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Topical isoflavones provide effective photoprotection to skin.
Photodermatol Photoimmunol Photomed. 2008 Apr; 24(2):61-6.PP

Abstract

BACKGROUND/PURPOSE

Isoflavones, one main group of phytoestrogens, have antioxidative and photoprotective effects in cellular and mouse studies. The aim of this study is to obtain a more comprehensive understanding of the isoflavone-mediated photoprotection with the pig skin model, a more human-resembling model.

METHODS

The pig skin was treated with five well-known isoflavone compounds (genistein, equol, daidzein, biochanin A, and formononetin) and one antioxidant combination solution of 15% vitamin C and 1% vitamin E and 0.5% ferulic acid (CEF) daily for 4 days. Skin was irradiated with solar-simulated UV irradiation, 1 to 5 minimal erythema dose (MED) at 1-MED intervals. Evaluation was carried out 24 h later by colorimeter-measured erythema and sunburn cell numbers.

RESULTS

Topical application of 0.5% solutions of three individual phytoestrogens - genistein, daidzein, biochanin A - are better than similar solutions of equol or formononetin in protecting pig skin from solar-simulated ultraviolet (SSUV)-induced photodamage, as measured by sunburn cell formation and/or erythema. However, the protection was less than that provided by a topical combination antioxidant standard containing 15% L-ascorbic acid, 1%alpha-tocopherol, and 0.5% ferulic acid.

CONCLUSION

Isoflavones provide effective photoprotection and are good candidate ingredients for protection against ultraviolet (UV) photodamage.

Authors+Show Affiliations

Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan. lindajylin@adm.cgmh.org.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18353084

Citation

Lin, Jing-Yi, et al. "Topical Isoflavones Provide Effective Photoprotection to Skin." Photodermatology, Photoimmunology & Photomedicine, vol. 24, no. 2, 2008, pp. 61-6.
Lin JY, Tournas JA, Burch JA, et al. Topical isoflavones provide effective photoprotection to skin. Photodermatol Photoimmunol Photomed. 2008;24(2):61-6.
Lin, J. Y., Tournas, J. A., Burch, J. A., Monteiro-Riviere, N. A., & Zielinski, J. (2008). Topical isoflavones provide effective photoprotection to skin. Photodermatology, Photoimmunology & Photomedicine, 24(2), 61-6. https://doi.org/10.1111/j.1600-0781.2008.00329.x
Lin JY, et al. Topical Isoflavones Provide Effective Photoprotection to Skin. Photodermatol Photoimmunol Photomed. 2008;24(2):61-6. PubMed PMID: 18353084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Topical isoflavones provide effective photoprotection to skin. AU - Lin,Jing-Yi, AU - Tournas,Joshua A, AU - Burch,James A, AU - Monteiro-Riviere,Nancy A, AU - Zielinski,Jan, PY - 2008/3/21/pubmed PY - 2008/4/16/medline PY - 2008/3/21/entrez SP - 61 EP - 6 JF - Photodermatology, photoimmunology & photomedicine JO - Photodermatol Photoimmunol Photomed VL - 24 IS - 2 N2 - BACKGROUND/PURPOSE: Isoflavones, one main group of phytoestrogens, have antioxidative and photoprotective effects in cellular and mouse studies. The aim of this study is to obtain a more comprehensive understanding of the isoflavone-mediated photoprotection with the pig skin model, a more human-resembling model. METHODS: The pig skin was treated with five well-known isoflavone compounds (genistein, equol, daidzein, biochanin A, and formononetin) and one antioxidant combination solution of 15% vitamin C and 1% vitamin E and 0.5% ferulic acid (CEF) daily for 4 days. Skin was irradiated with solar-simulated UV irradiation, 1 to 5 minimal erythema dose (MED) at 1-MED intervals. Evaluation was carried out 24 h later by colorimeter-measured erythema and sunburn cell numbers. RESULTS: Topical application of 0.5% solutions of three individual phytoestrogens - genistein, daidzein, biochanin A - are better than similar solutions of equol or formononetin in protecting pig skin from solar-simulated ultraviolet (SSUV)-induced photodamage, as measured by sunburn cell formation and/or erythema. However, the protection was less than that provided by a topical combination antioxidant standard containing 15% L-ascorbic acid, 1%alpha-tocopherol, and 0.5% ferulic acid. CONCLUSION: Isoflavones provide effective photoprotection and are good candidate ingredients for protection against ultraviolet (UV) photodamage. SN - 1600-0781 UR - https://www.unboundmedicine.com/medline/citation/18353084/Topical_isoflavones_provide_effective_photoprotection_to_skin_ L2 - https://doi.org/10.1111/j.1600-0781.2008.00329.x DB - PRIME DP - Unbound Medicine ER -