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Contraception with progestogens and progesterone during lactation.
J Steroid Biochem Mol Biol. 1991; 40(4-6):705-10.JS

Abstract

The growth and development of breastfed infants whose mothers used the contraceptive implants Norplant containing levonorgestrel and the injectable containing norethisterone enanthate were studied. Each group comprised of 120 women who initiated the use during the 5th to 7th week postpartum and were compared with a similar number of IUD using mothers. The breastfeeding performance did not differ between groups. The infants of the three groups performed similarly as regards their physical growth and health as well as the time of acquisition of the various milestones of psychomental development. A vaginal ring releasing 10 mg of the "natural" progesterone per 24 h was tested in breastfeeding mothers. The continuous use of the ring produced a serum level of progesterone around 4 ng/ml. This was effective in augmenting lactational infertility even through the later phases of breastfeeding when such an effect starts to wane off. The use of the ring proved to be acceptable and had no ill-effect on breastfeeding or infant growth or health. Using the natural progesterone as a contraceptive adds a new measure of safety, since the amount of the steroid secreted in the mother's milk will not be effectively absorbed from the infant's gut. These studies suggest the possibility of using two new methods for breastfeeding mothers; Norplant and the progesterone vaginal contraceptive ring. These can be initiated early postpartum, whenever this is considered needed.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Egypt.

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1835650

Citation

Shaaban, M M.. "Contraception With Progestogens and Progesterone During Lactation." The Journal of Steroid Biochemistry and Molecular Biology, vol. 40, no. 4-6, 1991, pp. 705-10.
Shaaban MM. Contraception with progestogens and progesterone during lactation. J Steroid Biochem Mol Biol. 1991;40(4-6):705-10.
Shaaban, M. M. (1991). Contraception with progestogens and progesterone during lactation. The Journal of Steroid Biochemistry and Molecular Biology, 40(4-6), 705-10.
Shaaban MM. Contraception With Progestogens and Progesterone During Lactation. J Steroid Biochem Mol Biol. 1991;40(4-6):705-10. PubMed PMID: 1835650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contraception with progestogens and progesterone during lactation. A1 - Shaaban,M M, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez KW - Africa KW - Arab Countries KW - Biodegradable Delivery Systems KW - Biology KW - Body Weight KW - Breast Feeding KW - Child Development KW - Clinical Research KW - Contraception KW - Contraception Continuation KW - Contraception Failure KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Effectiveness KW - Contraceptive Implants KW - Contraceptive Methods KW - Contraceptive Usage KW - Developing Countries KW - Egypt KW - Endocrine System KW - Estradiol KW - Estrogens KW - Family Planning KW - Growth KW - Health KW - Hormones KW - Human Volunteers KW - Infant Nutrition KW - Injectables KW - Iud KW - Iud, Copper Releasing KW - Levonorgestrel KW - Mediterranean Countries KW - Method Acceptability KW - Northern Africa KW - Nutrition KW - Nutrition Indexes KW - Organization And Administration KW - Ovulation KW - Physiology KW - Postpartum Women KW - Progestational Hormones KW - Progesterone KW - Program Accessibility KW - Program Evaluation KW - Programs KW - Puerperium KW - Reproduction KW - Research Methodology KW - Research Report KW - Supplementary Feeding KW - Ultrasonics KW - Use-effectiveness KW - Vaginal Rings KW - Weaning SP - 705 EP - 10 JF - The Journal of steroid biochemistry and molecular biology JO - J. Steroid Biochem. Mol. Biol. VL - 40 IS - 4-6 N2 - The growth and development of breastfed infants whose mothers used the contraceptive implants Norplant containing levonorgestrel and the injectable containing norethisterone enanthate were studied. Each group comprised of 120 women who initiated the use during the 5th to 7th week postpartum and were compared with a similar number of IUD using mothers. The breastfeeding performance did not differ between groups. The infants of the three groups performed similarly as regards their physical growth and health as well as the time of acquisition of the various milestones of psychomental development. A vaginal ring releasing 10 mg of the "natural" progesterone per 24 h was tested in breastfeeding mothers. The continuous use of the ring produced a serum level of progesterone around 4 ng/ml. This was effective in augmenting lactational infertility even through the later phases of breastfeeding when such an effect starts to wane off. The use of the ring proved to be acceptable and had no ill-effect on breastfeeding or infant growth or health. Using the natural progesterone as a contraceptive adds a new measure of safety, since the amount of the steroid secreted in the mother's milk will not be effectively absorbed from the infant's gut. These studies suggest the possibility of using two new methods for breastfeeding mothers; Norplant and the progesterone vaginal contraceptive ring. These can be initiated early postpartum, whenever this is considered needed. SN - 0960-0760 UR - https://www.unboundmedicine.com/medline/citation/1835650/Contraception_with_progestogens_and_progesterone_during_lactation_ DB - PRIME DP - Unbound Medicine ER -