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Is there an association between hypothyroidism and open-angle glaucoma in an elderly population? An epidemiologic study.
Ophthalmology 2008; 115(9):1581-4O

Abstract

PURPOSE

There have been conflicting reports pertaining to the association between hypothyroidism and open-angle glaucoma (OAG). The purpose of this study was to assess the hypothesized association between preexisting hypothyroidism and development of OAG in a population-based setting.

DESIGN

Case-control study.

PARTICIPANTS

The study population and controls were taken from all patients in a large US managed care database aged >or=60 years with 4 years of continuous eligibility dating from January 1, 2001, through December 31, 2004.

METHODS

A total of 4728 newly diagnosed OAG patients were matched with 14 184 controls (3:1 matching) based on age and gender.

MAIN OUTCOME MEASURES

Conditional logistic regression was used to assess the relationship between hypothyroidism and OAG while controlling for various risk factors (ischemic heart disease, cerebrovascular disease, hyperlipidemia, hypertension, arterial disease, diabetes, and migraines).

RESULTS

Based on a diagnosis of hypothyroidism or use of a thyroid replacement therapy, prior hypothyroidism was found in 815 (17.2%) OAG subjects and in 2498 (17.6%) control subjects. After adjusting for the specified risk factors, patients with OAG were not found to be associated with a prior hypothyroid diagnosis when compared with control subjects (odds ratio, 0.93; 95% confidence interval, 0.85-1.01).

CONCLUSIONS

An association between prior hypothyroidism and OAG development was not found. The large proportion of patients receiving thyroid replacement therapy may have negated any OAG-related consequences of hypothyroidism.

Authors+Show Affiliations

Degge Group, Ltd, Arlington, Virginia 22209, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18355921

Citation

Motsko, Stephen P., and Judith K. Jones. "Is There an Association Between Hypothyroidism and Open-angle Glaucoma in an Elderly Population? an Epidemiologic Study." Ophthalmology, vol. 115, no. 9, 2008, pp. 1581-4.
Motsko SP, Jones JK. Is there an association between hypothyroidism and open-angle glaucoma in an elderly population? An epidemiologic study. Ophthalmology. 2008;115(9):1581-4.
Motsko, S. P., & Jones, J. K. (2008). Is there an association between hypothyroidism and open-angle glaucoma in an elderly population? An epidemiologic study. Ophthalmology, 115(9), pp. 1581-4. doi:10.1016/j.ophtha.2008.01.016.
Motsko SP, Jones JK. Is There an Association Between Hypothyroidism and Open-angle Glaucoma in an Elderly Population? an Epidemiologic Study. Ophthalmology. 2008;115(9):1581-4. PubMed PMID: 18355921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is there an association between hypothyroidism and open-angle glaucoma in an elderly population? An epidemiologic study. AU - Motsko,Stephen P, AU - Jones,Judith K, Y1 - 2008/03/20/ PY - 2007/09/24/received PY - 2008/01/02/revised PY - 2008/01/17/accepted PY - 2008/3/22/pubmed PY - 2008/9/13/medline PY - 2008/3/22/entrez SP - 1581 EP - 4 JF - Ophthalmology JO - Ophthalmology VL - 115 IS - 9 N2 - PURPOSE: There have been conflicting reports pertaining to the association between hypothyroidism and open-angle glaucoma (OAG). The purpose of this study was to assess the hypothesized association between preexisting hypothyroidism and development of OAG in a population-based setting. DESIGN: Case-control study. PARTICIPANTS: The study population and controls were taken from all patients in a large US managed care database aged >or=60 years with 4 years of continuous eligibility dating from January 1, 2001, through December 31, 2004. METHODS: A total of 4728 newly diagnosed OAG patients were matched with 14 184 controls (3:1 matching) based on age and gender. MAIN OUTCOME MEASURES: Conditional logistic regression was used to assess the relationship between hypothyroidism and OAG while controlling for various risk factors (ischemic heart disease, cerebrovascular disease, hyperlipidemia, hypertension, arterial disease, diabetes, and migraines). RESULTS: Based on a diagnosis of hypothyroidism or use of a thyroid replacement therapy, prior hypothyroidism was found in 815 (17.2%) OAG subjects and in 2498 (17.6%) control subjects. After adjusting for the specified risk factors, patients with OAG were not found to be associated with a prior hypothyroid diagnosis when compared with control subjects (odds ratio, 0.93; 95% confidence interval, 0.85-1.01). CONCLUSIONS: An association between prior hypothyroidism and OAG development was not found. The large proportion of patients receiving thyroid replacement therapy may have negated any OAG-related consequences of hypothyroidism. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/18355921/Is_there_an_association_between_hypothyroidism_and_open_angle_glaucoma_in_an_elderly_population_An_epidemiologic_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(08)00070-5 DB - PRIME DP - Unbound Medicine ER -