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Hepatitis B virus DNA in liver tissue and risk for hepatocarcinogenesis in patients with hepatitis C virus-related chronic liver disease. A prospective study.
Intervirology 2008; 51(1):59-68I

Abstract

AIMS

To prospectively study whether occult hepatitis B virus (HBV) infection can promote the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV)-related chronic liver disease. In addition, to evaluate the difference among HBV DNA-negative patients and patients with high and low HBV copy numbers.

METHODS

A total of 167 patients with HCV-related chronic liver disease without HBV surface antigen (HBsAg) were studied. HBV DNA in liver tissue was determined using polymerase chain reaction (PCR).

RESULTS

HBV DNA was detected in 9 of 167 patients (5.4%) by single PCR and in 25 patients (15.0%) by nested PCR. HCC developed in 12 of 167 patients (7.2%). Ten of 142 HBV DNA-negative patients (7.0%) and 2 of 9 patients with a high HBV copy number (22.2%) developed HCC, whereas none of 16 patients with a low HBV copy number developed HCC. The incidence rate of HCC in patients with a high HBV copy number was significantly higher than in HBV DNA-negative patients and patients with low HBV copy number.

CONCLUSION

A high amount of HBV DNA in liver tissue of HBsAg-negative patients with HCV-related liver disease might be associated with HCC development.

Authors+Show Affiliations

Department of Laboratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. gmd16802@cc.okayama-u.ac.jp

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18349544

Citation

Obika, Mikako, et al. "Hepatitis B Virus DNA in Liver Tissue and Risk for Hepatocarcinogenesis in Patients With Hepatitis C Virus-related Chronic Liver Disease. a Prospective Study." Intervirology, vol. 51, no. 1, 2008, pp. 59-68.
Obika M, Shinji T, Fujioka S, et al. Hepatitis B virus DNA in liver tissue and risk for hepatocarcinogenesis in patients with hepatitis C virus-related chronic liver disease. A prospective study. Intervirology. 2008;51(1):59-68.
Obika, M., Shinji, T., Fujioka, S., Terada, R., Ryuko, H., Lwin, A. A., ... Koide, N. (2008). Hepatitis B virus DNA in liver tissue and risk for hepatocarcinogenesis in patients with hepatitis C virus-related chronic liver disease. A prospective study. Intervirology, 51(1), pp. 59-68. doi:10.1159/000121363.
Obika M, et al. Hepatitis B Virus DNA in Liver Tissue and Risk for Hepatocarcinogenesis in Patients With Hepatitis C Virus-related Chronic Liver Disease. a Prospective Study. Intervirology. 2008;51(1):59-68. PubMed PMID: 18349544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis B virus DNA in liver tissue and risk for hepatocarcinogenesis in patients with hepatitis C virus-related chronic liver disease. A prospective study. AU - Obika,Mikako, AU - Shinji,Toshiyuki, AU - Fujioka,Shin-Ichi, AU - Terada,Ryo, AU - Ryuko,Hiromasa, AU - Lwin,Aye Aye, AU - Shiraha,Hidenori, AU - Koide,Norio, Y1 - 2008/03/18/ PY - 2007/10/08/received PY - 2008/02/04/accepted PY - 2008/3/20/pubmed PY - 2008/4/19/medline PY - 2008/3/20/entrez SP - 59 EP - 68 JF - Intervirology JO - Intervirology VL - 51 IS - 1 N2 - AIMS: To prospectively study whether occult hepatitis B virus (HBV) infection can promote the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV)-related chronic liver disease. In addition, to evaluate the difference among HBV DNA-negative patients and patients with high and low HBV copy numbers. METHODS: A total of 167 patients with HCV-related chronic liver disease without HBV surface antigen (HBsAg) were studied. HBV DNA in liver tissue was determined using polymerase chain reaction (PCR). RESULTS: HBV DNA was detected in 9 of 167 patients (5.4%) by single PCR and in 25 patients (15.0%) by nested PCR. HCC developed in 12 of 167 patients (7.2%). Ten of 142 HBV DNA-negative patients (7.0%) and 2 of 9 patients with a high HBV copy number (22.2%) developed HCC, whereas none of 16 patients with a low HBV copy number developed HCC. The incidence rate of HCC in patients with a high HBV copy number was significantly higher than in HBV DNA-negative patients and patients with low HBV copy number. CONCLUSION: A high amount of HBV DNA in liver tissue of HBsAg-negative patients with HCV-related liver disease might be associated with HCC development. SN - 1423-0100 UR - https://www.unboundmedicine.com/medline/citation/18349544/Hepatitis_B_virus_DNA_in_liver_tissue_and_risk_for_hepatocarcinogenesis_in_patients_with_hepatitis_C_virus_related_chronic_liver_disease__A_prospective_study_ L2 - https://www.karger.com?DOI=10.1159/000121363 DB - PRIME DP - Unbound Medicine ER -