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Anti-tumor actions of major component 3'-O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation.
Cancer Lett 2008; 265(1):84-97CL

Abstract

We recently demonstrated that two chalcones isolated from Angelica keiskei roots have anti-tumor and anti-metastatic activities through the inhibition of tumor-induced angiogenesis, but the anti-tumor substances of Angelica japonica roots are unknown. We attempted to clarify the anti-tumor action and its mechanisms of a major component 3'-O-acetylhamaudol isolated from A. japonica roots. We first examined the effects of 3'-O-acetylhamaudol on tumor growth in colon 26-bearing mice. Furthermore, we examined the effects of 3'-O-acetylhamaudol on angiogenic factors (vascular endothelial growth factor receptor-2 (VEGFR-2) phosphorylation in human umbilical vein endothelial cells (HUVECs), and vascular endothelial growth factor (VEGF) production and hypoxia-inducible factor (HIF)-1alpha expression in tumors). 3'-O-Acetylhamaudol (25 and 50 mg/kg, twice daily) inhibited the tumor growth in colon 26-bearing mice. Although 3'-O-acetylhamudol had no effect on the VEGF production and HIF-1alpha in colon 26 cells, it (10 microM) inhibited the VEGF-induced angiogenesis and VEGF-induced VEGFR-2 phosphorylation in HUVECs. 3'-O-Acetylhamaudol has anti-tumor effects mediated through dual mechanisms, i.e., anti-angiogenic actions and the modulation of the immune system in the spleen and small intestine in tumor-bearing mice.

Authors+Show Affiliations

Division of Biochemical Pharmacology, Department of Basic Medical Research Graduate School of Medicine, Ehime University, Shitsukawa, Toon City, Ehime 791-0295, Japan. yokim@m.ehime-u.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18358599

Citation

Kimura, Yoshiyuki, et al. "Anti-tumor Actions of Major Component 3'-O-acetylhamaudol of Angelica Japonica Roots Through Dual Actions, Anti-angiogenesis and Intestinal Intraepithelial Lymphocyte Activation." Cancer Letters, vol. 265, no. 1, 2008, pp. 84-97.
Kimura Y, Sumiyoshi M, Baba K. Anti-tumor actions of major component 3'-O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation. Cancer Lett. 2008;265(1):84-97.
Kimura, Y., Sumiyoshi, M., & Baba, K. (2008). Anti-tumor actions of major component 3'-O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation. Cancer Letters, 265(1), pp. 84-97. doi:10.1016/j.canlet.2008.02.009.
Kimura Y, Sumiyoshi M, Baba K. Anti-tumor Actions of Major Component 3'-O-acetylhamaudol of Angelica Japonica Roots Through Dual Actions, Anti-angiogenesis and Intestinal Intraepithelial Lymphocyte Activation. Cancer Lett. 2008 Jun 28;265(1):84-97. PubMed PMID: 18358599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-tumor actions of major component 3'-O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation. AU - Kimura,Yoshiyuki, AU - Sumiyoshi,Maho, AU - Baba,Kimiye, Y1 - 2008/03/20/ PY - 2007/10/30/received PY - 2008/01/30/revised PY - 2008/02/03/accepted PY - 2008/3/25/pubmed PY - 2008/9/3/medline PY - 2008/3/25/entrez SP - 84 EP - 97 JF - Cancer letters JO - Cancer Lett. VL - 265 IS - 1 N2 - We recently demonstrated that two chalcones isolated from Angelica keiskei roots have anti-tumor and anti-metastatic activities through the inhibition of tumor-induced angiogenesis, but the anti-tumor substances of Angelica japonica roots are unknown. We attempted to clarify the anti-tumor action and its mechanisms of a major component 3'-O-acetylhamaudol isolated from A. japonica roots. We first examined the effects of 3'-O-acetylhamaudol on tumor growth in colon 26-bearing mice. Furthermore, we examined the effects of 3'-O-acetylhamaudol on angiogenic factors (vascular endothelial growth factor receptor-2 (VEGFR-2) phosphorylation in human umbilical vein endothelial cells (HUVECs), and vascular endothelial growth factor (VEGF) production and hypoxia-inducible factor (HIF)-1alpha expression in tumors). 3'-O-Acetylhamaudol (25 and 50 mg/kg, twice daily) inhibited the tumor growth in colon 26-bearing mice. Although 3'-O-acetylhamudol had no effect on the VEGF production and HIF-1alpha in colon 26 cells, it (10 microM) inhibited the VEGF-induced angiogenesis and VEGF-induced VEGFR-2 phosphorylation in HUVECs. 3'-O-Acetylhamaudol has anti-tumor effects mediated through dual mechanisms, i.e., anti-angiogenic actions and the modulation of the immune system in the spleen and small intestine in tumor-bearing mice. SN - 0304-3835 UR - https://www.unboundmedicine.com/medline/citation/18358599/Anti_tumor_actions_of_major_component_3'_O_acetylhamaudol_of_Angelica_japonica_roots_through_dual_actions_anti_angiogenesis_and_intestinal_intraepithelial_lymphocyte_activation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3835(08)00088-8 DB - PRIME DP - Unbound Medicine ER -