Tags

Type your tag names separated by a space and hit enter

Aberrant expression of CD7 in myeloblasts is highly associated with de novo acute myeloid leukemias with FLT3/ITD mutation.
Am J Clin Pathol. 2008 Apr; 129(4):624-9.AJ

Abstract

Acute myeloid leukemia (AML) with normal cytogenetics represents approximately 40% to 50% of de novo AML. This heterogeneous AML subgroup constitutes the single largest cytogenetic group with an intermediate prognosis. Previous studies have suggested that the Fms-like tyrosine kinase-3 internal tandem duplication (FLT3/ITD) mutation-positive de novo AML may represent a distinctive subgroup of AML. We analyzed the clinical and pathologic features of 15 cases of de novo AML with normal cytogenetics and with the FLT3/ITD mutation. In comparison with patients with AML without the FLT3/ITD mutation, patients with FLT3/ITD+ AML are relatively younger, more often have marked peripheral leukocytosis with a higher number of circulating blasts at initial examination, more often have minimal differentiation morphologic features, more frequently have abnormal CD7 coexpression, and have poorer outcome. Close association of aberrant CD7 expression and FLT3/ITD mutation in the myeloblasts of FLT3/ITD+ AML suggests that FLT3/ITD- mediated leukemic transformation occurs in the more early stage of myeloid progenitor cells.

Authors+Show Affiliations

Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18343790

Citation

Rausei-Mills, Veronica, et al. "Aberrant Expression of CD7 in Myeloblasts Is Highly Associated With De Novo Acute Myeloid Leukemias With FLT3/ITD Mutation." American Journal of Clinical Pathology, vol. 129, no. 4, 2008, pp. 624-9.
Rausei-Mills V, Chang KL, Gaal KK, et al. Aberrant expression of CD7 in myeloblasts is highly associated with de novo acute myeloid leukemias with FLT3/ITD mutation. Am J Clin Pathol. 2008;129(4):624-9.
Rausei-Mills, V., Chang, K. L., Gaal, K. K., Weiss, L. M., & Huang, Q. (2008). Aberrant expression of CD7 in myeloblasts is highly associated with de novo acute myeloid leukemias with FLT3/ITD mutation. American Journal of Clinical Pathology, 129(4), 624-9. https://doi.org/10.1309/NRTX9AKXHR5JBT93
Rausei-Mills V, et al. Aberrant Expression of CD7 in Myeloblasts Is Highly Associated With De Novo Acute Myeloid Leukemias With FLT3/ITD Mutation. Am J Clin Pathol. 2008;129(4):624-9. PubMed PMID: 18343790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aberrant expression of CD7 in myeloblasts is highly associated with de novo acute myeloid leukemias with FLT3/ITD mutation. AU - Rausei-Mills,Veronica, AU - Chang,Karen L, AU - Gaal,Karl K, AU - Weiss,Lawrence M, AU - Huang,Qin, PY - 2008/3/18/pubmed PY - 2008/5/7/medline PY - 2008/3/18/entrez SP - 624 EP - 9 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 129 IS - 4 N2 - Acute myeloid leukemia (AML) with normal cytogenetics represents approximately 40% to 50% of de novo AML. This heterogeneous AML subgroup constitutes the single largest cytogenetic group with an intermediate prognosis. Previous studies have suggested that the Fms-like tyrosine kinase-3 internal tandem duplication (FLT3/ITD) mutation-positive de novo AML may represent a distinctive subgroup of AML. We analyzed the clinical and pathologic features of 15 cases of de novo AML with normal cytogenetics and with the FLT3/ITD mutation. In comparison with patients with AML without the FLT3/ITD mutation, patients with FLT3/ITD+ AML are relatively younger, more often have marked peripheral leukocytosis with a higher number of circulating blasts at initial examination, more often have minimal differentiation morphologic features, more frequently have abnormal CD7 coexpression, and have poorer outcome. Close association of aberrant CD7 expression and FLT3/ITD mutation in the myeloblasts of FLT3/ITD+ AML suggests that FLT3/ITD- mediated leukemic transformation occurs in the more early stage of myeloid progenitor cells. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/18343790/Aberrant_expression_of_CD7_in_myeloblasts_is_highly_associated_with_de_novo_acute_myeloid_leukemias_with_FLT3/ITD_mutation_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1309/NRTX9AKXHR5JBT93 DB - PRIME DP - Unbound Medicine ER -