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Antidepressant-like effects of the CRF family peptides, urocortin 1, urocortin 2 and urocortin 3 in a modified forced swimming test in mice.
Brain Res Bull. 2008 Mar 28; 75(5):509-12.BR

Abstract

Most of the evidence suggests that corticotropin-releasing hormone (CRH) is involved in mood disorders. The CRF receptors type 1 (CRF(1) receptors) elicit a stress response, and their natural and synthetic antagonists have been studied as possible drugs against depression, whereas CRF receptors type 2 (CRF(2) receptors) appear to alleviate the stress response and mediate anxiolytic action. Other CRF family peptides are urocortin 1 (Ucn 1), urocortin 2 (Ucn 2) and urocortin 3 (Ucn 3). Little is known about the action of Ucn 1, Ucn 2 and Ucn 3 on depressive disorders. Antidepressant-like effects of Ucn 1, Ucn 2 and Ucn 3 (0.13, 0.25 and 0.5 microg/2 microl, i.c.v.) were assayed in mice in a modified forced swimming test (FST). This modified FST predicts the clinical efficacy of an antidepressant drug through the scoring of immobility, climbing and swimming behavior. The study demonstrated that Ucn 1 had no action on any of parameters studied in the modified FST. Ucn 2 elicited antidepressive-like action by shortening the immobility time. Additionally Ucn 2 significantly increased the climbing and swimming times. Ucn 3 likewise displayed an antidepressive-like effect by shortening the immobility time, and increasing the climbing and swimming times. The results suggest that CRF(2) receptor stimulation by Ucn 2 or Ucn 3 leads to antidepressant-like action, but dual stimulation of the CRF(1) and CRF(2) receptors by Ucn 1 does not trigger antidepressant-like action in the modified mouse FST.

Authors+Show Affiliations

Institute of Pathophysiology, University of Szeged, Semmelweis u. 1, H-6701 Szeged, Hungary.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18355626

Citation

Tanaka, Masaru, and Gyula Telegdy. "Antidepressant-like Effects of the CRF Family Peptides, Urocortin 1, Urocortin 2 and Urocortin 3 in a Modified Forced Swimming Test in Mice." Brain Research Bulletin, vol. 75, no. 5, 2008, pp. 509-12.
Tanaka M, Telegdy G. Antidepressant-like effects of the CRF family peptides, urocortin 1, urocortin 2 and urocortin 3 in a modified forced swimming test in mice. Brain Res Bull. 2008;75(5):509-12.
Tanaka, M., & Telegdy, G. (2008). Antidepressant-like effects of the CRF family peptides, urocortin 1, urocortin 2 and urocortin 3 in a modified forced swimming test in mice. Brain Research Bulletin, 75(5), 509-12. https://doi.org/10.1016/j.brainresbull.2007.08.009
Tanaka M, Telegdy G. Antidepressant-like Effects of the CRF Family Peptides, Urocortin 1, Urocortin 2 and Urocortin 3 in a Modified Forced Swimming Test in Mice. Brain Res Bull. 2008 Mar 28;75(5):509-12. PubMed PMID: 18355626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidepressant-like effects of the CRF family peptides, urocortin 1, urocortin 2 and urocortin 3 in a modified forced swimming test in mice. AU - Tanaka,Masaru, AU - Telegdy,Gyula, Y1 - 2007/09/25/ PY - 2007/07/05/received PY - 2007/08/30/revised PY - 2007/08/31/accepted PY - 2008/3/22/pubmed PY - 2008/7/11/medline PY - 2008/3/22/entrez SP - 509 EP - 12 JF - Brain research bulletin JO - Brain Res. Bull. VL - 75 IS - 5 N2 - Most of the evidence suggests that corticotropin-releasing hormone (CRH) is involved in mood disorders. The CRF receptors type 1 (CRF(1) receptors) elicit a stress response, and their natural and synthetic antagonists have been studied as possible drugs against depression, whereas CRF receptors type 2 (CRF(2) receptors) appear to alleviate the stress response and mediate anxiolytic action. Other CRF family peptides are urocortin 1 (Ucn 1), urocortin 2 (Ucn 2) and urocortin 3 (Ucn 3). Little is known about the action of Ucn 1, Ucn 2 and Ucn 3 on depressive disorders. Antidepressant-like effects of Ucn 1, Ucn 2 and Ucn 3 (0.13, 0.25 and 0.5 microg/2 microl, i.c.v.) were assayed in mice in a modified forced swimming test (FST). This modified FST predicts the clinical efficacy of an antidepressant drug through the scoring of immobility, climbing and swimming behavior. The study demonstrated that Ucn 1 had no action on any of parameters studied in the modified FST. Ucn 2 elicited antidepressive-like action by shortening the immobility time. Additionally Ucn 2 significantly increased the climbing and swimming times. Ucn 3 likewise displayed an antidepressive-like effect by shortening the immobility time, and increasing the climbing and swimming times. The results suggest that CRF(2) receptor stimulation by Ucn 2 or Ucn 3 leads to antidepressant-like action, but dual stimulation of the CRF(1) and CRF(2) receptors by Ucn 1 does not trigger antidepressant-like action in the modified mouse FST. SN - 0361-9230 UR - https://www.unboundmedicine.com/medline/citation/18355626/Antidepressant_like_effects_of_the_CRF_family_peptides_urocortin_1_urocortin_2_and_urocortin_3_in_a_modified_forced_swimming_test_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(07)00279-1 DB - PRIME DP - Unbound Medicine ER -