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D-cycloserine facilitates extinction the first time but not the second time: an examination of the role of NMDA across the course of repeated extinction sessions.
Neuropsychopharmacology. 2008 Dec; 33(13):3096-102.N

Abstract

Extinction of learned fear is facilitated by the partial NMDA agonist D-cycloserine (DCS). However, some studies suggest that the involvement of NMDA in learning differs depending on whether learning is for the first or second time. The current study aimed to extend these findings by examining the role of NMDA in extinction for the first and the second time. Specifically, the present series of experiments used Pavlovian fear conditioning and extinction paradigms to compare the effect of DCS on extinction of fear to a light CS the first and second time around. As found previously, DCS facilitated extinction of learned fear (Experiment 1). A novel finding, however, was that DCS did not facilitate the re-extinction of fear to this same CS following retraining (Experiments 2A and 2B). Finally, it was demonstrated that the transition from NMDA-dependent to NMDA-independent extinction was stimulus specific (Experiment 3). That is, rats were first trained to fear a CS (light); this fear was then extinguished. Following this, rats were then retrained to fear the same CS (light) or a new CS (white noise). When given a second extinction session, DCS was found to facilitate extinction of the new CS but not the original CS. The results of this series of experiments suggest that the role of NMDA in extinction depends on whether extinction is new learning (first extinction) or retrieval of a previous extinction memory (re-extinction).

Authors+Show Affiliations

School of Psychology, The University of New South Wales, Sydney, NSW, Australia. jlangton@psy.unsw.edu.auNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18354389

Citation

Langton, Julia M., and Rick Richardson. "D-cycloserine Facilitates Extinction the First Time but Not the Second Time: an Examination of the Role of NMDA Across the Course of Repeated Extinction Sessions." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 33, no. 13, 2008, pp. 3096-102.
Langton JM, Richardson R. D-cycloserine facilitates extinction the first time but not the second time: an examination of the role of NMDA across the course of repeated extinction sessions. Neuropsychopharmacology. 2008;33(13):3096-102.
Langton, J. M., & Richardson, R. (2008). D-cycloserine facilitates extinction the first time but not the second time: an examination of the role of NMDA across the course of repeated extinction sessions. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 33(13), 3096-102. https://doi.org/10.1038/npp.2008.32
Langton JM, Richardson R. D-cycloserine Facilitates Extinction the First Time but Not the Second Time: an Examination of the Role of NMDA Across the Course of Repeated Extinction Sessions. Neuropsychopharmacology. 2008;33(13):3096-102. PubMed PMID: 18354389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - D-cycloserine facilitates extinction the first time but not the second time: an examination of the role of NMDA across the course of repeated extinction sessions. AU - Langton,Julia M, AU - Richardson,Rick, Y1 - 2008/03/19/ PY - 2008/3/21/pubmed PY - 2009/2/20/medline PY - 2008/3/21/entrez SP - 3096 EP - 102 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 33 IS - 13 N2 - Extinction of learned fear is facilitated by the partial NMDA agonist D-cycloserine (DCS). However, some studies suggest that the involvement of NMDA in learning differs depending on whether learning is for the first or second time. The current study aimed to extend these findings by examining the role of NMDA in extinction for the first and the second time. Specifically, the present series of experiments used Pavlovian fear conditioning and extinction paradigms to compare the effect of DCS on extinction of fear to a light CS the first and second time around. As found previously, DCS facilitated extinction of learned fear (Experiment 1). A novel finding, however, was that DCS did not facilitate the re-extinction of fear to this same CS following retraining (Experiments 2A and 2B). Finally, it was demonstrated that the transition from NMDA-dependent to NMDA-independent extinction was stimulus specific (Experiment 3). That is, rats were first trained to fear a CS (light); this fear was then extinguished. Following this, rats were then retrained to fear the same CS (light) or a new CS (white noise). When given a second extinction session, DCS was found to facilitate extinction of the new CS but not the original CS. The results of this series of experiments suggest that the role of NMDA in extinction depends on whether extinction is new learning (first extinction) or retrieval of a previous extinction memory (re-extinction). SN - 1740-634X UR - https://www.unboundmedicine.com/medline/citation/18354389/D_cycloserine_facilitates_extinction_the_first_time_but_not_the_second_time:_an_examination_of_the_role_of_NMDA_across_the_course_of_repeated_extinction_sessions_ DB - PRIME DP - Unbound Medicine ER -