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Effect of ondansetron on the incidence of vomiting associated with ketamine sedation in children: a double-blind, randomized, placebo-controlled trial.
Ann Emerg Med. 2008 Jul; 52(1):30-4.AE

Abstract

STUDY OBJECTIVE

We investigate the effect of ondansetron on the incidence of vomiting in children who receive intravenous (IV) ketamine for procedural sedation and analgesia in the emergency department (ED).

METHODS

In this double-blind, randomized, placebo-controlled trial in a children's hospital ED, patients receiving IV ketamine (1 mg/kg) for ED procedures were randomized to receive either IV ondansetron (0.15 mg/kg; maximum 4 mg) or identical placebo. We recorded whether vomiting occurred in the ED postsedation or up to 12 hours after discharge with telephone follow-up and compared ED length of stay and parental satisfaction.

RESULTS

One hundred twenty-seven children were randomized to placebo and 128 to ondansetron. The groups were similar in age, sex, and fasting duration. ED vomiting was less common with ondansetron: 6 of 128 (4.7%) versus 16 of 127 (12.6%), P=.02, difference 7.9% (95% confidence interval 1.1% to 14.7%), number needed to treat 13. Follow-up was successful in 82.7%, with vomiting in the ED or after discharge less frequent with ondansetron: 10 of 128 (7.8%) versus 24 of 127 (18.9%), P=.01, difference 11.1% (95% confidence interval 2.7% to 19.5%), number needed to treat 9. ED length of stay and parental satisfaction were similar between groups.

CONCLUSION

IV ondansetron significantly reduces the incidence of vomiting associated with IV ketamine procedural sedation in children.

Authors+Show Affiliations

Department of Pediatrics, Section of Emergency Medicine, Children's Hospital of Austin, Austin, TX, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18353503

Citation

Langston, William T., et al. "Effect of Ondansetron On the Incidence of Vomiting Associated With Ketamine Sedation in Children: a Double-blind, Randomized, Placebo-controlled Trial." Annals of Emergency Medicine, vol. 52, no. 1, 2008, pp. 30-4.
Langston WT, Wathen JE, Roback MG, et al. Effect of ondansetron on the incidence of vomiting associated with ketamine sedation in children: a double-blind, randomized, placebo-controlled trial. Ann Emerg Med. 2008;52(1):30-4.
Langston, W. T., Wathen, J. E., Roback, M. G., & Bajaj, L. (2008). Effect of ondansetron on the incidence of vomiting associated with ketamine sedation in children: a double-blind, randomized, placebo-controlled trial. Annals of Emergency Medicine, 52(1), 30-4. https://doi.org/10.1016/j.annemergmed.2008.01.326
Langston WT, et al. Effect of Ondansetron On the Incidence of Vomiting Associated With Ketamine Sedation in Children: a Double-blind, Randomized, Placebo-controlled Trial. Ann Emerg Med. 2008;52(1):30-4. PubMed PMID: 18353503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of ondansetron on the incidence of vomiting associated with ketamine sedation in children: a double-blind, randomized, placebo-controlled trial. AU - Langston,William T, AU - Wathen,Joe E, AU - Roback,Mark G, AU - Bajaj,Lalit, Y1 - 2008/03/19/ PY - 2007/11/05/received PY - 2008/01/16/revised PY - 2008/01/22/accepted PY - 2008/3/21/pubmed PY - 2008/7/31/medline PY - 2008/3/21/entrez SP - 30 EP - 4 JF - Annals of emergency medicine JO - Ann Emerg Med VL - 52 IS - 1 N2 - STUDY OBJECTIVE: We investigate the effect of ondansetron on the incidence of vomiting in children who receive intravenous (IV) ketamine for procedural sedation and analgesia in the emergency department (ED). METHODS: In this double-blind, randomized, placebo-controlled trial in a children's hospital ED, patients receiving IV ketamine (1 mg/kg) for ED procedures were randomized to receive either IV ondansetron (0.15 mg/kg; maximum 4 mg) or identical placebo. We recorded whether vomiting occurred in the ED postsedation or up to 12 hours after discharge with telephone follow-up and compared ED length of stay and parental satisfaction. RESULTS: One hundred twenty-seven children were randomized to placebo and 128 to ondansetron. The groups were similar in age, sex, and fasting duration. ED vomiting was less common with ondansetron: 6 of 128 (4.7%) versus 16 of 127 (12.6%), P=.02, difference 7.9% (95% confidence interval 1.1% to 14.7%), number needed to treat 13. Follow-up was successful in 82.7%, with vomiting in the ED or after discharge less frequent with ondansetron: 10 of 128 (7.8%) versus 24 of 127 (18.9%), P=.01, difference 11.1% (95% confidence interval 2.7% to 19.5%), number needed to treat 9. ED length of stay and parental satisfaction were similar between groups. CONCLUSION: IV ondansetron significantly reduces the incidence of vomiting associated with IV ketamine procedural sedation in children. SN - 1097-6760 UR - https://www.unboundmedicine.com/medline/citation/18353503/Effect_of_ondansetron_on_the_incidence_of_vomiting_associated_with_ketamine_sedation_in_children:_a_double_blind_randomized_placebo_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0196-0644(08)00364-8 DB - PRIME DP - Unbound Medicine ER -