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Clinical and virological features of an aseptic meningitis outbreak in North-Eastern France, 2005.
J Clin Virol. 2008 Jun; 42(2):225-8.JC

Abstract

BACKGROUND

Enteroviruses (EVs) are considered as a major viral etiological cause of aseptic meningitis in children.

OBJECTIVES

We assessed the clinical and virological features of an aseptic meningitis outbreak in North-East of France, 2005.

STUDY DESIGN

Classical bacteriological analysis, Herpesviridae and EV PCR assays had been prospectively performed on cerebrospinal fluid (CSF) samples taken from 80 children hospitalized for aseptic meningitis. For each EV strain identified as etiological agent, a phylogenetic comparison of partial EV VP1 capsid protein coding gene was performed.

RESULTS

The children older than 12 months (n=75) presented a typical aseptic meningitis syndrome, whereas the children aged less than 1 year (n=5) demonstrated only fever and hypotonia. Among the 80 studied children, EV was identified as the etiological cause of aseptic meningitis in 73 (91%) cases. Echovirus 30 (E30) was the most common isolated serotype (84% of 51 EV strains). VP1 phylogenetic analysis revealed that E30 strains were genetically closer to those isolated during 2000 aseptic meningitis outbreak comparatively to those identified during 2003 and 2006 non-epidemic years. Moreover, the genetic study demonstrated the co-circulation of four distinct lineages without any difference in temporal distribution or clinical features during the 2005 outbreak.

CONCLUSIONS

The present report demonstrates the co-circulation of distinct E30 lineages during the same aseptic meningitis outbreak season. This E30 genetic diversity may be a prerequisite for the emergence of new strains potentially responsible for further aseptic meningitis outbreaks.

Authors+Show Affiliations

Laboratoire de virologie médicale et moléculaire, Centre Hospitalier Universitaire de Reims, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18358773

Citation

Brunel, Delphine, et al. "Clinical and Virological Features of an Aseptic Meningitis Outbreak in North-Eastern France, 2005." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 42, no. 2, 2008, pp. 225-8.
Brunel D, Lévêque N, Jacques J, et al. Clinical and virological features of an aseptic meningitis outbreak in North-Eastern France, 2005. J Clin Virol. 2008;42(2):225-8.
Brunel, D., Lévêque, N., Jacques, J., Renois, F., Motte, J., & Andréoletti, L. (2008). Clinical and virological features of an aseptic meningitis outbreak in North-Eastern France, 2005. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 42(2), 225-8. https://doi.org/10.1016/j.jcv.2008.02.008
Brunel D, et al. Clinical and Virological Features of an Aseptic Meningitis Outbreak in North-Eastern France, 2005. J Clin Virol. 2008;42(2):225-8. PubMed PMID: 18358773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and virological features of an aseptic meningitis outbreak in North-Eastern France, 2005. AU - Brunel,Delphine, AU - Lévêque,Nicolas, AU - Jacques,Jérôme, AU - Renois,Fanny, AU - Motte,Jacques, AU - Andréoletti,Laurent, Y1 - 2008/03/20/ PY - 2008/02/05/received PY - 2008/02/08/accepted PY - 2008/3/25/pubmed PY - 2008/8/13/medline PY - 2008/3/25/entrez SP - 225 EP - 8 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 42 IS - 2 N2 - BACKGROUND: Enteroviruses (EVs) are considered as a major viral etiological cause of aseptic meningitis in children. OBJECTIVES: We assessed the clinical and virological features of an aseptic meningitis outbreak in North-East of France, 2005. STUDY DESIGN: Classical bacteriological analysis, Herpesviridae and EV PCR assays had been prospectively performed on cerebrospinal fluid (CSF) samples taken from 80 children hospitalized for aseptic meningitis. For each EV strain identified as etiological agent, a phylogenetic comparison of partial EV VP1 capsid protein coding gene was performed. RESULTS: The children older than 12 months (n=75) presented a typical aseptic meningitis syndrome, whereas the children aged less than 1 year (n=5) demonstrated only fever and hypotonia. Among the 80 studied children, EV was identified as the etiological cause of aseptic meningitis in 73 (91%) cases. Echovirus 30 (E30) was the most common isolated serotype (84% of 51 EV strains). VP1 phylogenetic analysis revealed that E30 strains were genetically closer to those isolated during 2000 aseptic meningitis outbreak comparatively to those identified during 2003 and 2006 non-epidemic years. Moreover, the genetic study demonstrated the co-circulation of four distinct lineages without any difference in temporal distribution or clinical features during the 2005 outbreak. CONCLUSIONS: The present report demonstrates the co-circulation of distinct E30 lineages during the same aseptic meningitis outbreak season. This E30 genetic diversity may be a prerequisite for the emergence of new strains potentially responsible for further aseptic meningitis outbreaks. SN - 1386-6532 UR - https://www.unboundmedicine.com/medline/citation/18358773/Clinical_and_virological_features_of_an_aseptic_meningitis_outbreak_in_North_Eastern_France_2005_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(08)00067-X DB - PRIME DP - Unbound Medicine ER -