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Intradialytic aerobic exercise training ameliorates symptoms of restless legs syndrome and improves functional capacity in patients on hemodialysis: a pilot study.
ASAIO J. 2008 Mar-Apr; 54(2):185-90.AJ

Abstract

We present the first study on the influence of exercise training on restless legs syndrome (RLS) in patients on hemodialysis (HD). Restless legs syndrome has been treated pharmacologically with satisfactory results; however, side effects and rebound phenomena have been reported. Intradialytic exercise training effectively counteracts uremia-induced catabolism; nevertheless, it remains unknown whether patients with RLS undergoing HD benefit from such programs. The aims of the current study were to evaluate the effect of 16-weeks aerobic exercise training in the severity of RLS and in the functional capacity and the quality of life of patients with RLS on HD. Fourteen patients on HD (four female, mean age 59 +/- 16 years) with untreated RLS were assigned, according to their will, to either the exercise group (Ex-group, n = 7), and participated in a 16-week supervised intradialytic aerobic exercise training, or to the control group (Con-group, n = 7), and continued usual activities. Primary aim was to compare the International RLS (IRLS) study group rating scale, functional ability, and quality of life in baseline and the end of the 16 weeks. Exercise training reduced IRLS score by 42% (p = 0.02). Furthermore, it significantly improved indices of functional ability (p = 0.02), exercise capacity (p = 0.01), quality of life (p = 0.03), and sleep quality (p = 0.01). In the Con-group no changes were observed. In conclusion, aerobic exercise training is safe and efficacious in reducing RLS symptoms and improving quality of life in patients with RLS on HD.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Sakkas GK
Department of Nephrology, School of Medicine, University of Thessaly, Greece.
Hadjigeorgiou GM
No affiliation info available
Karatzaferi C
No affiliation info available
Maridaki MD
No affiliation info available
Giannaki CD
No affiliation info available
Mertens PR
No affiliation info available
Rountas C
No affiliation info available
Vlychou M
No affiliation info available
Liakopoulos V
No affiliation info available
Stefanidis I
No affiliation info available

MeSH

AgedExerciseExercise TherapyFemaleHumansKidney Failure, ChronicMaleMiddle AgedPilot ProjectsQuality of LifeRenal DialysisRestless Legs SyndromeTreatment Outcome

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18356653

Citation

Sakkas, Giorgos K., et al. "Intradialytic Aerobic Exercise Training Ameliorates Symptoms of Restless Legs Syndrome and Improves Functional Capacity in Patients On Hemodialysis: a Pilot Study." ASAIO Journal (American Society for Artificial Internal Organs : 1992), vol. 54, no. 2, 2008, pp. 185-90.
Sakkas GK, Hadjigeorgiou GM, Karatzaferi C, et al. Intradialytic aerobic exercise training ameliorates symptoms of restless legs syndrome and improves functional capacity in patients on hemodialysis: a pilot study. ASAIO J. 2008;54(2):185-90.
Sakkas, G. K., Hadjigeorgiou, G. M., Karatzaferi, C., Maridaki, M. D., Giannaki, C. D., Mertens, P. R., Rountas, C., Vlychou, M., Liakopoulos, V., & Stefanidis, I. (2008). Intradialytic aerobic exercise training ameliorates symptoms of restless legs syndrome and improves functional capacity in patients on hemodialysis: a pilot study. ASAIO Journal (American Society for Artificial Internal Organs : 1992), 54(2), 185-90. https://doi.org/10.1097/MAT.0b013e3181641b07
Sakkas GK, et al. Intradialytic Aerobic Exercise Training Ameliorates Symptoms of Restless Legs Syndrome and Improves Functional Capacity in Patients On Hemodialysis: a Pilot Study. ASAIO J. 2008 Mar-Apr;54(2):185-90. PubMed PMID: 18356653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intradialytic aerobic exercise training ameliorates symptoms of restless legs syndrome and improves functional capacity in patients on hemodialysis: a pilot study. AU - Sakkas,Giorgos K, AU - Hadjigeorgiou,Georgios M, AU - Karatzaferi,Christina, AU - Maridaki,Maria D, AU - Giannaki,Christoforos D, AU - Mertens,Peter R, AU - Rountas,Christos, AU - Vlychou,Marianna, AU - Liakopoulos,Vassilios, AU - Stefanidis,Ioannis, PY - 2008/3/22/pubmed PY - 2008/5/14/medline PY - 2008/3/22/entrez SP - 185 EP - 90 JF - ASAIO journal (American Society for Artificial Internal Organs : 1992) JO - ASAIO J VL - 54 IS - 2 N2 - We present the first study on the influence of exercise training on restless legs syndrome (RLS) in patients on hemodialysis (HD). Restless legs syndrome has been treated pharmacologically with satisfactory results; however, side effects and rebound phenomena have been reported. Intradialytic exercise training effectively counteracts uremia-induced catabolism; nevertheless, it remains unknown whether patients with RLS undergoing HD benefit from such programs. The aims of the current study were to evaluate the effect of 16-weeks aerobic exercise training in the severity of RLS and in the functional capacity and the quality of life of patients with RLS on HD. Fourteen patients on HD (four female, mean age 59 +/- 16 years) with untreated RLS were assigned, according to their will, to either the exercise group (Ex-group, n = 7), and participated in a 16-week supervised intradialytic aerobic exercise training, or to the control group (Con-group, n = 7), and continued usual activities. Primary aim was to compare the International RLS (IRLS) study group rating scale, functional ability, and quality of life in baseline and the end of the 16 weeks. Exercise training reduced IRLS score by 42% (p = 0.02). Furthermore, it significantly improved indices of functional ability (p = 0.02), exercise capacity (p = 0.01), quality of life (p = 0.03), and sleep quality (p = 0.01). In the Con-group no changes were observed. In conclusion, aerobic exercise training is safe and efficacious in reducing RLS symptoms and improving quality of life in patients with RLS on HD. SN - 1538-943X UR - https://www.unboundmedicine.com/medline/citation/18356653/Intradialytic_aerobic_exercise_training_ameliorates_symptoms_of_restless_legs_syndrome_and_improves_functional_capacity_in_patients_on_hemodialysis:_a_pilot_study_ DB - PRIME DP - Unbound Medicine ER -