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Prognostic factors for high-risk early-stage epithelial ovarian cancer: a Gynecologic Oncology Group study.
Cancer. 2008 May 15; 112(10):2202-10.C

Abstract

BACKGROUND

The purpose was to identify the factors predictive of recurrence and survival in patients with high-risk (stage I, grade 3; stage IC, stage II, or clear cell) epithelial ovarian cancer after adjuvant therapy.

METHODS

Data was extracted from patients who underwent primary surgery followed by adjuvant therapy in 2 randomized trials by the Gynecologic Oncology Group (Protocols 95 and 157). Kaplan-Meier survival estimates and Cox proportional hazards model adjusted for covariates were used for analyses.

RESULTS

Of 506 patients (median age = 56.2 years), 347 (68.6%) had stage I and 159 (31.4%) had stage II cancers. The 5-year recurrence-free (RFS) and overall survivals (OS) were 75.5% and 81.7%, respectively. On multivariate analysis, older age, higher stage, higher grade, and malignant cytology were independent prognostic factors predictive for recurrence and poorer survival. The risk of recurrence was higher for those >/=60 versus < 60 years (hazards ratio [HR] = 1.57, 95% confidence interval [CI], 1.12-2.19), stage II (stage II: HR = 2.70, 95% CI, 1.41-5.16) versus stage IA or IB, grade 2 (HR = 1.84, 95% CI, 1.04-3.27) and grade 3 (HR = 2.47, 95% CI, 1.39-4.37) versus grade 1, and positive versus negative cytology (HR = 1.72, 95% CI, 1.21-2.45). By using these factors in a prognostic index, those with low-risk (no or 1 risk factor), intermediate-risk (2 factors), and high-risk (3-4 risk factors) disease had survivals of 88%, 82%, and 75%, respectively (P < .05).

CONCLUSIONS

Age, stage, grade, and cytology are important prognostic factors in high-risk early-stage epithelial ovarian cancer. This information may be used in the design of future clinical trials.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Chan JK
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco School of Medicine, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California 94143-1702, USA. chanjohn@obgyn.ucsf.edu
Tian C
No affiliation info available
Monk BJ
No affiliation info available
Herzog T
No affiliation info available
Kapp DS
No affiliation info available
Bell J
No affiliation info available
Young RC
No affiliation info available
Gynecologic Oncology Group
No affiliation info available

MeSH

Adenocarcinoma, Clear CellAdenocarcinoma, MucinousAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, EndometrioidCystadenocarcinoma, SerousFemaleFollow-Up StudiesHumansMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingNeoplasms, Glandular and EpithelialOvarian NeoplasmsPrognosisRisk FactorsSurvival Rate

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18348296

Citation

Chan, John K., et al. "Prognostic Factors for High-risk Early-stage Epithelial Ovarian Cancer: a Gynecologic Oncology Group Study." Cancer, vol. 112, no. 10, 2008, pp. 2202-10.
Chan JK, Tian C, Monk BJ, et al. Prognostic factors for high-risk early-stage epithelial ovarian cancer: a Gynecologic Oncology Group study. Cancer. 2008;112(10):2202-10.
Chan, J. K., Tian, C., Monk, B. J., Herzog, T., Kapp, D. S., Bell, J., & Young, R. C. (2008). Prognostic factors for high-risk early-stage epithelial ovarian cancer: a Gynecologic Oncology Group study. Cancer, 112(10), 2202-10. https://doi.org/10.1002/cncr.23390
Chan JK, et al. Prognostic Factors for High-risk Early-stage Epithelial Ovarian Cancer: a Gynecologic Oncology Group Study. Cancer. 2008 May 15;112(10):2202-10. PubMed PMID: 18348296.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic factors for high-risk early-stage epithelial ovarian cancer: a Gynecologic Oncology Group study. AU - Chan,John K, AU - Tian,Chunqiao, AU - Monk,Bradley J, AU - Herzog,Thomas, AU - Kapp,Daniel S, AU - Bell,Jeffrey, AU - Young,Robert C, AU - ,, PY - 2008/3/19/pubmed PY - 2008/6/5/medline PY - 2008/3/19/entrez SP - 2202 EP - 10 JF - Cancer JO - Cancer VL - 112 IS - 10 N2 - BACKGROUND: The purpose was to identify the factors predictive of recurrence and survival in patients with high-risk (stage I, grade 3; stage IC, stage II, or clear cell) epithelial ovarian cancer after adjuvant therapy. METHODS: Data was extracted from patients who underwent primary surgery followed by adjuvant therapy in 2 randomized trials by the Gynecologic Oncology Group (Protocols 95 and 157). Kaplan-Meier survival estimates and Cox proportional hazards model adjusted for covariates were used for analyses. RESULTS: Of 506 patients (median age = 56.2 years), 347 (68.6%) had stage I and 159 (31.4%) had stage II cancers. The 5-year recurrence-free (RFS) and overall survivals (OS) were 75.5% and 81.7%, respectively. On multivariate analysis, older age, higher stage, higher grade, and malignant cytology were independent prognostic factors predictive for recurrence and poorer survival. The risk of recurrence was higher for those >/=60 versus < 60 years (hazards ratio [HR] = 1.57, 95% confidence interval [CI], 1.12-2.19), stage II (stage II: HR = 2.70, 95% CI, 1.41-5.16) versus stage IA or IB, grade 2 (HR = 1.84, 95% CI, 1.04-3.27) and grade 3 (HR = 2.47, 95% CI, 1.39-4.37) versus grade 1, and positive versus negative cytology (HR = 1.72, 95% CI, 1.21-2.45). By using these factors in a prognostic index, those with low-risk (no or 1 risk factor), intermediate-risk (2 factors), and high-risk (3-4 risk factors) disease had survivals of 88%, 82%, and 75%, respectively (P < .05). CONCLUSIONS: Age, stage, grade, and cytology are important prognostic factors in high-risk early-stage epithelial ovarian cancer. This information may be used in the design of future clinical trials. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/18348296/Prognostic_factors_for_high_risk_early_stage_epithelial_ovarian_cancer:_a_Gynecologic_Oncology_Group_study_ DB - PRIME DP - Unbound Medicine ER -