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Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population: the MONICA/KORA cohort study.
Arterioscler Thromb Vasc Biol. 2008 Jun; 28(6):1186-92.AT

Abstract

OBJECTIVE

The purpose of this study was to assess whether increasing serum uric acid (UA) levels are related to cardiovascular disease (CVD) mortality, all-cause mortality, and incident (fatal and nonfatal) myocardial infarction (MI) in men from the general population taking into account C-reactive protein (CRP), a sensitive marker of systemic inflammation.

METHODS AND RESULTS

The study was based on 3604 men (45 to 74 years of age) who participated in 1 of the 3 MONICA Augsburg surveys between 1984 and 1995. All participants were prospectively followed within the framework of the Cooperative Health Research in the Region of Augsburg (KORA). Up to December 31, 2002, there occurred 809 total deaths, 359 CVD deaths, and 297 incident MIs. In a Cox model, comparing extreme quartiles of the UA distribution, the hazard ratio for CVD mortality was 1.44 (95% confidence interval [CI] 1.04 to 2.0), and for all-cause mortality it was 1.40 (95% CI 1.13 to 1.74) after adjustment for conventional cardiovascular risk factors, CRP, and diuretic intake. However, UA was not associated with incident MI after multivariable adjustment.

CONCLUSIONS

High UA levels were independently associated with CVD mortality as well as all-cause mortality but not with incident MI in middle-aged men from the general population.

Authors+Show Affiliations

Central Hospital of Augsburg, MONICA/KORA Myocardial Infarction Registry, Augsburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18356554

Citation

Meisinger, Christa, et al. "Uric Acid Levels Are Associated With All-cause and Cardiovascular Disease Mortality Independent of Systemic Inflammation in Men From the General Population: the MONICA/KORA Cohort Study." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 6, 2008, pp. 1186-92.
Meisinger C, Koenig W, Baumert J, et al. Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population: the MONICA/KORA cohort study. Arterioscler Thromb Vasc Biol. 2008;28(6):1186-92.
Meisinger, C., Koenig, W., Baumert, J., & Döring, A. (2008). Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population: the MONICA/KORA cohort study. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(6), 1186-92. https://doi.org/10.1161/ATVBAHA.107.160184
Meisinger C, et al. Uric Acid Levels Are Associated With All-cause and Cardiovascular Disease Mortality Independent of Systemic Inflammation in Men From the General Population: the MONICA/KORA Cohort Study. Arterioscler Thromb Vasc Biol. 2008;28(6):1186-92. PubMed PMID: 18356554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population: the MONICA/KORA cohort study. AU - Meisinger,Christa, AU - Koenig,Wolfgang, AU - Baumert,Jens, AU - Döring,Angela, Y1 - 2008/03/20/ PY - 2008/3/22/pubmed PY - 2008/6/11/medline PY - 2008/3/22/entrez SP - 1186 EP - 92 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler Thromb Vasc Biol VL - 28 IS - 6 N2 - OBJECTIVE: The purpose of this study was to assess whether increasing serum uric acid (UA) levels are related to cardiovascular disease (CVD) mortality, all-cause mortality, and incident (fatal and nonfatal) myocardial infarction (MI) in men from the general population taking into account C-reactive protein (CRP), a sensitive marker of systemic inflammation. METHODS AND RESULTS: The study was based on 3604 men (45 to 74 years of age) who participated in 1 of the 3 MONICA Augsburg surveys between 1984 and 1995. All participants were prospectively followed within the framework of the Cooperative Health Research in the Region of Augsburg (KORA). Up to December 31, 2002, there occurred 809 total deaths, 359 CVD deaths, and 297 incident MIs. In a Cox model, comparing extreme quartiles of the UA distribution, the hazard ratio for CVD mortality was 1.44 (95% confidence interval [CI] 1.04 to 2.0), and for all-cause mortality it was 1.40 (95% CI 1.13 to 1.74) after adjustment for conventional cardiovascular risk factors, CRP, and diuretic intake. However, UA was not associated with incident MI after multivariable adjustment. CONCLUSIONS: High UA levels were independently associated with CVD mortality as well as all-cause mortality but not with incident MI in middle-aged men from the general population. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/18356554/Uric_acid_levels_are_associated_with_all_cause_and_cardiovascular_disease_mortality_independent_of_systemic_inflammation_in_men_from_the_general_population:_the_MONICA/KORA_cohort_study_ L2 - https://www.ahajournals.org/doi/10.1161/ATVBAHA.107.160184?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -