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The effects of aspirin and nonselective beta blockade on the acute prothrombotic response to psychosocial stress in apparently healthy subjects.
J Cardiovasc Pharmacol. 2008 Mar; 51(3):231-8.JC

Abstract

We hypothesized that the 2 cardiovascular drugs aspirin and propranolol attenuate the prothrombotic response to acute psychosocial stress relative to placebo medication. We randomized 56 healthy subjects, double-blind, to 5-day treatment with an oral dose of either 100 mg of aspirin plus 80 mg of propranolol combined, single aspirin, single propranolol, or placebo medication. Thereafter, subjects underwent a 13-minute psychosocial stressor. Plasma levels of von Willebrand factor antigen (VWF:Ag), fibrinogen, coagulation factor VII (FVII:C) and XII (FXII:C) activity, and D-dimer were determined in blood samples collected immediately pre- and post-stress and 45 minutes post-stress. The stress-induced changes in prothrombotic measures were adjusted for gender, age, body mass index, mean arterial blood pressure, smoking status, and sleep quality. There was an increase in VWF:Ag levels from immediately pre-stress to 45 minutes post-stress in the placebo group relative to the 3 subject groups with verum medication (P's </= 0.019; relative increase in VWF:Ag between 17% and 21%); however, the VWF:Ag response to stress was not significantly different between the three groups with verum medication. The stress responses in fibrinogen, FVII:C, FXII:C, and D-dimer were similar in all 4 medication groups. The combination of aspirin with propranolol, single aspirin, and single propranolol all attenuated the acute response in plasma VWF:Ag levels to psychosocial stress. This suggests that these cardiovascular drugs might exert limited protection from the development of stress-triggered coronary thrombosis.

Authors+Show Affiliations

Department of General Internal Medicine, University Hospital Berne, Switzerland. roland.vonkaenel@insel.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18356686

Citation

von Känel, Roland, et al. "The Effects of Aspirin and Nonselective Beta Blockade On the Acute Prothrombotic Response to Psychosocial Stress in Apparently Healthy Subjects." Journal of Cardiovascular Pharmacology, vol. 51, no. 3, 2008, pp. 231-8.
von Känel R, Kudielka BM, Helfricht S, et al. The effects of aspirin and nonselective beta blockade on the acute prothrombotic response to psychosocial stress in apparently healthy subjects. J Cardiovasc Pharmacol. 2008;51(3):231-8.
von Känel, R., Kudielka, B. M., Helfricht, S., Metzenthin, P., Preckel, D., Haeberli, A., Cung, T., & Fischer, J. E. (2008). The effects of aspirin and nonselective beta blockade on the acute prothrombotic response to psychosocial stress in apparently healthy subjects. Journal of Cardiovascular Pharmacology, 51(3), 231-8. https://doi.org/10.1097/FJC.0b013e318161ea63
von Känel R, et al. The Effects of Aspirin and Nonselective Beta Blockade On the Acute Prothrombotic Response to Psychosocial Stress in Apparently Healthy Subjects. J Cardiovasc Pharmacol. 2008;51(3):231-8. PubMed PMID: 18356686.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of aspirin and nonselective beta blockade on the acute prothrombotic response to psychosocial stress in apparently healthy subjects. AU - von Känel,Roland, AU - Kudielka,Brigitte M, AU - Helfricht,Susanne, AU - Metzenthin,Petra, AU - Preckel,Daniel, AU - Haeberli,André, AU - Cung,Trinh, AU - Fischer,Joachim E, PY - 2008/3/22/pubmed PY - 2008/7/23/medline PY - 2008/3/22/entrez SP - 231 EP - 8 JF - Journal of cardiovascular pharmacology JO - J Cardiovasc Pharmacol VL - 51 IS - 3 N2 - We hypothesized that the 2 cardiovascular drugs aspirin and propranolol attenuate the prothrombotic response to acute psychosocial stress relative to placebo medication. We randomized 56 healthy subjects, double-blind, to 5-day treatment with an oral dose of either 100 mg of aspirin plus 80 mg of propranolol combined, single aspirin, single propranolol, or placebo medication. Thereafter, subjects underwent a 13-minute psychosocial stressor. Plasma levels of von Willebrand factor antigen (VWF:Ag), fibrinogen, coagulation factor VII (FVII:C) and XII (FXII:C) activity, and D-dimer were determined in blood samples collected immediately pre- and post-stress and 45 minutes post-stress. The stress-induced changes in prothrombotic measures were adjusted for gender, age, body mass index, mean arterial blood pressure, smoking status, and sleep quality. There was an increase in VWF:Ag levels from immediately pre-stress to 45 minutes post-stress in the placebo group relative to the 3 subject groups with verum medication (P's </= 0.019; relative increase in VWF:Ag between 17% and 21%); however, the VWF:Ag response to stress was not significantly different between the three groups with verum medication. The stress responses in fibrinogen, FVII:C, FXII:C, and D-dimer were similar in all 4 medication groups. The combination of aspirin with propranolol, single aspirin, and single propranolol all attenuated the acute response in plasma VWF:Ag levels to psychosocial stress. This suggests that these cardiovascular drugs might exert limited protection from the development of stress-triggered coronary thrombosis. SN - 0160-2446 UR - https://www.unboundmedicine.com/medline/citation/18356686/The_effects_of_aspirin_and_nonselective_beta_blockade_on_the_acute_prothrombotic_response_to_psychosocial_stress_in_apparently_healthy_subjects_ L2 - https://doi.org/10.1097/FJC.0b013e318161ea63 DB - PRIME DP - Unbound Medicine ER -