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Validation of a graded response questionnaire for the diagnosis of gastroesophageal reflux disease in an Asian primary care population.
J Clin Gastroenterol. 2008 Jul; 42(6):680-6.JC

Abstract

BACKGROUND

Diagnosis of gastroesophageal reflux disease (GERD) based on subjective evaluation of symptoms alone is challenging.

GOALS

To test the validity and reliability of a graded response questionnaire to identify patients with GERD.

STUDY

Patients presenting with upper abdominal symptoms for more than a month, and without alarm features were consecutively recruited. They completed a 12-item questionnaire encompassing 6 symptoms presented either in Chinese or English language. Scores were analyzed for validity in diagnosis of GERD, using gastroenterologist's diagnosis as reference standard. Receiver operating characteristic (ROC) analysis, predictive values, likelihood ratios, and diagnostic odds ratio were used to evaluate diagnostic accuracy.

RESULTS

Of 209 patients studied, 163 (78%) answered the English whereas 45 (21.5%) answered the Chinese version. At a cut-off of > or =28.5 in total symptom scores, the Chinese version had a sensitivity of 87.5% and specificity of 75.7% with an area under the ROC curve (AUCROC) of 0.824 for diagnosis of GERD. Corresponding sensitivity and specificity for the English version were 76.9% and 50.8%, respectively, with an AUCROC of 0.760. Positive predictive value, negative predictive value, positive likelihood ratio (+LR), negative likelihood ratio (-LR), and diagnostic odds ratio were 0.438, 0.966, 3.597, 0.165, and 21.778 and 0.330, 0.875, 1.564, 0.454, and 3.443 for the Chinese and English versions, respectively.

CONCLUSIONS

The questionnaires demonstrated good construct reliability, which were highly sensitive and reasonably specific for the detection of GERD. They are useful tools to help primary care physicians in identifying GERD in patients presenting with uninvestigated upper abdominal symptoms.

Authors+Show Affiliations

Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Validation Study

Language

eng

PubMed ID

18347510

Citation

Ho, Khek Yu, et al. "Validation of a Graded Response Questionnaire for the Diagnosis of Gastroesophageal Reflux Disease in an Asian Primary Care Population." Journal of Clinical Gastroenterology, vol. 42, no. 6, 2008, pp. 680-6.
Ho KY, Gwee KA, Khor JL, et al. Validation of a graded response questionnaire for the diagnosis of gastroesophageal reflux disease in an Asian primary care population. J Clin Gastroenterol. 2008;42(6):680-6.
Ho, K. Y., Gwee, K. A., Khor, J. L., Selamat, D. S., & Yeoh, K. G. (2008). Validation of a graded response questionnaire for the diagnosis of gastroesophageal reflux disease in an Asian primary care population. Journal of Clinical Gastroenterology, 42(6), 680-6. https://doi.org/10.1097/MCG.0b013e3180653613
Ho KY, et al. Validation of a Graded Response Questionnaire for the Diagnosis of Gastroesophageal Reflux Disease in an Asian Primary Care Population. J Clin Gastroenterol. 2008;42(6):680-6. PubMed PMID: 18347510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Validation of a graded response questionnaire for the diagnosis of gastroesophageal reflux disease in an Asian primary care population. AU - Ho,Khek Yu, AU - Gwee,Kok Ann, AU - Khor,Jen Lock, AU - Selamat,Dede Sutedja, AU - Yeoh,Khay Guan, PY - 2008/3/19/pubmed PY - 2008/10/8/medline PY - 2008/3/19/entrez SP - 680 EP - 6 JF - Journal of clinical gastroenterology JO - J. Clin. Gastroenterol. VL - 42 IS - 6 N2 - BACKGROUND: Diagnosis of gastroesophageal reflux disease (GERD) based on subjective evaluation of symptoms alone is challenging. GOALS: To test the validity and reliability of a graded response questionnaire to identify patients with GERD. STUDY: Patients presenting with upper abdominal symptoms for more than a month, and without alarm features were consecutively recruited. They completed a 12-item questionnaire encompassing 6 symptoms presented either in Chinese or English language. Scores were analyzed for validity in diagnosis of GERD, using gastroenterologist's diagnosis as reference standard. Receiver operating characteristic (ROC) analysis, predictive values, likelihood ratios, and diagnostic odds ratio were used to evaluate diagnostic accuracy. RESULTS: Of 209 patients studied, 163 (78%) answered the English whereas 45 (21.5%) answered the Chinese version. At a cut-off of > or =28.5 in total symptom scores, the Chinese version had a sensitivity of 87.5% and specificity of 75.7% with an area under the ROC curve (AUCROC) of 0.824 for diagnosis of GERD. Corresponding sensitivity and specificity for the English version were 76.9% and 50.8%, respectively, with an AUCROC of 0.760. Positive predictive value, negative predictive value, positive likelihood ratio (+LR), negative likelihood ratio (-LR), and diagnostic odds ratio were 0.438, 0.966, 3.597, 0.165, and 21.778 and 0.330, 0.875, 1.564, 0.454, and 3.443 for the Chinese and English versions, respectively. CONCLUSIONS: The questionnaires demonstrated good construct reliability, which were highly sensitive and reasonably specific for the detection of GERD. They are useful tools to help primary care physicians in identifying GERD in patients presenting with uninvestigated upper abdominal symptoms. SN - 1539-2031 UR - https://www.unboundmedicine.com/medline/citation/18347510/Validation_of_a_graded_response_questionnaire_for_the_diagnosis_of_gastroesophageal_reflux_disease_in_an_Asian_primary_care_population_ L2 - http://dx.doi.org/10.1097/MCG.0b013e3180653613 DB - PRIME DP - Unbound Medicine ER -