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Sun exposure and cancer survival in Norway: changes in the risk of death with season of diagnosis and latitude.
Adv Exp Med Biol. 2008; 624:43-54.AE

Abstract

Epidemiological and experimental studies suggest that derivatives of vitamin D may improve prognosis of a number of cancer types. Sun is our most important source of vitamin D. Seasonal variations and latitudinal gradients of calcidiol (the marker of vitamin D status) have been reported. We wanted to investigate if season and latitude play any role for survival from seven different cancer types in Norway. Seasonal and geographical variations of vitamin D were estimated by calculations and were compared with clinical data. For the survival analyses, 249373 cancer patients were followed for three years after diagnosis and the risk of death was analyzed separately for summer- and winter diagnosis, as well as for two geographical regions with different UV exposures. We found a 15-25% better survival for patients diagnosed during summer and a slight beneficial effect for residents of the high UV region for some of the cancer forms investigated. Based on our results we suggest that calcidiol concentration at the time of cancer diagnosis is related to survival and discuss briefly ways to improve the vitamin D levels in the general population.

Authors+Show Affiliations

Deparment of Radiation Biology, Institute for Cancer Research, Montebello, Oslo, Norway. a.c.porojnicu@usit.uio.noNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18348446

Citation

Porojnicu, Alina Carmen, et al. "Sun Exposure and Cancer Survival in Norway: Changes in the Risk of Death With Season of Diagnosis and Latitude." Advances in Experimental Medicine and Biology, vol. 624, 2008, pp. 43-54.
Porojnicu AC, Dahlback A, Moan J. Sun exposure and cancer survival in Norway: changes in the risk of death with season of diagnosis and latitude. Adv Exp Med Biol. 2008;624:43-54.
Porojnicu, A. C., Dahlback, A., & Moan, J. (2008). Sun exposure and cancer survival in Norway: changes in the risk of death with season of diagnosis and latitude. Advances in Experimental Medicine and Biology, 624, 43-54. https://doi.org/10.1007/978-0-387-77574-6_4
Porojnicu AC, Dahlback A, Moan J. Sun Exposure and Cancer Survival in Norway: Changes in the Risk of Death With Season of Diagnosis and Latitude. Adv Exp Med Biol. 2008;624:43-54. PubMed PMID: 18348446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sun exposure and cancer survival in Norway: changes in the risk of death with season of diagnosis and latitude. AU - Porojnicu,Alina Carmen, AU - Dahlback,Arne, AU - Moan,Johan, PY - 2008/3/20/pubmed PY - 2008/4/30/medline PY - 2008/3/20/entrez SP - 43 EP - 54 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 624 N2 - Epidemiological and experimental studies suggest that derivatives of vitamin D may improve prognosis of a number of cancer types. Sun is our most important source of vitamin D. Seasonal variations and latitudinal gradients of calcidiol (the marker of vitamin D status) have been reported. We wanted to investigate if season and latitude play any role for survival from seven different cancer types in Norway. Seasonal and geographical variations of vitamin D were estimated by calculations and were compared with clinical data. For the survival analyses, 249373 cancer patients were followed for three years after diagnosis and the risk of death was analyzed separately for summer- and winter diagnosis, as well as for two geographical regions with different UV exposures. We found a 15-25% better survival for patients diagnosed during summer and a slight beneficial effect for residents of the high UV region for some of the cancer forms investigated. Based on our results we suggest that calcidiol concentration at the time of cancer diagnosis is related to survival and discuss briefly ways to improve the vitamin D levels in the general population. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/18348446/Sun_exposure_and_cancer_survival_in_Norway:_changes_in_the_risk_of_death_with_season_of_diagnosis_and_latitude_ L2 - https://dx.doi.org/10.1007/978-0-387-77574-6_4 DB - PRIME DP - Unbound Medicine ER -