Tags

Type your tag names separated by a space and hit enter

Vibrotactile sense in median and ulnar nerve innervated fingers of men with Type 2 diabetes, normal or impaired glucose tolerance.
Diabet Med. 2008 May; 25(5):543-9.DM

Abstract

AIMS

To investigate vibrotactile sense (large fibre neuropathy) at different frequencies in index and little fingers (median and ulnar nerves, respectively) of subjects with diabetes, or impaired (IGT) or normal glucose tolerance (NGT).

METHODS

Vibration thresholds (tactilometry at seven frequencies (8, 16, 32, 64, 125, 250 and 500 Hz)) and median nerve function (electrophysiology) were examined in men (age 73.4 +/- 0.12 years; n = 58, mean +/- sd) with persistent NGT (n = 28) or IGT (n = 7) or with Type 2 diabetes mellitus (T2DM) (n = 23) for > 15 years.

RESULTS

HbA1c was increased and vibrotactile sense (sensibility index) was impaired in index and little fingers in men with T2DM. Vibration thresholds were particularly increased at 16, 250 and 500 Hz in the little finger (ulnar nerve). T2DM subjects showed electrophysiological (gold standard) signs of neuropathy in the median nerve. Although subjects with persistent IGT had higher HbA1c, vibrotactile sensation and electrophysiology remained normal. HbA1c did not correlate with vibrotactile sense or electrophysiology, but the latter two correlated with respect to Z-score (sign of neuropathy) in forearm (NGT) and at wrist level (NGT and DM).

CONCLUSIONS

Vibration thresholds are increased in the finger pulps in T2DM subjects, particularly at specific frequencies in ulnar nerve innervated finger pulps. Neuropathy is not present in IGT. Tactilometry, with a multi-frequency approach, is a sensitive technique to screen for large fibre neuropathy in T2DM. Frequency-related changes may mirror dysfunction of various receptors.

Authors+Show Affiliations

Department of CLinical Sciences in Malmö (Hand Surgery), Malmö University Hospital, Lund University, Malmö, Sweden. lars.dahlin@med.lu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18346156

Citation

Dahlin, L B., et al. "Vibrotactile Sense in Median and Ulnar Nerve Innervated Fingers of Men With Type 2 Diabetes, Normal or Impaired Glucose Tolerance." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 25, no. 5, 2008, pp. 543-9.
Dahlin LB, Thrainsdottir S, Cederlund R, et al. Vibrotactile sense in median and ulnar nerve innervated fingers of men with Type 2 diabetes, normal or impaired glucose tolerance. Diabet Med. 2008;25(5):543-9.
Dahlin, L. B., Thrainsdottir, S., Cederlund, R., Thomsen, N. O., Eriksson, K. F., Rosén, I., Speidel, T., & Sundqvist, G. (2008). Vibrotactile sense in median and ulnar nerve innervated fingers of men with Type 2 diabetes, normal or impaired glucose tolerance. Diabetic Medicine : a Journal of the British Diabetic Association, 25(5), 543-9. https://doi.org/10.1111/j.1464-5491.2008.02433.x
Dahlin LB, et al. Vibrotactile Sense in Median and Ulnar Nerve Innervated Fingers of Men With Type 2 Diabetes, Normal or Impaired Glucose Tolerance. Diabet Med. 2008;25(5):543-9. PubMed PMID: 18346156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vibrotactile sense in median and ulnar nerve innervated fingers of men with Type 2 diabetes, normal or impaired glucose tolerance. AU - Dahlin,L B, AU - Thrainsdottir,S, AU - Cederlund,R, AU - Thomsen,N O B, AU - Eriksson,K F, AU - Rosén,I, AU - Speidel,T, AU - Sundqvist,G, Y1 - 2008/03/13/ PY - 2008/3/19/pubmed PY - 2008/8/2/medline PY - 2008/3/19/entrez SP - 543 EP - 9 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 25 IS - 5 N2 - AIMS: To investigate vibrotactile sense (large fibre neuropathy) at different frequencies in index and little fingers (median and ulnar nerves, respectively) of subjects with diabetes, or impaired (IGT) or normal glucose tolerance (NGT). METHODS: Vibration thresholds (tactilometry at seven frequencies (8, 16, 32, 64, 125, 250 and 500 Hz)) and median nerve function (electrophysiology) were examined in men (age 73.4 +/- 0.12 years; n = 58, mean +/- sd) with persistent NGT (n = 28) or IGT (n = 7) or with Type 2 diabetes mellitus (T2DM) (n = 23) for > 15 years. RESULTS: HbA1c was increased and vibrotactile sense (sensibility index) was impaired in index and little fingers in men with T2DM. Vibration thresholds were particularly increased at 16, 250 and 500 Hz in the little finger (ulnar nerve). T2DM subjects showed electrophysiological (gold standard) signs of neuropathy in the median nerve. Although subjects with persistent IGT had higher HbA1c, vibrotactile sensation and electrophysiology remained normal. HbA1c did not correlate with vibrotactile sense or electrophysiology, but the latter two correlated with respect to Z-score (sign of neuropathy) in forearm (NGT) and at wrist level (NGT and DM). CONCLUSIONS: Vibration thresholds are increased in the finger pulps in T2DM subjects, particularly at specific frequencies in ulnar nerve innervated finger pulps. Neuropathy is not present in IGT. Tactilometry, with a multi-frequency approach, is a sensitive technique to screen for large fibre neuropathy in T2DM. Frequency-related changes may mirror dysfunction of various receptors. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/18346156/Vibrotactile_sense_in_median_and_ulnar_nerve_innervated_fingers_of_men_with_Type_2_diabetes_normal_or_impaired_glucose_tolerance_ L2 - https://doi.org/10.1111/j.1464-5491.2008.02433.x DB - PRIME DP - Unbound Medicine ER -