Tags

Type your tag names separated by a space and hit enter

Quality of life and survival outcome for patients with nasopharyngeal carcinoma receiving three-dimensional conformal radiotherapy vs. intensity-modulated radiotherapy-a longitudinal study.
Int J Radiat Oncol Biol Phys. 2008 Oct 01; 72(2):356-64.IJ

Abstract

PURPOSE

To investigate the changes of quality of life (QoL) and survival outcomes for patients with nasopharyngeal carcinoma (NPC) treated by three-dimensional conformal radiotherapy (3D-CRT) vs. intensity-modulated radiotherapy (IMRT).

METHODS AND MATERIALS

Two hundred and three newly diagnosed NPC patients, who were curatively treated by 3D-CRT (n = 93) or IMRT (n = 110) between March 2002 and July 2004, were analyzed. The distributions of clinical stage according to American Joint Committee on Cancer 1997 were I: 15 (7.4%), II: 78 (38.4%), III: 74 (36.5%), and IV: 36 (17.7%). QoL was longitudinally assessed by the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and the EORTC QLQ-H&N35 questionnaires at the five time points: before RT, during RT (36 Gy), and 3 months, 12 months, and 24 months after RT.

RESULTS

The 3-year locoregional control, metastasis-free survival, and overall survival rates were 84.8%, 76.7%, and 81.7% for the 3D-CRT group, respectively, compared with 84.2%, 82.6%, and 85.4% for the IMRT group (p value > 0.05). A general trend of maximal deterioration in most QoL scales was observed during RT, followed by a gradual recovery thereafter. There was no significant difference in most scales between the two groups at each time point. The exception was that patients treated by IMRT had a both statistically and clinically significant improvement in global QoL, fatigue, taste/smell, dry mouth, and feeling ill at the time point of 3 months after RT.

CONCLUSIONS

The potential advantage of IMRT over 3D-CRT in treating NPC patients might occur in QoL outcome during the recovery phase of acute toxicity.

Authors+Show Affiliations

Department of Radiation Oncology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan. fang2569@adm.cgmh.org.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18355980

Citation

Fang, Fu-Min, et al. "Quality of Life and Survival Outcome for Patients With Nasopharyngeal Carcinoma Receiving Three-dimensional Conformal Radiotherapy Vs. Intensity-modulated Radiotherapy-a Longitudinal Study." International Journal of Radiation Oncology, Biology, Physics, vol. 72, no. 2, 2008, pp. 356-64.
Fang FM, Chien CY, Tsai WL, et al. Quality of life and survival outcome for patients with nasopharyngeal carcinoma receiving three-dimensional conformal radiotherapy vs. intensity-modulated radiotherapy-a longitudinal study. Int J Radiat Oncol Biol Phys. 2008;72(2):356-64.
Fang, F. M., Chien, C. Y., Tsai, W. L., Chen, H. C., Hsu, H. C., Lui, C. C., Huang, T. L., & Huang, H. Y. (2008). Quality of life and survival outcome for patients with nasopharyngeal carcinoma receiving three-dimensional conformal radiotherapy vs. intensity-modulated radiotherapy-a longitudinal study. International Journal of Radiation Oncology, Biology, Physics, 72(2), 356-64. https://doi.org/10.1016/j.ijrobp.2007.12.054
Fang FM, et al. Quality of Life and Survival Outcome for Patients With Nasopharyngeal Carcinoma Receiving Three-dimensional Conformal Radiotherapy Vs. Intensity-modulated Radiotherapy-a Longitudinal Study. Int J Radiat Oncol Biol Phys. 2008 Oct 1;72(2):356-64. PubMed PMID: 18355980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quality of life and survival outcome for patients with nasopharyngeal carcinoma receiving three-dimensional conformal radiotherapy vs. intensity-modulated radiotherapy-a longitudinal study. AU - Fang,Fu-Min, AU - Chien,Chih-Yen, AU - Tsai,Wen-Ling, AU - Chen,Hui-Chun, AU - Hsu,Hsuan-Chih, AU - Lui,Chun-Chung, AU - Huang,Tai-Lin, AU - Huang,Hsuan-Ying, Y1 - 2008/03/20/ PY - 2007/09/13/received PY - 2007/12/24/revised PY - 2007/12/27/accepted PY - 2008/3/22/pubmed PY - 2008/10/22/medline PY - 2008/3/22/entrez SP - 356 EP - 64 JF - International journal of radiation oncology, biology, physics JO - Int J Radiat Oncol Biol Phys VL - 72 IS - 2 N2 - PURPOSE: To investigate the changes of quality of life (QoL) and survival outcomes for patients with nasopharyngeal carcinoma (NPC) treated by three-dimensional conformal radiotherapy (3D-CRT) vs. intensity-modulated radiotherapy (IMRT). METHODS AND MATERIALS: Two hundred and three newly diagnosed NPC patients, who were curatively treated by 3D-CRT (n = 93) or IMRT (n = 110) between March 2002 and July 2004, were analyzed. The distributions of clinical stage according to American Joint Committee on Cancer 1997 were I: 15 (7.4%), II: 78 (38.4%), III: 74 (36.5%), and IV: 36 (17.7%). QoL was longitudinally assessed by the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and the EORTC QLQ-H&N35 questionnaires at the five time points: before RT, during RT (36 Gy), and 3 months, 12 months, and 24 months after RT. RESULTS: The 3-year locoregional control, metastasis-free survival, and overall survival rates were 84.8%, 76.7%, and 81.7% for the 3D-CRT group, respectively, compared with 84.2%, 82.6%, and 85.4% for the IMRT group (p value > 0.05). A general trend of maximal deterioration in most QoL scales was observed during RT, followed by a gradual recovery thereafter. There was no significant difference in most scales between the two groups at each time point. The exception was that patients treated by IMRT had a both statistically and clinically significant improvement in global QoL, fatigue, taste/smell, dry mouth, and feeling ill at the time point of 3 months after RT. CONCLUSIONS: The potential advantage of IMRT over 3D-CRT in treating NPC patients might occur in QoL outcome during the recovery phase of acute toxicity. SN - 0360-3016 UR - https://www.unboundmedicine.com/medline/citation/18355980/Quality_of_life_and_survival_outcome_for_patients_with_nasopharyngeal_carcinoma_receiving_three_dimensional_conformal_radiotherapy_vs__intensity_modulated_radiotherapy_a_longitudinal_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0360-3016(08)00052-7 DB - PRIME DP - Unbound Medicine ER -