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Molecular basis of the mammalian pressure-sensitive ion channels: focus on vascular mechanotransduction.
Prog Biophys Mol Biol. 2008 Jun-Jul; 97(2-3):180-95.PB

Abstract

Mechano-gated ion channels are implicated in a variety of neurosensory functions ranging from touch sensitivity to hearing. In the heart, rhythm disturbance subsequent to mechanical effects is also associated with the activation of stretch-sensitive ion channels. Arterial autoregulation in response to hemodynamic stimuli, a vital process required for protection against hypertension-induced injury, is similarly dependent on the activity of force-sensitive ion channels. Seminal work in prokaryotes and invertebrates, including the nematode Caenorhabditis elegans and the fruit fly drosophila, greatly helped to identify the molecular basis of volume regulation, hearing and touch sensitivity. In mammals, more recent findings have indicated that members of several structural family of ion channels, namely the transient receptor potential (TRP) channels, the amiloride-sensitive ENaC/ASIC channels and the potassium channels K2P and Kir are involved in cellular mechanotransduction. In the present review, we will focus on the molecular and functional properties of these channel subunits and will emphasize on their role in the pressure-dependent arterial myogenic constriction and the flow-mediated vasodilation.

Authors+Show Affiliations

Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18343483

Citation

Folgering, Joost H A., et al. "Molecular Basis of the Mammalian Pressure-sensitive Ion Channels: Focus On Vascular Mechanotransduction." Progress in Biophysics and Molecular Biology, vol. 97, no. 2-3, 2008, pp. 180-95.
Folgering JH, Sharif-Naeini R, Dedman A, et al. Molecular basis of the mammalian pressure-sensitive ion channels: focus on vascular mechanotransduction. Prog Biophys Mol Biol. 2008;97(2-3):180-95.
Folgering, J. H., Sharif-Naeini, R., Dedman, A., Patel, A., Delmas, P., & Honoré, E. (2008). Molecular basis of the mammalian pressure-sensitive ion channels: focus on vascular mechanotransduction. Progress in Biophysics and Molecular Biology, 97(2-3), 180-95. https://doi.org/10.1016/j.pbiomolbio.2008.02.006
Folgering JH, et al. Molecular Basis of the Mammalian Pressure-sensitive Ion Channels: Focus On Vascular Mechanotransduction. Prog Biophys Mol Biol. 2008 Jun-Jul;97(2-3):180-95. PubMed PMID: 18343483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular basis of the mammalian pressure-sensitive ion channels: focus on vascular mechanotransduction. AU - Folgering,Joost H A, AU - Sharif-Naeini,Reza, AU - Dedman,Alexandra, AU - Patel,Amanda, AU - Delmas,Patrick, AU - Honoré,Eric, Y1 - 2008/02/13/ PY - 2008/3/18/pubmed PY - 2008/9/16/medline PY - 2008/3/18/entrez SP - 180 EP - 95 JF - Progress in biophysics and molecular biology JO - Prog Biophys Mol Biol VL - 97 IS - 2-3 N2 - Mechano-gated ion channels are implicated in a variety of neurosensory functions ranging from touch sensitivity to hearing. In the heart, rhythm disturbance subsequent to mechanical effects is also associated with the activation of stretch-sensitive ion channels. Arterial autoregulation in response to hemodynamic stimuli, a vital process required for protection against hypertension-induced injury, is similarly dependent on the activity of force-sensitive ion channels. Seminal work in prokaryotes and invertebrates, including the nematode Caenorhabditis elegans and the fruit fly drosophila, greatly helped to identify the molecular basis of volume regulation, hearing and touch sensitivity. In mammals, more recent findings have indicated that members of several structural family of ion channels, namely the transient receptor potential (TRP) channels, the amiloride-sensitive ENaC/ASIC channels and the potassium channels K2P and Kir are involved in cellular mechanotransduction. In the present review, we will focus on the molecular and functional properties of these channel subunits and will emphasize on their role in the pressure-dependent arterial myogenic constriction and the flow-mediated vasodilation. SN - 0079-6107 UR - https://www.unboundmedicine.com/medline/citation/18343483/Molecular_basis_of_the_mammalian_pressure_sensitive_ion_channels:_focus_on_vascular_mechanotransduction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0079-6107(08)00016-3 DB - PRIME DP - Unbound Medicine ER -