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Controlling granule size by granulation liquid feed pulsing.
Int J Pharm. 2008 Jun 05; 357(1-2):132-8.IJ

Abstract

The effects of inlet air humidity, granulation liquid feed rate and granulation liquid feed pulsing on the particle-size distribution of final granules were studied in a laboratory scale fluid-bed granulator using a central composite study design. The factors examined were modelled using three different particle-size measurement techniques (sieve analysis, laser light diffraction and the spatial filtering technique). Best goodness of fit (R2=0.94) and goodness of prediction (Q2=0.90) values were obtained using particle-size results of the spatial filtering technique. Increasing inlet air humidity and granulation liquid feed rate resulted in greater median granule size, as expected. When pulsing (interruption of granulation liquid feed in predetermined sequences) was used, the median granule size decreased clearly. This effect was strong, especially with high inlet air humidity and rapid liquid feed rate processes. Granulation liquid feed pulsing is an effective way to modify the particle size of final granules. Pulsing can be used as a controlling tool to compensate for excessive moisture content in the granulation process.

Authors+Show Affiliations

Orion Corporation Orion Pharma, Orionintie 1, P.O. Box 65, FIN-02101 Espoo, Finland. tero.narvanen@orionpharma.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18343060

Citation

Närvänen, Tero, et al. "Controlling Granule Size By Granulation Liquid Feed Pulsing." International Journal of Pharmaceutics, vol. 357, no. 1-2, 2008, pp. 132-8.
Närvänen T, Lipsanen T, Antikainen O, et al. Controlling granule size by granulation liquid feed pulsing. Int J Pharm. 2008;357(1-2):132-8.
Närvänen, T., Lipsanen, T., Antikainen, O., Räikkönen, H., & Yliruusi, J. (2008). Controlling granule size by granulation liquid feed pulsing. International Journal of Pharmaceutics, 357(1-2), 132-8. https://doi.org/10.1016/j.ijpharm.2008.01.060
Närvänen T, et al. Controlling Granule Size By Granulation Liquid Feed Pulsing. Int J Pharm. 2008 Jun 5;357(1-2):132-8. PubMed PMID: 18343060.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Controlling granule size by granulation liquid feed pulsing. AU - Närvänen,Tero, AU - Lipsanen,Tanja, AU - Antikainen,Osmo, AU - Räikkönen,Heikki, AU - Yliruusi,Jouko, Y1 - 2008/02/09/ PY - 2007/08/09/received PY - 2007/12/21/revised PY - 2008/01/25/accepted PY - 2008/3/18/pubmed PY - 2008/8/30/medline PY - 2008/3/18/entrez SP - 132 EP - 8 JF - International journal of pharmaceutics JO - Int J Pharm VL - 357 IS - 1-2 N2 - The effects of inlet air humidity, granulation liquid feed rate and granulation liquid feed pulsing on the particle-size distribution of final granules were studied in a laboratory scale fluid-bed granulator using a central composite study design. The factors examined were modelled using three different particle-size measurement techniques (sieve analysis, laser light diffraction and the spatial filtering technique). Best goodness of fit (R2=0.94) and goodness of prediction (Q2=0.90) values were obtained using particle-size results of the spatial filtering technique. Increasing inlet air humidity and granulation liquid feed rate resulted in greater median granule size, as expected. When pulsing (interruption of granulation liquid feed in predetermined sequences) was used, the median granule size decreased clearly. This effect was strong, especially with high inlet air humidity and rapid liquid feed rate processes. Granulation liquid feed pulsing is an effective way to modify the particle size of final granules. Pulsing can be used as a controlling tool to compensate for excessive moisture content in the granulation process. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/18343060/Controlling_granule_size_by_granulation_liquid_feed_pulsing_ DB - PRIME DP - Unbound Medicine ER -