Tags

Type your tag names separated by a space and hit enter

Hormonal and circulatory responses to chronically controlled increments in right atrial pressure.
Am J Physiol. 1991 Nov; 261(5 Pt 2):R1176-87.AJ

Abstract

To study the time-dependent changes in the secretion of atrial natriuretic peptide (ANP) in response to chronic stimulation by controlled increments in atrial pressure, we developed methodology for precise control of right atrial pressure (RAP) in dogs by employing an externally adjustable occluder around the pulmonary artery and a servo-control system. During 7 days of servo-control of RAP at 6.3 +/- 0.1 mmHg above control levels (1.3 +/- 0.1 mmHg), the 24-h coefficient of variation in RAP was 1/45 the variation that occurred under control conditions. After 30 min of increased RAP, mean arterial pressure (MAP) was reduced from 101 +/- 4 to 84 +/- 3 mmHg in association with increments in plasma renin activity (PRA) from 0.6 +/- 0.1 to 2.5 +/- 0.9 ng angiotensin I (ANG I).ml-1.h-1 and in the plasma concentrations of ANP, arginine vasopressin (AVP), and epinephrine from 93 +/- 18 to 484 +/- 61 pg/ml, from 0.5 +/- 0.1 to 9.2 +/- 2.4 pg/ml, and from 82 +/- 27 to 585 +/- 133 pg/ml, respectively. In comparison, on day 7 of servo-control of RAP, sodium balance was achieved and MAP remained depressed (82 +/- 4 mmHg) along with sustained increments in both plasma ANP concentration (482 +/- 67 pg/ml) and PRA (1.7 +/- 0.6 ng ANG I.ml-1.h-1); on the other hand, the plasma concentrations of AVP and epinephrine returned to control levels. This quantitative study indicates that ANP secretion does not chronically adapt to stimulation by increased atrial pressure and suggests that the plasma levels of ANP achieved in heart failure markedly increase renal excretory capability and allow fluid balance to be achieved at a substantial fall in renal perfusion pressure.

Authors+Show Affiliations

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1835308

Citation

Shin, Y, et al. "Hormonal and Circulatory Responses to Chronically Controlled Increments in Right Atrial Pressure." The American Journal of Physiology, vol. 261, no. 5 Pt 2, 1991, pp. R1176-87.
Shin Y, Lohmeier TE, Hester RL, et al. Hormonal and circulatory responses to chronically controlled increments in right atrial pressure. Am J Physiol. 1991;261(5 Pt 2):R1176-87.
Shin, Y., Lohmeier, T. E., Hester, R. L., Kivlighn, S. D., & Smith, M. J. (1991). Hormonal and circulatory responses to chronically controlled increments in right atrial pressure. The American Journal of Physiology, 261(5 Pt 2), R1176-87.
Shin Y, et al. Hormonal and Circulatory Responses to Chronically Controlled Increments in Right Atrial Pressure. Am J Physiol. 1991;261(5 Pt 2):R1176-87. PubMed PMID: 1835308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormonal and circulatory responses to chronically controlled increments in right atrial pressure. AU - Shin,Y, AU - Lohmeier,T E, AU - Hester,R L, AU - Kivlighn,S D, AU - Smith,M J,Jr PY - 1991/11/11/pubmed PY - 1991/11/11/medline PY - 1991/11/11/entrez SP - R1176 EP - 87 JF - The American journal of physiology JO - Am J Physiol VL - 261 IS - 5 Pt 2 N2 - To study the time-dependent changes in the secretion of atrial natriuretic peptide (ANP) in response to chronic stimulation by controlled increments in atrial pressure, we developed methodology for precise control of right atrial pressure (RAP) in dogs by employing an externally adjustable occluder around the pulmonary artery and a servo-control system. During 7 days of servo-control of RAP at 6.3 +/- 0.1 mmHg above control levels (1.3 +/- 0.1 mmHg), the 24-h coefficient of variation in RAP was 1/45 the variation that occurred under control conditions. After 30 min of increased RAP, mean arterial pressure (MAP) was reduced from 101 +/- 4 to 84 +/- 3 mmHg in association with increments in plasma renin activity (PRA) from 0.6 +/- 0.1 to 2.5 +/- 0.9 ng angiotensin I (ANG I).ml-1.h-1 and in the plasma concentrations of ANP, arginine vasopressin (AVP), and epinephrine from 93 +/- 18 to 484 +/- 61 pg/ml, from 0.5 +/- 0.1 to 9.2 +/- 2.4 pg/ml, and from 82 +/- 27 to 585 +/- 133 pg/ml, respectively. In comparison, on day 7 of servo-control of RAP, sodium balance was achieved and MAP remained depressed (82 +/- 4 mmHg) along with sustained increments in both plasma ANP concentration (482 +/- 67 pg/ml) and PRA (1.7 +/- 0.6 ng ANG I.ml-1.h-1); on the other hand, the plasma concentrations of AVP and epinephrine returned to control levels. This quantitative study indicates that ANP secretion does not chronically adapt to stimulation by increased atrial pressure and suggests that the plasma levels of ANP achieved in heart failure markedly increase renal excretory capability and allow fluid balance to be achieved at a substantial fall in renal perfusion pressure. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/1835308/Hormonal_and_circulatory_responses_to_chronically_controlled_increments_in_right_atrial_pressure_ L2 - https://journals.physiology.org/doi/10.1152/ajpregu.1991.261.5.R1176?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -