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Lafutidine facilitates calcitonin gene-related peptide (CGRP) nerve-mediated vasodilation via vanilloid-1 receptors in rat mesenteric resistance arteries.
J Pharmacol Sci. 2008 Mar; 106(3):505-11.JP

Abstract

Lafutidine is a histamine H(2)-receptor antagonist with gastric antisecretory and gastroprotective activity associated with activation of capsaicin-sensitive nerves. The present study examined the effect of lafutidine on neurotransmission of capsaicin-sensitive calcitonin gene-related peptide (CGRP)-containing vasodilator nerves (CGRPergic nerves) in rat mesenteric resistance arteries. Rat mesenteric vascular beds were perfused with Krebs solution and vascular endothelium was removed by 30-s perfusion with sodium deoxycholate. In preparations preconstricted by continuous perfusion of methoxamine (alpha(1) adrenoceptor agonist), perfusion of lafutidine (0.1 - 10 microM) concentration-dependently augmented vasodilation induced by the periarterial nerve stimulation (PNS, 1 Hz) without affecting vasodilation induced by exogenous CGRP (10 pmol) injection. Perfusion of famotidine (H(2)-receptor antagonist, 1 - 100 microM) had no effect on either PNS-induced or CGRP-induced vasodilation. Perfusion of lafutidine concentration-dependently augmented vasodilation induced by a bolus injection of capsaicin (vanilloid-1 receptor agonist, 30 pmol). The presence of a vanilloid-1 receptor antagonist, ruthenium red (10 microM) or capsazepine (5 microM), abolished capsaicin-induced vasodilation and significantly decreased the PNS-induced vasodilation. The decreased PNS-induced vasodilation by ruthenium red or capsazepine was not affected by perfusion of lafutidine. These results suggest that lafutidine facilitates CGRP nerve-mediated vasodilation by modulating the function of presynaptic vanilloid-1 receptors located in CGRPergic nerves.

Authors+Show Affiliations

Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18344609

Citation

Sugiyama, Tetsuhiro, et al. "Lafutidine Facilitates Calcitonin Gene-related Peptide (CGRP) Nerve-mediated Vasodilation Via Vanilloid-1 Receptors in Rat Mesenteric Resistance Arteries." Journal of Pharmacological Sciences, vol. 106, no. 3, 2008, pp. 505-11.
Sugiyama T, Hatanaka Y, Iwatani Y, et al. Lafutidine facilitates calcitonin gene-related peptide (CGRP) nerve-mediated vasodilation via vanilloid-1 receptors in rat mesenteric resistance arteries. J Pharmacol Sci. 2008;106(3):505-11.
Sugiyama, T., Hatanaka, Y., Iwatani, Y., Jin, X., & Kawasaki, H. (2008). Lafutidine facilitates calcitonin gene-related peptide (CGRP) nerve-mediated vasodilation via vanilloid-1 receptors in rat mesenteric resistance arteries. Journal of Pharmacological Sciences, 106(3), 505-11.
Sugiyama T, et al. Lafutidine Facilitates Calcitonin Gene-related Peptide (CGRP) Nerve-mediated Vasodilation Via Vanilloid-1 Receptors in Rat Mesenteric Resistance Arteries. J Pharmacol Sci. 2008;106(3):505-11. PubMed PMID: 18344609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lafutidine facilitates calcitonin gene-related peptide (CGRP) nerve-mediated vasodilation via vanilloid-1 receptors in rat mesenteric resistance arteries. AU - Sugiyama,Tetsuhiro, AU - Hatanaka,Yukako, AU - Iwatani,Yukiko, AU - Jin,Xin, AU - Kawasaki,Hiromu, Y1 - 2008/03/12/ PY - 2008/3/18/pubmed PY - 2008/5/2/medline PY - 2008/3/18/entrez SP - 505 EP - 11 JF - Journal of pharmacological sciences JO - J Pharmacol Sci VL - 106 IS - 3 N2 - Lafutidine is a histamine H(2)-receptor antagonist with gastric antisecretory and gastroprotective activity associated with activation of capsaicin-sensitive nerves. The present study examined the effect of lafutidine on neurotransmission of capsaicin-sensitive calcitonin gene-related peptide (CGRP)-containing vasodilator nerves (CGRPergic nerves) in rat mesenteric resistance arteries. Rat mesenteric vascular beds were perfused with Krebs solution and vascular endothelium was removed by 30-s perfusion with sodium deoxycholate. In preparations preconstricted by continuous perfusion of methoxamine (alpha(1) adrenoceptor agonist), perfusion of lafutidine (0.1 - 10 microM) concentration-dependently augmented vasodilation induced by the periarterial nerve stimulation (PNS, 1 Hz) without affecting vasodilation induced by exogenous CGRP (10 pmol) injection. Perfusion of famotidine (H(2)-receptor antagonist, 1 - 100 microM) had no effect on either PNS-induced or CGRP-induced vasodilation. Perfusion of lafutidine concentration-dependently augmented vasodilation induced by a bolus injection of capsaicin (vanilloid-1 receptor agonist, 30 pmol). The presence of a vanilloid-1 receptor antagonist, ruthenium red (10 microM) or capsazepine (5 microM), abolished capsaicin-induced vasodilation and significantly decreased the PNS-induced vasodilation. The decreased PNS-induced vasodilation by ruthenium red or capsazepine was not affected by perfusion of lafutidine. These results suggest that lafutidine facilitates CGRP nerve-mediated vasodilation by modulating the function of presynaptic vanilloid-1 receptors located in CGRPergic nerves. SN - 1347-8613 UR - https://www.unboundmedicine.com/medline/citation/18344609/Lafutidine_facilitates_calcitonin_gene_related_peptide__CGRP__nerve_mediated_vasodilation_via_vanilloid_1_receptors_in_rat_mesenteric_resistance_arteries_ L2 - https://linkinghub.elsevier.com/retrieve/pii/JST.JSTAGE/jphs/FP0072259 DB - PRIME DP - Unbound Medicine ER -