TY - JOUR T1 - Quality of life and survival outcome for patients with nasopharyngeal carcinoma receiving three-dimensional conformal radiotherapy vs. intensity-modulated radiotherapy-a longitudinal study. AU - Fang,Fu-Min, AU - Chien,Chih-Yen, AU - Tsai,Wen-Ling, AU - Chen,Hui-Chun, AU - Hsu,Hsuan-Chih, AU - Lui,Chun-Chung, AU - Huang,Tai-Lin, AU - Huang,Hsuan-Ying, Y1 - 2008/03/20/ PY - 2007/09/13/received PY - 2007/12/24/revised PY - 2007/12/27/accepted PY - 2008/3/22/pubmed PY - 2008/10/22/medline PY - 2008/3/22/entrez SP - 356 EP - 64 JF - International journal of radiation oncology, biology, physics JO - Int J Radiat Oncol Biol Phys VL - 72 IS - 2 N2 - PURPOSE: To investigate the changes of quality of life (QoL) and survival outcomes for patients with nasopharyngeal carcinoma (NPC) treated by three-dimensional conformal radiotherapy (3D-CRT) vs. intensity-modulated radiotherapy (IMRT). METHODS AND MATERIALS: Two hundred and three newly diagnosed NPC patients, who were curatively treated by 3D-CRT (n = 93) or IMRT (n = 110) between March 2002 and July 2004, were analyzed. The distributions of clinical stage according to American Joint Committee on Cancer 1997 were I: 15 (7.4%), II: 78 (38.4%), III: 74 (36.5%), and IV: 36 (17.7%). QoL was longitudinally assessed by the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and the EORTC QLQ-H&N35 questionnaires at the five time points: before RT, during RT (36 Gy), and 3 months, 12 months, and 24 months after RT. RESULTS: The 3-year locoregional control, metastasis-free survival, and overall survival rates were 84.8%, 76.7%, and 81.7% for the 3D-CRT group, respectively, compared with 84.2%, 82.6%, and 85.4% for the IMRT group (p value > 0.05). A general trend of maximal deterioration in most QoL scales was observed during RT, followed by a gradual recovery thereafter. There was no significant difference in most scales between the two groups at each time point. The exception was that patients treated by IMRT had a both statistically and clinically significant improvement in global QoL, fatigue, taste/smell, dry mouth, and feeling ill at the time point of 3 months after RT. CONCLUSIONS: The potential advantage of IMRT over 3D-CRT in treating NPC patients might occur in QoL outcome during the recovery phase of acute toxicity. SN - 0360-3016 UR - https://www.unboundmedicine.com/medline/citation/18355980/Quality_of_life_and_survival_outcome_for_patients_with_nasopharyngeal_carcinoma_receiving_three_dimensional_conformal_radiotherapy_vs__intensity_modulated_radiotherapy_a_longitudinal_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0360-3016(08)00052-7 DB - PRIME DP - Unbound Medicine ER -