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Treatment of high-risk older persons with lipid-lowering drug therapy.
Am J Ther 2008 Mar-Apr; 15(2):102-7AJ

Abstract

Randomized, double-blind, placebo-controlled studies and observational studies have demonstrated that statins reduce mortality and major cardiovascular events in high-risk persons with hypercholesterolemia. The aim of this study was to review the evidence for treating high-risk older persons with lipid-lowering drugs. A MEDLINE search of the English-language literature published from January 1, 1989, to June 2006 was conducted to review all studies in which lipid-lowering drug therapy was administered to high-risk older persons. The Heart Protection Study showed that statins reduced mortality and major cardiovascular events in high-risk persons, regardless of the initial level of serum lipids, age, or gender. The updated National Cholesterol Education Program (NCEP) III guidelines state that in very-high-risk patients, a serum low-density lipoprotein (LDL) cholesterol level of <70 mg/dL is a reasonable clinical strategy, regardless of age. When a high-risk person has hypertriglyceridemia or low serum high-density lipoprotein cholesterol, consideration can be given to combining a fibrate or nicotinic acid with an LDL cholesterol-lowering drug. For moderately-high-risk persons, the serum LDL cholesterol should be reduced to <100 mg/dL. When LDL cholesterol-lowering drug therapy is used for high-risk persons or moderately-high-risk persons, the serum LDL cholesterol should be reduced at least 30% to 40%. High-risk older persons should be treated with lipid-lowering drugs according to the NCEP III updated guidelines to reduce cardiovascular morbidity and mortality.

Authors+Show Affiliations

Department of Medicine, Divisions of Cardiology, Geriatrics, and Pulmonary/Critical Care, New York Medical College, Valhalla, NY 10595, USA. WSAronow@aol.com

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

18356628

Citation

Aronow, Wilbert S.. "Treatment of High-risk Older Persons With Lipid-lowering Drug Therapy." American Journal of Therapeutics, vol. 15, no. 2, 2008, pp. 102-7.
Aronow WS. Treatment of high-risk older persons with lipid-lowering drug therapy. Am J Ther. 2008;15(2):102-7.
Aronow, W. S. (2008). Treatment of high-risk older persons with lipid-lowering drug therapy. American Journal of Therapeutics, 15(2), pp. 102-7. doi:10.1097/MJT.0b013e31802b5aa4.
Aronow WS. Treatment of High-risk Older Persons With Lipid-lowering Drug Therapy. Am J Ther. 2008;15(2):102-7. PubMed PMID: 18356628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of high-risk older persons with lipid-lowering drug therapy. A1 - Aronow,Wilbert S, PY - 2008/3/22/pubmed PY - 2008/6/6/medline PY - 2008/3/22/entrez SP - 102 EP - 7 JF - American journal of therapeutics JO - Am J Ther VL - 15 IS - 2 N2 - Randomized, double-blind, placebo-controlled studies and observational studies have demonstrated that statins reduce mortality and major cardiovascular events in high-risk persons with hypercholesterolemia. The aim of this study was to review the evidence for treating high-risk older persons with lipid-lowering drugs. A MEDLINE search of the English-language literature published from January 1, 1989, to June 2006 was conducted to review all studies in which lipid-lowering drug therapy was administered to high-risk older persons. The Heart Protection Study showed that statins reduced mortality and major cardiovascular events in high-risk persons, regardless of the initial level of serum lipids, age, or gender. The updated National Cholesterol Education Program (NCEP) III guidelines state that in very-high-risk patients, a serum low-density lipoprotein (LDL) cholesterol level of <70 mg/dL is a reasonable clinical strategy, regardless of age. When a high-risk person has hypertriglyceridemia or low serum high-density lipoprotein cholesterol, consideration can be given to combining a fibrate or nicotinic acid with an LDL cholesterol-lowering drug. For moderately-high-risk persons, the serum LDL cholesterol should be reduced to <100 mg/dL. When LDL cholesterol-lowering drug therapy is used for high-risk persons or moderately-high-risk persons, the serum LDL cholesterol should be reduced at least 30% to 40%. High-risk older persons should be treated with lipid-lowering drugs according to the NCEP III updated guidelines to reduce cardiovascular morbidity and mortality. SN - 1536-3686 UR - https://www.unboundmedicine.com/medline/citation/18356628/Treatment_of_high_risk_older_persons_with_lipid_lowering_drug_therapy_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=18356628.ui DB - PRIME DP - Unbound Medicine ER -