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Effect of a hypocaloric diet on serum visfatin in obese non-diabetic patients.
Nutrition. 2008 Jun; 24(6):517-21.N

Abstract

OBJECTIVE

Obesity and insulin resistance are associated with classic and new cardiovascular risk factors, such as inflammatory markers and adipocytokines. The aim of this study was to examine whether weight reduction could change visfatin serum concentrations in obese patients.

METHODS

This was an interventional longitudinal study analyzing a population of 80 obese non-diabetic outpatients. Weight, blood pressure, fasting serum glucose, C-reactive protein, plasma insulin, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerols, and insulin resistance (homeostatic model assessment) were measured before and after 3 mo on a hypocaloric diet.

RESULTS

Eighty patients were enrolled. The mean age was 46.7 +/- 16.7 y, the mean body mass index was 34.1 +/- 4.8 kg/m(2), with 20 men (25%) and 60 women (75%). After 3 mo on a hypocaloric diet, body mass index, fat mass, waist circumference, systolic blood pressure, fasting serum glucose, total cholesterol, and low-density lipoprotein cholesterol decreased. The serum concentration of visfatin decreased with weight loss (112.14 +/- 70.2 versus 99.4 +/- 58.1 ng/mL, P < 0.05). In the multivariate analysis of visfatin concentration before and after treatment, as a dependent variable, only age remained an independent predictor in the model (F = 12.5, P < 0.02), with an inverse correlation: visfatin decreased 4.1 g/mL (F = 12.5, P < 0.05) and 3.7 g/mL (95% confidence interval 1.2-6.1), respectively, for each year of age.

CONCLUSION

Weight reduction after a 3-mo period of a hypocaloric diet is associated with a significant decrease in circulating serum concentrations of the novel adipokine visfatin in obese subjects. Visfatin is inversely correlated with age.

Authors+Show Affiliations

Institute of Endocrinology and Nutrition, University of Valladolid, and Clinical Nutrition Research Unit (RD056/0013), Hospital Rio Hortega, Valladolid, Spain. dadluis@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18343636

Citation

de Luis, Daniel A., et al. "Effect of a Hypocaloric Diet On Serum Visfatin in Obese Non-diabetic Patients." Nutrition (Burbank, Los Angeles County, Calif.), vol. 24, no. 6, 2008, pp. 517-21.
de Luis DA, Gonzalez Sagrado M, Conde R, et al. Effect of a hypocaloric diet on serum visfatin in obese non-diabetic patients. Nutrition. 2008;24(6):517-21.
de Luis, D. A., Gonzalez Sagrado, M., Conde, R., Aller, R., Izaola, O., & Romero, E. (2008). Effect of a hypocaloric diet on serum visfatin in obese non-diabetic patients. Nutrition (Burbank, Los Angeles County, Calif.), 24(6), 517-21. https://doi.org/10.1016/j.nut.2008.01.052
de Luis DA, et al. Effect of a Hypocaloric Diet On Serum Visfatin in Obese Non-diabetic Patients. Nutrition. 2008;24(6):517-21. PubMed PMID: 18343636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a hypocaloric diet on serum visfatin in obese non-diabetic patients. AU - de Luis,Daniel A, AU - Gonzalez Sagrado,Manuel, AU - Conde,Rosa, AU - Aller,Rocio, AU - Izaola,Olatz, AU - Romero,Enrique, Y1 - 2008/03/17/ PY - 2007/08/16/received PY - 2007/12/12/revised PY - 2008/01/28/accepted PY - 2008/3/18/pubmed PY - 2008/10/23/medline PY - 2008/3/18/entrez SP - 517 EP - 21 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 24 IS - 6 N2 - OBJECTIVE: Obesity and insulin resistance are associated with classic and new cardiovascular risk factors, such as inflammatory markers and adipocytokines. The aim of this study was to examine whether weight reduction could change visfatin serum concentrations in obese patients. METHODS: This was an interventional longitudinal study analyzing a population of 80 obese non-diabetic outpatients. Weight, blood pressure, fasting serum glucose, C-reactive protein, plasma insulin, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerols, and insulin resistance (homeostatic model assessment) were measured before and after 3 mo on a hypocaloric diet. RESULTS: Eighty patients were enrolled. The mean age was 46.7 +/- 16.7 y, the mean body mass index was 34.1 +/- 4.8 kg/m(2), with 20 men (25%) and 60 women (75%). After 3 mo on a hypocaloric diet, body mass index, fat mass, waist circumference, systolic blood pressure, fasting serum glucose, total cholesterol, and low-density lipoprotein cholesterol decreased. The serum concentration of visfatin decreased with weight loss (112.14 +/- 70.2 versus 99.4 +/- 58.1 ng/mL, P < 0.05). In the multivariate analysis of visfatin concentration before and after treatment, as a dependent variable, only age remained an independent predictor in the model (F = 12.5, P < 0.02), with an inverse correlation: visfatin decreased 4.1 g/mL (F = 12.5, P < 0.05) and 3.7 g/mL (95% confidence interval 1.2-6.1), respectively, for each year of age. CONCLUSION: Weight reduction after a 3-mo period of a hypocaloric diet is associated with a significant decrease in circulating serum concentrations of the novel adipokine visfatin in obese subjects. Visfatin is inversely correlated with age. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/18343636/Effect_of_a_hypocaloric_diet_on_serum_visfatin_in_obese_non_diabetic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(08)00039-7 DB - PRIME DP - Unbound Medicine ER -