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Endothelin-1 levels and albuminuria in patients with type 2 diabetes mellitus.
Diabetes Res Clin Pract. 2008 May; 80(2):299-304.DR

Abstract

AIM

To evaluate the relationship of plasma endothelin-1 (ET-1) levels, a marker of endothelial dysfunction, and urinary albumin excretion in patients with type 2 diabetes mellitus (DM).

METHODS

Cross-sectional study was conducted in 279 patients (132 males, mean age: 58.7+/-11.0 years, mean DM duration: 11.3+/-8.1 years). Urinary albumin excretion, ET-1, and insulin were measured. Insulin sensitivity was estimated by homeostasis model assessment (HOMA-ir) index.

RESULTS

ET-1 was associated with urinary albumin excretion after controlling for age, gender, body mass index, blood pressure, HbA1c test, and total cholesterol (R=0.436; adjusted R(2)=0.190, P<0.01). Furthermore, there was a progressive increase in plasma ET-1 levels from patients with normoalbuminuria (n=187, 0.92+/-0.50pg/ml), microalbuminuria (n=68, 1.13+/-0.52pg/ml) to macroalbuminuria (n=24, 1.93+/-1.10pg/ml, P<0.01).

CONCLUSION

There is an independent association of plasma ET-1 levels with urinary albumin excretion. In addition, plasma ET-1 levels started to increase in the normal values of urinary albumin excretion suggesting that in patients with type 2 DM endothelial dysfunction is already present, in urinary albumin excretion values considered normal.

Authors+Show Affiliations

Endocrine Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18346810

Citation

Zanatta, Claudete M., et al. "Endothelin-1 Levels and Albuminuria in Patients With Type 2 Diabetes Mellitus." Diabetes Research and Clinical Practice, vol. 80, no. 2, 2008, pp. 299-304.
Zanatta CM, Gerchman F, Burttet L, et al. Endothelin-1 levels and albuminuria in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2008;80(2):299-304.
Zanatta, C. M., Gerchman, F., Burttet, L., Nabinger, G., Jacques-Silva, M. C., Canani, L. H., & Gross, J. L. (2008). Endothelin-1 levels and albuminuria in patients with type 2 diabetes mellitus. Diabetes Research and Clinical Practice, 80(2), 299-304. https://doi.org/10.1016/j.diabres.2007.12.024
Zanatta CM, et al. Endothelin-1 Levels and Albuminuria in Patients With Type 2 Diabetes Mellitus. Diabetes Res Clin Pract. 2008;80(2):299-304. PubMed PMID: 18346810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endothelin-1 levels and albuminuria in patients with type 2 diabetes mellitus. AU - Zanatta,Claudete M, AU - Gerchman,Fernando, AU - Burttet,Lucas, AU - Nabinger,Gustavo, AU - Jacques-Silva,Maria C, AU - Canani,Luís H, AU - Gross,Jorge L, Y1 - 2008/03/17/ PY - 2007/07/28/received PY - 2007/12/26/accepted PY - 2008/3/19/pubmed PY - 2008/8/7/medline PY - 2008/3/19/entrez SP - 299 EP - 304 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 80 IS - 2 N2 - AIM: To evaluate the relationship of plasma endothelin-1 (ET-1) levels, a marker of endothelial dysfunction, and urinary albumin excretion in patients with type 2 diabetes mellitus (DM). METHODS: Cross-sectional study was conducted in 279 patients (132 males, mean age: 58.7+/-11.0 years, mean DM duration: 11.3+/-8.1 years). Urinary albumin excretion, ET-1, and insulin were measured. Insulin sensitivity was estimated by homeostasis model assessment (HOMA-ir) index. RESULTS: ET-1 was associated with urinary albumin excretion after controlling for age, gender, body mass index, blood pressure, HbA1c test, and total cholesterol (R=0.436; adjusted R(2)=0.190, P<0.01). Furthermore, there was a progressive increase in plasma ET-1 levels from patients with normoalbuminuria (n=187, 0.92+/-0.50pg/ml), microalbuminuria (n=68, 1.13+/-0.52pg/ml) to macroalbuminuria (n=24, 1.93+/-1.10pg/ml, P<0.01). CONCLUSION: There is an independent association of plasma ET-1 levels with urinary albumin excretion. In addition, plasma ET-1 levels started to increase in the normal values of urinary albumin excretion suggesting that in patients with type 2 DM endothelial dysfunction is already present, in urinary albumin excretion values considered normal. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/18346810/Endothelin_1_levels_and_albuminuria_in_patients_with_type_2_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(08)00006-5 DB - PRIME DP - Unbound Medicine ER -