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The relationship between bispectral index and propofol during target-controlled infusion anesthesia: a comparative study between children and young adults.
Anesth Analg. 2008 Apr; 106(4):1109-16, table of contents.A&A

Abstract

BACKGROUND

In this prospective study, we compared the relationship between propofol concentrations and bispectral index (BIS) in children versus young adults anesthetized with target-controlled infusion (TCI) of propofol.

METHODS

Forty-five prepubertal subjects (children) and 45 postpubertal subjects (adults) were studied. All patients were anesthetized with TCI of propofol, based on the Kataria et al.'s model for children and on the Schnider et al.'s model for adults. All data from the BIS and the TCI system were continuously recorded using Rugloop software. Remifentanil was continuously administered throughout the study (0.25 microg x kg(-1) x min(-1)). In all patients, after the end of surgery, a 12-min period with a stable target plasma concentration (Ct) of propofol, randomly assigned at 2, 3, 4, 5, and 6 microg/mL, was performed. In addition, in most of the patients, another 12-min period was performed during which the BIS was targeted at 50 +/- 5. After each 12-min steady-state period, the Ct and BIS were noted and the plasma concentration of propofol was measured (Cm). The Ct and Cm corresponding to half maximal effect (BIS(50)) was determined by the Hill equation, and by targeting BIS at 50.

RESULTS

In children, as in adults, BIS values were highly correlated with the corresponding Ct or Cm of propofol following classical E(max) dose-response curves. The ECt(50) and the ECm(50), derived from the dose-response curves, were higher in children than in adults: ECm(50): 4.0 (3.6-4.5) microg/mL vs 3.3 (3.0-3.7) microg/mL [mean (95% CI)], P < 0.001; as well were the Ct and Cm clinically obtained when BIS was targeted at 50 (Cm(50): 4.3 +/- 1.1 microg/mL vs 3.4 +/- 1.2 microg/mL, (mean +/- SD) P < 0.05, children versus adults). Cm was generally under-estimated by the Ct, and the bias was higher in children than in adults: 2.6 +/- 2.6 microg/mL vs 1.7 +/- 1.6 microg/mL (P = 0.05).

CONCLUSIONS

The good relationship between propofol and BIS demonstrated in children as in adults suggested a slightly lower sensitivity to propofol in children. As the predictability of plasma propofol concentrations with the classical pharmacokinetic/pharmacodynamic models is limited in children, a cerebral pharmacodynamic feedback, such as BIS, may be useful in this population.

Authors+Show Affiliations

Service d'Anesthésie Pédiatrique, Hôpital Armand Trousseau, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18349180

Citation

Rigouzzo, Agnes, et al. "The Relationship Between Bispectral Index and Propofol During Target-controlled Infusion Anesthesia: a Comparative Study Between Children and Young Adults." Anesthesia and Analgesia, vol. 106, no. 4, 2008, 1109-16, table of contents.
Rigouzzo A, Girault L, Louvet N, et al. The relationship between bispectral index and propofol during target-controlled infusion anesthesia: a comparative study between children and young adults. Anesth Analg. 2008;106(4):1109-16, table of contents.
Rigouzzo, A., Girault, L., Louvet, N., Servin, F., De-Smet, T., Piat, V., Seeman, R., Murat, I., & Constant, I. (2008). The relationship between bispectral index and propofol during target-controlled infusion anesthesia: a comparative study between children and young adults. Anesthesia and Analgesia, 106(4), 1109-16, table of contents. https://doi.org/10.1213/ane.0b013e318164f388
Rigouzzo A, et al. The Relationship Between Bispectral Index and Propofol During Target-controlled Infusion Anesthesia: a Comparative Study Between Children and Young Adults. Anesth Analg. 2008;106(4):1109-16, table of contents. PubMed PMID: 18349180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between bispectral index and propofol during target-controlled infusion anesthesia: a comparative study between children and young adults. AU - Rigouzzo,Agnes, AU - Girault,Laure, AU - Louvet,Nicolas, AU - Servin,Frederique, AU - De-Smet,Tom, AU - Piat,Veronique, AU - Seeman,Robert, AU - Murat,Isabelle, AU - Constant,Isabelle, PY - 2008/3/20/pubmed PY - 2008/4/26/medline PY - 2008/3/20/entrez SP - 1109-16, table of contents JF - Anesthesia and analgesia JO - Anesth Analg VL - 106 IS - 4 N2 - BACKGROUND: In this prospective study, we compared the relationship between propofol concentrations and bispectral index (BIS) in children versus young adults anesthetized with target-controlled infusion (TCI) of propofol. METHODS: Forty-five prepubertal subjects (children) and 45 postpubertal subjects (adults) were studied. All patients were anesthetized with TCI of propofol, based on the Kataria et al.'s model for children and on the Schnider et al.'s model for adults. All data from the BIS and the TCI system were continuously recorded using Rugloop software. Remifentanil was continuously administered throughout the study (0.25 microg x kg(-1) x min(-1)). In all patients, after the end of surgery, a 12-min period with a stable target plasma concentration (Ct) of propofol, randomly assigned at 2, 3, 4, 5, and 6 microg/mL, was performed. In addition, in most of the patients, another 12-min period was performed during which the BIS was targeted at 50 +/- 5. After each 12-min steady-state period, the Ct and BIS were noted and the plasma concentration of propofol was measured (Cm). The Ct and Cm corresponding to half maximal effect (BIS(50)) was determined by the Hill equation, and by targeting BIS at 50. RESULTS: In children, as in adults, BIS values were highly correlated with the corresponding Ct or Cm of propofol following classical E(max) dose-response curves. The ECt(50) and the ECm(50), derived from the dose-response curves, were higher in children than in adults: ECm(50): 4.0 (3.6-4.5) microg/mL vs 3.3 (3.0-3.7) microg/mL [mean (95% CI)], P < 0.001; as well were the Ct and Cm clinically obtained when BIS was targeted at 50 (Cm(50): 4.3 +/- 1.1 microg/mL vs 3.4 +/- 1.2 microg/mL, (mean +/- SD) P < 0.05, children versus adults). Cm was generally under-estimated by the Ct, and the bias was higher in children than in adults: 2.6 +/- 2.6 microg/mL vs 1.7 +/- 1.6 microg/mL (P = 0.05). CONCLUSIONS: The good relationship between propofol and BIS demonstrated in children as in adults suggested a slightly lower sensitivity to propofol in children. As the predictability of plasma propofol concentrations with the classical pharmacokinetic/pharmacodynamic models is limited in children, a cerebral pharmacodynamic feedback, such as BIS, may be useful in this population. SN - 1526-7598 UR - https://www.unboundmedicine.com/medline/citation/18349180/The_relationship_between_bispectral_index_and_propofol_during_target_controlled_infusion_anesthesia:_a_comparative_study_between_children_and_young_adults_ L2 - https://doi.org/10.1213/ane.0b013e318164f388 DB - PRIME DP - Unbound Medicine ER -