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Association of the 163A/G and 1181G/C osteoprotegerin polymorphism with bone mineral density.
Horm Metab Res. 2008 Mar; 40(3):219-24.HM

Abstract

The aim of the study was to investigate the distribution of 163 A/G osteoprotegerin gene promoter and 1181 G/C osteoprotegerin exon 1 polymorphisms in a group of women with different hormonal status and to analyze their relationship with BMD. Osteoprotegerin polymorphisms and BMD were analyzed in 332 women (69 premenopausal and 263 postmenopausal). BMD was quantified at the lumbar spine (L 2-4), femoral neck, and total hip. Genotyping for the presence of different polymorphisms was performed using the Custom Taqman ((R)) SNP Genotyping assays. There were not significant differences in BMD according to 163 A/G genotype. However, significant differences in lumbar spine BMD were found according to 1181 G/C alleles. Thus, women with CC genotype had significant higher BMD at the lumbar spine than those with GC or GG genotype. No differences were found in femoral neck and total hip BMD. In age-adjusted models, the 1181 G/C OPG polymorphism explained 2.2% of BMD variance at the spine, 0.3% at the femoral neck, and 0.9% at the total hip in the whole group. In the subgroup of premenopausal women, the polymorphism was strongly related to spine BMD, and explained 11.5% of the variance, whereas body weight explained 7.9%. The 1181 G/C polymorphism was associated with lumbar spine BMD in Spanish women. Premenopausal women with the CC genotype had a higher BMD.

Authors+Show Affiliations

Clinical Biochemistry, Hospital Universitario Marqués de Valdecilla, University of Cantabria, Santander, Spain. mgunzueta@humv.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18348083

Citation

García-Unzueta, M T., et al. "Association of the 163A/G and 1181G/C Osteoprotegerin Polymorphism With Bone Mineral Density." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 40, no. 3, 2008, pp. 219-24.
García-Unzueta MT, Riancho JA, Zarrabeitia MT, et al. Association of the 163A/G and 1181G/C osteoprotegerin polymorphism with bone mineral density. Horm Metab Res. 2008;40(3):219-24.
García-Unzueta, M. T., Riancho, J. A., Zarrabeitia, M. T., Sañudo, C., Berja, A., Valero, C., Pesquera, C., Paule, B., González-Macías, J., & Amado, J. A. (2008). Association of the 163A/G and 1181G/C osteoprotegerin polymorphism with bone mineral density. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 40(3), 219-24. https://doi.org/10.1055/s-2008-1046793
García-Unzueta MT, et al. Association of the 163A/G and 1181G/C Osteoprotegerin Polymorphism With Bone Mineral Density. Horm Metab Res. 2008;40(3):219-24. PubMed PMID: 18348083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of the 163A/G and 1181G/C osteoprotegerin polymorphism with bone mineral density. AU - García-Unzueta,M T, AU - Riancho,J A, AU - Zarrabeitia,M T, AU - Sañudo,C, AU - Berja,A, AU - Valero,C, AU - Pesquera,C, AU - Paule,B, AU - González-Macías,J, AU - Amado,J A, PY - 2008/3/19/pubmed PY - 2008/5/14/medline PY - 2008/3/19/entrez SP - 219 EP - 24 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 40 IS - 3 N2 - The aim of the study was to investigate the distribution of 163 A/G osteoprotegerin gene promoter and 1181 G/C osteoprotegerin exon 1 polymorphisms in a group of women with different hormonal status and to analyze their relationship with BMD. Osteoprotegerin polymorphisms and BMD were analyzed in 332 women (69 premenopausal and 263 postmenopausal). BMD was quantified at the lumbar spine (L 2-4), femoral neck, and total hip. Genotyping for the presence of different polymorphisms was performed using the Custom Taqman ((R)) SNP Genotyping assays. There were not significant differences in BMD according to 163 A/G genotype. However, significant differences in lumbar spine BMD were found according to 1181 G/C alleles. Thus, women with CC genotype had significant higher BMD at the lumbar spine than those with GC or GG genotype. No differences were found in femoral neck and total hip BMD. In age-adjusted models, the 1181 G/C OPG polymorphism explained 2.2% of BMD variance at the spine, 0.3% at the femoral neck, and 0.9% at the total hip in the whole group. In the subgroup of premenopausal women, the polymorphism was strongly related to spine BMD, and explained 11.5% of the variance, whereas body weight explained 7.9%. The 1181 G/C polymorphism was associated with lumbar spine BMD in Spanish women. Premenopausal women with the CC genotype had a higher BMD. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/18348083/Association_of_the_163A/G_and_1181G/C_osteoprotegerin_polymorphism_with_bone_mineral_density_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2008-1046793 DB - PRIME DP - Unbound Medicine ER -