseases Could Not Distinguish Comorbidities From Their Index Disease." Journal of Clinical Epidemiology, vol. 61, no. 7, 2008, pp. 654-62.
Hudson M, Bernatsky S, Taillefer S, et al. Patients with systemic autoimmune diseases could not distinguish comorbidities from their index disease. J Clin Epidemiol. 2008;61(7):654-62.
Hudson, M., Bernatsky, S., Taillefer, S., Fortin, P. R., Wither, J., & Baron, M. (2008). Patients with systemic autoimmune diseases could not distinguish comorbidities from their index disease. Journal of Clinical Epidemiology, 61(7), pp. 654-62. doi:10.1016/j.jclinepi.2007.08.010.
Hudson M, et al. Patients With Systemic Autoimmune Diseases Could Not Distinguish Comorbidities From Their Index Disease. J Clin Epidemiol. 2008;61(7):654-62. PubMed PMID: 18342489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patients with systemic autoimmune diseases could not distinguish comorbidities from their index disease. AU - Hudson,Marie, AU - Bernatsky,Sasha, AU - Taillefer,Suzanne, AU - Fortin,Paul R, AU - Wither,Joan, AU - Baron,Murray, AU - ,, AU - ,, Y1 - 2008/03/14/ PY - 2007/04/03/received PY - 2007/07/22/revised PY - 2007/08/03/accepted PY - 2008/3/18/pubmed PY - 2008/8/8/medline PY - 2008/3/18/entrez SP - 654 EP - 62 JF - Journal of clinical epidemiology JO - J Clin Epidemiol VL - 61 IS - 7 N2 - OBJECTIVE: To assess the construct validity of the Self-Administered Comorbidity Questionnaire (SCQ) in patients with systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). METHODS: The SCQ was modified for the SSc cohort to emphasize the objective of recording problems other than the patients' scleroderma. It was administered to 406 SSc and 147 SLE patients. Construct validity of the SCQ was evaluated separately in the SSc and SLE cohorts by testing the hypotheses that a valid comorbidity index should correlate with age and health-related quality of life (Medical Outcomes Trust Short Form 36 [SF 36]) but not with disease-specific variables. RESULTS: The SCQ score correlated with age in the SSc patients only (Tau B=0.37, P<0.001) and not in the SLE patients. It correlated with the SF 36 in both SSc and SLE. However, it also correlated with several disease-related variables. There was significant overlap between reports of comorbidities and disease-related problems in the SSc cohort. CONCLUSION: Patients with systemic autoimmune diseases cannot distinguish true comorbidities from conditions related to their index disease and, as such, a self-administered comorbidity questionnaire does not appear useful in these diseases. SN - 0895-4356 UR - https://www.unboundmedicine.com/medline/citation/18342489/Patients_with_systemic_autoimmune_diseases_could_not_distinguish_comorbidities_from_their_index_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0895-4356(07)00302-2 DB - PRIME DP - Unbound Medicine ER -