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The methylenetetrahydrofolate reductase 677C>T gene polymorphism is not associated with chronic plaque psoriasis.
Exp Dermatol 2008; 17(9):748-51ED

Abstract

BACKGROUND

Methylenetetrahydrofolate reductase (MTHFR) is involved in the formation of methyl donors, which contribute to DNA methylation. DNA methylation is an essential epigenetic feature playing a critical role in gene regulation and cellular differentiation. In addition, MTHFR activity affects plasma homocysteine levels. A functional polymorphism in the MTHFR gene (677C>T, rs1801133) leading to reduced enzyme activity has been associated with chronic plaque psoriasis in a Chinese population. This finding, however, has not yet been either confirmed or refuted in other populations. The purpose of the present study was to investigate a hypothesized association between the MTHFR 677C>T polymorphism and the presence of chronic plaque psoriasis in a Caucasian population.

METHODS

Genotypes for the MTHFR 677C>T polymorphism were determined in 310 patients and 247 control subjects. In a subgroup of 33 patients and 33 sex- and age-matched control subjects, fasting plasma homocysteine concentrations were determined by high-performance liquid chromatography and immunological assays were used for the measurement of folate and vitamin B(12).

RESULTS

Prevalence of the homozygous MTHFR 677TT genotype did not significantly differ between patients and controls (15.2% vs 11.7%, P = 0.24). Mean plasma homocysteine concentrations were significantly higher in psoriasis patients than among control subjects (13.5 +/- 5.3 micromol/l vs 11.0 +/- 2.2 micromol/l, P = 0.026). No significant differences between either mean plasma folate or vitamin B(12) concentrations were observed between both groups.

CONCLUSION

Our data suggest that the MTHFR 677C>T gene polymorphism is not associated with chronic plaque psoriasis among Caucasians.

Authors+Show Affiliations

Department of Dermatology, Medical University of Graz, Austria. wolfgang.weger@klinikum-graz.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18355300

Citation

Weger, Wolfgang, et al. "The Methylenetetrahydrofolate Reductase 677C>T Gene Polymorphism Is Not Associated With Chronic Plaque Psoriasis." Experimental Dermatology, vol. 17, no. 9, 2008, pp. 748-51.
Weger W, Hofer A, Stanger O, et al. The methylenetetrahydrofolate reductase 677C>T gene polymorphism is not associated with chronic plaque psoriasis. Exp Dermatol. 2008;17(9):748-51.
Weger, W., Hofer, A., Stanger, O., Wolf, P., El-Shabrawi, Y., Renner, W., ... Salmhofer, W. (2008). The methylenetetrahydrofolate reductase 677C>T gene polymorphism is not associated with chronic plaque psoriasis. Experimental Dermatology, 17(9), pp. 748-51. doi:10.1111/j.1600-0625.2008.00713.x.
Weger W, et al. The Methylenetetrahydrofolate Reductase 677C>T Gene Polymorphism Is Not Associated With Chronic Plaque Psoriasis. Exp Dermatol. 2008;17(9):748-51. PubMed PMID: 18355300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The methylenetetrahydrofolate reductase 677C>T gene polymorphism is not associated with chronic plaque psoriasis. AU - Weger,Wolfgang, AU - Hofer,Angelika, AU - Stanger,Olaf, AU - Wolf,Peter, AU - El-Shabrawi,Yosuf, AU - Renner,Wilfried, AU - Kerl,Helmut, AU - Salmhofer,Wolfgang, Y1 - 2008/03/18/ PY - 2008/3/22/pubmed PY - 2008/12/17/medline PY - 2008/3/22/entrez SP - 748 EP - 51 JF - Experimental dermatology JO - Exp. Dermatol. VL - 17 IS - 9 N2 - BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is involved in the formation of methyl donors, which contribute to DNA methylation. DNA methylation is an essential epigenetic feature playing a critical role in gene regulation and cellular differentiation. In addition, MTHFR activity affects plasma homocysteine levels. A functional polymorphism in the MTHFR gene (677C>T, rs1801133) leading to reduced enzyme activity has been associated with chronic plaque psoriasis in a Chinese population. This finding, however, has not yet been either confirmed or refuted in other populations. The purpose of the present study was to investigate a hypothesized association between the MTHFR 677C>T polymorphism and the presence of chronic plaque psoriasis in a Caucasian population. METHODS: Genotypes for the MTHFR 677C>T polymorphism were determined in 310 patients and 247 control subjects. In a subgroup of 33 patients and 33 sex- and age-matched control subjects, fasting plasma homocysteine concentrations were determined by high-performance liquid chromatography and immunological assays were used for the measurement of folate and vitamin B(12). RESULTS: Prevalence of the homozygous MTHFR 677TT genotype did not significantly differ between patients and controls (15.2% vs 11.7%, P = 0.24). Mean plasma homocysteine concentrations were significantly higher in psoriasis patients than among control subjects (13.5 +/- 5.3 micromol/l vs 11.0 +/- 2.2 micromol/l, P = 0.026). No significant differences between either mean plasma folate or vitamin B(12) concentrations were observed between both groups. CONCLUSION: Our data suggest that the MTHFR 677C>T gene polymorphism is not associated with chronic plaque psoriasis among Caucasians. SN - 1600-0625 UR - https://www.unboundmedicine.com/medline/citation/18355300/The_methylenetetrahydrofolate_reductase_677C>T_gene_polymorphism_is_not_associated_with_chronic_plaque_psoriasis_ L2 - https://doi.org/10.1111/j.1600-0625.2008.00713.x DB - PRIME DP - Unbound Medicine ER -