Tags

Type your tag names separated by a space and hit enter

Risk factors for low bone mineral density in children and adolescents with inflammatory bowel disease.
Dig Dis Sci. 2008 Oct; 53(10):2746-53.DD

Abstract

OBJECTIVE

To evaluate bone mineral density of the lumbar spine in children and adolescents with inflammatory bowel disease, and to identify the clinical risk factors associated with low bone mineral density.

METHODS

Bone mineral density of the lumbar spine was evaluated using dual-energy X-ray absorptiometry (DXA) in 40 patients with inflammatory bowel disease. Patients were 11.8 (SD = 4.1) years old and most of them were male (52.5%). Multiple linear regression analysis was performed to identify potential associations between bone mineral density Z-score and age, height-for-age Z-score, BMI Z-score, cumulative corticosteroid dose in milligrams and in milligrams per kilogram, disease duration, number of relapses, and calcium intake according to the dietary reference intake.

RESULTS

Low bone mineral density (Z-score bellow -2) was observed in 25% of patients. Patients with Crohn's disease and ulcerative colitis had equivalent prevalence of low bone mineral density. Multiple linear regression models demonstrated that height-for-age Z-score, BMI Z-score, and cumulative corticosteroid dose in mg had independent effects on BMD, respectively, beta = 0.492 (P = 0.000), beta = 0.460 (P = 0.001), beta = - 0.014 (P = 0.000), and these effects remained significant after adjustments for disease duration, respectively, beta = 0.489 (P = 0.013), beta = 0.467 (P = 0.001), and beta = - 0.005 (P = 0.015). The model accounted for 54.6% of the variability of the BMD Z-score (adjusted R2 = 0.546).

CONCLUSIONS

The prevalence of low bone mineral density in children and adolescents with inflammatory bowel disease is considerably high and independent risk factors associated with bone mineral density are corticosteroid cumulative dose in milligrams, height-for-age Z-score, and BMI Z-score.

Authors+Show Affiliations

Division of Pediatric Gastroenterology, Universidade Federal de São Paulo - Escola Paulista de Medicina, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18351466

Citation

Lopes, Letícia Helena Caldas, et al. "Risk Factors for Low Bone Mineral Density in Children and Adolescents With Inflammatory Bowel Disease." Digestive Diseases and Sciences, vol. 53, no. 10, 2008, pp. 2746-53.
Lopes LH, Sdepanian VL, Szejnfeld VL, et al. Risk factors for low bone mineral density in children and adolescents with inflammatory bowel disease. Dig Dis Sci. 2008;53(10):2746-53.
Lopes, L. H., Sdepanian, V. L., Szejnfeld, V. L., de Morais, M. B., & Fagundes-Neto, U. (2008). Risk factors for low bone mineral density in children and adolescents with inflammatory bowel disease. Digestive Diseases and Sciences, 53(10), 2746-53. https://doi.org/10.1007/s10620-008-0223-0
Lopes LH, et al. Risk Factors for Low Bone Mineral Density in Children and Adolescents With Inflammatory Bowel Disease. Dig Dis Sci. 2008;53(10):2746-53. PubMed PMID: 18351466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for low bone mineral density in children and adolescents with inflammatory bowel disease. AU - Lopes,Letícia Helena Caldas, AU - Sdepanian,Vera Lucia, AU - Szejnfeld,Vera Lúcia, AU - de Morais,Mauro Batista, AU - Fagundes-Neto,Ulysses, Y1 - 2008/03/20/ PY - 2006/08/30/received PY - 2008/02/19/accepted PY - 2008/3/21/pubmed PY - 2008/10/31/medline PY - 2008/3/21/entrez SP - 2746 EP - 53 JF - Digestive diseases and sciences JO - Dig Dis Sci VL - 53 IS - 10 N2 - OBJECTIVE: To evaluate bone mineral density of the lumbar spine in children and adolescents with inflammatory bowel disease, and to identify the clinical risk factors associated with low bone mineral density. METHODS: Bone mineral density of the lumbar spine was evaluated using dual-energy X-ray absorptiometry (DXA) in 40 patients with inflammatory bowel disease. Patients were 11.8 (SD = 4.1) years old and most of them were male (52.5%). Multiple linear regression analysis was performed to identify potential associations between bone mineral density Z-score and age, height-for-age Z-score, BMI Z-score, cumulative corticosteroid dose in milligrams and in milligrams per kilogram, disease duration, number of relapses, and calcium intake according to the dietary reference intake. RESULTS: Low bone mineral density (Z-score bellow -2) was observed in 25% of patients. Patients with Crohn's disease and ulcerative colitis had equivalent prevalence of low bone mineral density. Multiple linear regression models demonstrated that height-for-age Z-score, BMI Z-score, and cumulative corticosteroid dose in mg had independent effects on BMD, respectively, beta = 0.492 (P = 0.000), beta = 0.460 (P = 0.001), beta = - 0.014 (P = 0.000), and these effects remained significant after adjustments for disease duration, respectively, beta = 0.489 (P = 0.013), beta = 0.467 (P = 0.001), and beta = - 0.005 (P = 0.015). The model accounted for 54.6% of the variability of the BMD Z-score (adjusted R2 = 0.546). CONCLUSIONS: The prevalence of low bone mineral density in children and adolescents with inflammatory bowel disease is considerably high and independent risk factors associated with bone mineral density are corticosteroid cumulative dose in milligrams, height-for-age Z-score, and BMI Z-score. SN - 0163-2116 UR - https://www.unboundmedicine.com/medline/citation/18351466/Risk_factors_for_low_bone_mineral_density_in_children_and_adolescents_with_inflammatory_bowel_disease_ L2 - https://doi.org/10.1007/s10620-008-0223-0 DB - PRIME DP - Unbound Medicine ER -